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Potassium in PDB 6of8: Structure of THR354ASN, GLU355GLN, THR412ASN, ILE414MET, ILE464HIS, and PHE467MET Mutant Human Camkii-Alpha Hub Domain

Enzymatic activity of Structure of THR354ASN, GLU355GLN, THR412ASN, ILE414MET, ILE464HIS, and PHE467MET Mutant Human Camkii-Alpha Hub Domain

All present enzymatic activity of Structure of THR354ASN, GLU355GLN, THR412ASN, ILE414MET, ILE464HIS, and PHE467MET Mutant Human Camkii-Alpha Hub Domain:
2.7.11.17;

Protein crystallography data

The structure of Structure of THR354ASN, GLU355GLN, THR412ASN, ILE414MET, ILE464HIS, and PHE467MET Mutant Human Camkii-Alpha Hub Domain, PDB code: 6of8 was solved by E.D.Mcspadden, C.C.Chi, C.L.Gee, J.Kuriyan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.51 / 2.10
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 162.985, 121.343, 56.239, 90.00, 108.15, 90.00
R / Rfree (%) 22.2 / 25.8

Potassium Binding Sites:

The binding sites of Potassium atom in the Structure of THR354ASN, GLU355GLN, THR412ASN, ILE414MET, ILE464HIS, and PHE467MET Mutant Human Camkii-Alpha Hub Domain (pdb code 6of8). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 5 binding sites of Potassium where determined in the Structure of THR354ASN, GLU355GLN, THR412ASN, ILE414MET, ILE464HIS, and PHE467MET Mutant Human Camkii-Alpha Hub Domain, PDB code: 6of8:
Jump to Potassium binding site number: 1; 2; 3; 4; 5;

Potassium binding site 1 out of 5 in 6of8

Go back to Potassium Binding Sites List in 6of8
Potassium binding site 1 out of 5 in the Structure of THR354ASN, GLU355GLN, THR412ASN, ILE414MET, ILE464HIS, and PHE467MET Mutant Human Camkii-Alpha Hub Domain


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Structure of THR354ASN, GLU355GLN, THR412ASN, ILE414MET, ILE464HIS, and PHE467MET Mutant Human Camkii-Alpha Hub Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
F:K501

b:56.1
occ:1.00
 OE1 F:GLN463 2.7 51.6 1.0
O F:THR370 2.8 53.4 1.0
O F:CYS373 2.8 43.8 1.0
O F:LYS371 3.1 54.7 1.0
C F:LYS371 3.5 54.3 1.0
C F:CYS373 3.7 47.4 1.0
CD F:GLN463 3.7 45.2 1.0
CA F:LYS371 3.9 56.9 1.0
C F:THR370 4.0 55.0 1.0
N F:CYS373 4.0 48.1 1.0
O F:HOH607 4.0 57.3 1.0
NE2 F:GLN463 4.1 47.6 1.0
N F:MET372 4.3 55.5 1.0
N F:ASP374 4.4 46.9 1.0
N F:LYS371 4.4 58.0 1.0
CA F:CYS373 4.5 50.2 1.0
C F:MET372 4.5 40.3 1.0
CD F:PRO375 4.5 57.7 1.0
CA F:ASP374 4.7 42.9 1.0
CA F:MET372 4.8 50.5 1.0
CG F:PRO375 5.0 58.3 1.0

Potassium binding site 2 out of 5 in 6of8

Go back to Potassium Binding Sites List in 6of8
Potassium binding site 2 out of 5 in the Structure of THR354ASN, GLU355GLN, THR412ASN, ILE414MET, ILE464HIS, and PHE467MET Mutant Human Camkii-Alpha Hub Domain


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Structure of THR354ASN, GLU355GLN, THR412ASN, ILE414MET, ILE464HIS, and PHE467MET Mutant Human Camkii-Alpha Hub Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
F:K502

b:82.8
occ:1.00
 O F:GLY391 2.7 66.5 1.0
O F:VAL389 2.9 40.4 1.0
O F:HOH601 3.3 61.8 1.0
O F:MET377 3.3 49.5 1.0
CE F:MET377 3.5 39.5 1.0
C F:VAL389 3.6 48.8 1.0
N F:GLY391 3.6 57.6 1.0
CB F:ALA379 3.7 38.9 1.0
N F:ALA379 3.7 41.3 1.0
C F:GLY391 3.8 68.6 1.0
CG2 F:VAL389 3.8 53.2 1.0
C F:THR378 3.8 43.6 1.0
C F:GLU390 3.8 64.9 1.0
CA F:THR378 3.9 46.1 1.0
CA F:GLU390 3.9 55.4 1.0
N F:GLU390 4.0 55.8 1.0
C F:MET377 4.0 41.0 1.0
N F:THR378 4.2 42.9 1.0
CE1 F:HIS395 4.3 69.5 1.0
ND1 F:HIS395 4.3 69.7 1.0
CA F:GLY391 4.3 54.1 1.0
CG F:MET377 4.3 47.2 1.0
CA F:ALA379 4.3 42.5 1.0
CB F:VAL389 4.4 51.2 1.0
O F:THR378 4.4 35.7 1.0
O F:GLU390 4.5 56.0 1.0
SD F:MET377 4.6 61.0 1.0
CA F:VAL389 4.6 40.8 1.0
N F:LEU392 5.0 72.3 1.0

