Potassium in PDB 7fha: Crystal Structure of the Atp Sulfurylase Domain of Human PAPSS2 in Complex with Aps

All present enzymatic activity of Crystal Structure of the Atp Sulfurylase Domain of Human PAPSS2 in Complex with Aps:
2.7.1.25; 2.7.7.4;

The structure of Crystal Structure of the Atp Sulfurylase Domain of Human PAPSS2 in Complex with Aps, PDB code: 7fha was solved by P.Zhang, L.Zhang, L.Zhang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.18 / 2.00
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	62.111, 131.105, 135.94, 90, 90, 90
R / Rfree (%)	15.2 / 18.3

The binding sites of Potassium atom in the Crystal Structure of the Atp Sulfurylase Domain of Human PAPSS2 in Complex with Aps (pdb code 7fha). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Crystal Structure of the Atp Sulfurylase Domain of Human PAPSS2 in Complex with Aps, PDB code: 7fha:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the Crystal Structure of the Atp Sulfurylase Domain of Human PAPSS2 in Complex with Aps


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of the Atp Sulfurylase Domain of Human PAPSS2 in Complex with Aps within 5.0Å range: probe atom residue distance (Å) B Occ A:K1003 b:70.5 occ:1.00 OD2 A:ASP364 3.0 42.7 1.0 O A:HOH1432 3.0 35.3 1.0 N A:ALA304 3.1 20.2 1.0 N A:ASP364 3.1 24.1 1.0 CG A:ASP364 3.4 35.2 1.0 CA A:SER303 3.5 23.7 1.0 CA A:GLY363 3.6 28.2 1.0 CB A:ASP364 3.7 32.5 1.0 C A:SER303 3.8 20.6 1.0 C A:GLY363 3.9 30.6 1.0 CB A:ALA304 4.0 25.8 1.0 CA A:ASP364 4.0 24.6 1.0 CB A:SER303 4.1 26.7 1.0 CA A:ALA304 4.1 23.9 1.0 O A:HOH1368 4.1 27.9 1.0 OD1 A:ASP364 4.2 39.4 1.0 O A:VAL302 4.4 23.0 1.0 O A:HOH1379 4.6 41.4 1.0 N A:SER303 4.7 21.2 1.0 N A:GLY363 4.9 25.9 1.0 O A:SER303 4.9 21.9 1.0 O A:SER362 4.9 28.1 1.0 C A:VAL302 5.0 19.0 1.0

Potassium binding site 2 out of 2 in the Crystal Structure of the Atp Sulfurylase Domain of Human PAPSS2 in Complex with Aps


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of the Atp Sulfurylase Domain of Human PAPSS2 in Complex with Aps within 5.0Å range: probe atom residue distance (Å) B Occ B:K1003 b:79.3 occ:1.00 O B:HOH1535 2.6 36.8 1.0 OD2 B:ASP364 3.1 47.7 1.0 N B:ASP364 3.1 23.6 1.0 N B:ALA304 3.2 22.1 1.0 CG B:ASP364 3.4 41.7 1.0 CA B:SER303 3.6 24.2 1.0 CB B:ASP364 3.6 29.9 1.0 CA B:GLY363 3.8 25.9 1.0 C B:SER303 3.9 20.2 1.0 C B:GLY363 4.0 25.5 1.0 CA B:ASP364 4.0 26.1 1.0 CB B:SER303 4.0 26.1 1.0 CB B:ALA304 4.1 26.5 1.0 OD1 B:ASP364 4.2 38.9 1.0 CA B:ALA304 4.2 24.9 1.0 O B:HOH1423 4.3 34.2 1.0 O B:HOH1438 4.5 46.1 1.0 O B:VAL302 4.5 21.0 1.0 N B:SER303 4.7 24.6 1.0

P.Zhang, L.Zhang, Z.Hou, H.Liu, H.Gao, L.Zhang. Structural Basis For the Substrate Recognition Mechanism of Atp-Sulfurylase Domain of Human Paps Synthase 2 Biochem.Biophys.Res.Commun. V. 586 2022.
ISSN: ESSN 1090-2104
DOI: 10.1016/J.BBRC.2021.11.062