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Potassium in PDB 6p1m: Binary Complex of Human Dna Polymerase Mu with 1-Nt Gapped Substrate Containing Template 8OG

Enzymatic activity of Binary Complex of Human Dna Polymerase Mu with 1-Nt Gapped Substrate Containing Template 8OG

All present enzymatic activity of Binary Complex of Human Dna Polymerase Mu with 1-Nt Gapped Substrate Containing Template 8OG:
2.7.7.7;

Protein crystallography data

The structure of Binary Complex of Human Dna Polymerase Mu with 1-Nt Gapped Substrate Containing Template 8OG, PDB code: 6p1m was solved by A.M.Kaminski, L.C.Pedersen, K.Bebenek, K.K.Chiruvella, D.A.Ramsden, T.A.Kunkel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 26.13 / 1.65
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 59.929, 68.263, 110.413, 90.00, 90.00, 90.00
R / Rfree (%) 16.6 / 19

Other elements in 6p1m:

The structure of Binary Complex of Human Dna Polymerase Mu with 1-Nt Gapped Substrate Containing Template 8OG also contains other interesting chemical elements:

Bromine (Br) 2 atoms
Chlorine (Cl) 2 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the Binary Complex of Human Dna Polymerase Mu with 1-Nt Gapped Substrate Containing Template 8OG (pdb code 6p1m). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Binary Complex of Human Dna Polymerase Mu with 1-Nt Gapped Substrate Containing Template 8OG, PDB code: 6p1m:

Potassium binding site 1 out of 1 in 6p1m

Go back to Potassium Binding Sites List in 6p1m
Potassium binding site 1 out of 1 in the Binary Complex of Human Dna Polymerase Mu with 1-Nt Gapped Substrate Containing Template 8OG


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Binary Complex of Human Dna Polymerase Mu with 1-Nt Gapped Substrate Containing Template 8OG within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K502

b:18.3
occ:0.86
 O A:VAL246 2.6 19.8 1.0
O A:THR241 2.7 20.1 1.0
O A:ILE243 2.7 20.2 1.0
OP1 P:DT3 2.7 17.2 1.0
O P:HOH114 2.8 33.4 0.8
O A:HOH803 3.1 36.0 1.0
O P:HOH113 3.1 36.2 0.8
C A:ILE243 3.6 20.0 1.0
C A:VAL246 3.7 18.4 1.0
C A:THR241 3.7 20.5 1.0
P P:DT3 3.8 17.7 1.0
OP2 P:DT3 3.9 16.1 1.0
N A:VAL246 4.0 17.8 1.0
C A:GLN242 4.2 23.4 1.0
N A:ILE243 4.3 19.4 1.0
N A:PHE244 4.3 19.3 1.0
CA A:PHE244 4.3 21.6 1.0
CA A:VAL246 4.3 18.0 1.0
CA A:THR241 4.4 19.4 1.0
N A:GLY245 4.4 18.5 1.0
O A:HOH782 4.4 36.3 0.8
O A:GLN242 4.4 27.3 1.0
CA A:ILE243 4.6 20.0 1.0
N A:GLN242 4.6 20.3 1.0
O A:HOH870 4.7 42.0 1.0
CA A:GLN242 4.7 23.0 1.0
N A:GLY247 4.7 17.5 1.0
CB A:VAL246 4.8 17.8 1.0
C A:PHE244 4.8 20.8 1.0
O3' P:DG2 4.8 17.6 1.0
O5' P:DT3 4.9 17.4 1.0
CB A:THR241 5.0 20.7 1.0

Reference:

A.M.Kaminski, K.K.Chiruvella, D.A.Ramsden, T.A.Kunkel, K.Bebenek, L.C.Pedersen. Unexpected Behavior of Dna Polymerase Mu Opposite Template 8-Oxo-7,8-Dihydro-2'-Guanosine. Nucleic Acids Res. V. 47 9410 2019.
ISSN: ESSN 1362-4962
PubMed: 31435651
DOI: 10.1093/NAR/GKZ680
Page generated: Mon Aug 12 17:06:01 2024

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