Potassium in PDB 6p0y: Cryptosporidium Parvum Pyruvate Kinase in Complex with Adp

All present enzymatic activity of Cryptosporidium Parvum Pyruvate Kinase in Complex with Adp:
2.7.1.40;

The structure of Cryptosporidium Parvum Pyruvate Kinase in Complex with Adp, PDB code: 6p0y was solved by N.Schormann, D.Chattopadhyay, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.03 / 2.60
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	133.465, 105.305, 83.453, 90.00, 90.00, 90.00
R / Rfree (%)	21.7 / 26.8

The structure of Cryptosporidium Parvum Pyruvate Kinase in Complex with Adp also contains other interesting chemical elements:

Magnesium	(Mg)	2 atoms
Chlorine	(Cl)	2 atoms

The binding sites of Potassium atom in the Cryptosporidium Parvum Pyruvate Kinase in Complex with Adp (pdb code 6p0y). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Cryptosporidium Parvum Pyruvate Kinase in Complex with Adp, PDB code: 6p0y:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the Cryptosporidium Parvum Pyruvate Kinase in Complex with Adp


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Cryptosporidium Parvum Pyruvate Kinase in Complex with Adp within 5.0Å range: probe atom residue distance (Å) B Occ A:K603 b:44.9 occ:1.00 OG A:SER78 2.8 36.6 1.0 O A:THR110 2.8 35.5 1.0 OD1 A:ASN76 2.8 34.6 1.0 OD1 A:ASP109 2.9 31.5 1.0 OG A:SER236 3.7 32.7 1.0 C A:THR110 3.7 36.1 1.0 CG A:ASN76 3.8 34.6 1.0 CG A:ASP109 3.8 31.2 1.0 O A:ASP109 3.9 30.1 1.0 CB A:SER78 3.9 37.5 1.0 NZ A:LYS270 4.0 32.0 1.0 CA A:LYS111 4.2 41.4 1.0 C A:ASP109 4.2 31.0 1.0 ND2 A:ASN76 4.3 34.5 1.0 N A:LYS111 4.3 38.6 1.0 OE1 A:GLU114 4.3 54.3 1.0 O A:LYS111 4.3 43.0 1.0 N A:SER78 4.5 36.6 1.0 CB A:ASP109 4.5 31.0 1.0 N A:THR110 4.6 32.5 1.0 OD2 A:ASP109 4.6 31.1 1.0 NH2 A:ARG74 4.7 34.3 1.0 C A:LYS111 4.7 42.0 1.0 CB A:SER236 4.8 33.1 1.0 CA A:SER78 4.8 38.0 1.0 CA A:THR110 4.8 34.2 1.0 CA A:ASP109 5.0 30.9 1.0 CB A:ASN76 5.0 34.7 1.0

Potassium binding site 2 out of 2 in the Cryptosporidium Parvum Pyruvate Kinase in Complex with Adp


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Cryptosporidium Parvum Pyruvate Kinase in Complex with Adp within 5.0Å range: probe atom residue distance (Å) B Occ B:K603 b:40.2 occ:1.00 O B:THR110 2.8 37.4 1.0 OD1 B:ASN76 2.8 29.6 1.0 O B:HOH780 2.8 12.1 1.0 OG B:SER78 2.8 34.6 1.0 OD1 B:ASP109 2.9 32.3 1.0 OG B:SER236 3.7 30.6 1.0 C B:THR110 3.7 37.1 1.0 O B:HOH778 3.7 31.0 1.0 CG B:ASN76 3.8 30.1 1.0 CG B:ASP109 3.8 31.8 1.0 O B:ASP109 3.9 33.6 1.0 CB B:SER78 4.0 34.6 1.0 NZ B:LYS270 4.0 29.2 1.0 CA B:LYS111 4.2 39.6 1.0 C B:ASP109 4.2 33.3 1.0 N B:LYS111 4.2 38.6 1.0 ND2 B:ASN76 4.2 30.4 1.0 O B:LYS111 4.3 39.5 1.0 N B:SER78 4.4 33.9 1.0 CB B:ASP109 4.5 31.8 1.0 N B:THR110 4.5 35.1 1.0 OE1 B:GLU114 4.6 49.3 1.0 OD2 B:ASP109 4.6 31.3 1.0 NH2 B:ARG74 4.6 30.2 1.0 C B:LYS111 4.6 39.4 1.0 CA B:THR110 4.7 36.6 1.0 CB B:SER236 4.8 30.8 1.0 CA B:SER78 4.8 34.6 1.0 CA B:ASP109 4.9 31.7 1.0 CB B:ASN76 4.9 30.1 1.0 N B:PHE77 4.9 31.9 1.0

N.Schormann, K.L.Hayden, P.Lee, S.Banerjee, D.Chattopadhyay. An Overview of Structure, Function, and Regulation of Pyruvate Kinases. Protein Sci. V. 28 1771 2019.
ISSN: ESSN 1469-896X
PubMed: 31342570
DOI: 10.1002/PRO.3691