Potassium binding site 3 out of 5 in 6of8

Go back to Potassium Binding Sites List in 6of8
Potassium binding site 3 out of 5 in the Structure of THR354ASN, GLU355GLN, THR412ASN, ILE414MET, ILE464HIS, and PHE467MET Mutant Human Camkii-Alpha Hub Domain


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Structure of THR354ASN, GLU355GLN, THR412ASN, ILE414MET, ILE464HIS, and PHE467MET Mutant Human Camkii-Alpha Hub Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
E:K502

b:56.7
occ:1.00
 OE1 E:GLN463 2.7 48.0 1.0
O E:CYS373 2.8 44.3 1.0
O E:THR370 2.8 55.0 1.0
O E:LYS371 3.1 47.4 1.0
C E:LYS371 3.5 49.6 1.0
C E:CYS373 3.6 52.2 1.0
CD E:GLN463 3.7 48.9 1.0
CA E:LYS371 3.9 50.5 1.0
N E:CYS373 3.9 45.1 1.0
C E:THR370 3.9 54.0 1.0
NE2 E:GLN463 4.0 52.4 1.0
N E:MET372 4.3 47.8 1.0
C E:MET372 4.4 44.6 1.0
N E:LYS371 4.4 55.7 1.0
CA E:CYS373 4.4 49.7 1.0
N E:ASP374 4.4 47.3 1.0
CD E:PRO375 4.6 51.1 1.0
CA E:ASP374 4.7 42.8 1.0
CA E:MET372 4.7 47.6 1.0
O E:MET372 5.0 41.6 1.0

Potassium binding site 4 out of 5 in 6of8

Go back to Potassium Binding Sites List in 6of8
Potassium binding site 4 out of 5 in the Structure of THR354ASN, GLU355GLN, THR412ASN, ILE414MET, ILE464HIS, and PHE467MET Mutant Human Camkii-Alpha Hub Domain


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Structure of THR354ASN, GLU355GLN, THR412ASN, ILE414MET, ILE464HIS, and PHE467MET Mutant Human Camkii-Alpha Hub Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K502

b:69.3
occ:1.00
 O A:CYS373 2.8 55.1 1.0
O A:THR370 2.8 59.4 1.0
OE1 A:GLN463 2.9 67.5 1.0
O A:LYS371 3.2 61.7 1.0
NE2 A:GLN463 3.4 61.8 1.0
CD A:GLN463 3.5 63.0 1.0
C A:LYS371 3.7 60.3 1.0
C A:CYS373 3.8 53.8 1.0
NZ A:LYS461 3.8 90.1 1.0
C A:THR370 4.0 62.5 1.0
CA A:LYS371 4.1 70.3 1.0
N A:CYS373 4.1 57.8 1.0
N A:MET372 4.5 59.3 1.0
N A:LYS371 4.5 68.6 1.0
CA A:CYS373 4.6 51.2 1.0
N A:ASP374 4.6 54.4 1.0
C A:MET372 4.6 52.8 1.0
CD A:PRO375 4.7 55.1 1.0
CA A:ASP374 4.8 53.5 1.0
CE A:LYS461 4.8 86.1 1.0
CA A:MET372 4.9 60.2 1.0

Potassium binding site 5 out of 5 in 6of8

Go back to Potassium Binding Sites List in 6of8
Potassium binding site 5 out of 5 in the Structure of THR354ASN, GLU355GLN, THR412ASN, ILE414MET, ILE464HIS, and PHE467MET Mutant Human Camkii-Alpha Hub Domain


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of Structure of THR354ASN, GLU355GLN, THR412ASN, ILE414MET, ILE464HIS, and PHE467MET Mutant Human Camkii-Alpha Hub Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
D:K501

b:72.3
occ:1.00
 O D:CYS373 2.8 66.8 1.0
O D:THR370 2.9 70.1 1.0
O D:LYS371 3.0 56.9 1.0
OE1 D:GLN463 3.0 67.3 1.0
C D:LYS371 3.6 69.4 1.0
C D:CYS373 3.8 62.1 1.0
CD D:GLN463 3.9 58.4 1.0
NE2 D:GLN463 4.0 57.2 1.0
CA D:LYS371 4.0 74.5 1.0
C D:THR370 4.1 68.6 1.0
N D:CYS373 4.1 64.2 1.0
N D:MET372 4.5 64.3 1.0
N D:LYS371 4.5 67.2 1.0
CA D:CYS373 4.6 59.9 1.0
C D:MET372 4.6 62.2 1.0
N D:ASP374 4.7 60.4 1.0
CD D:PRO375 4.9 61.2 1.0
CA D:ASP374 4.9 51.5 1.0
CA D:MET372 4.9 65.8 1.0

Reference:

E.D.Mcspadden, Z.Xia, C.C.Chi, A.C.Susa, N.H.Shah, C.L.Gee, E.R.Williams, J.Kuriyan. Variation in Assembly Stoichiometry in Non-Metazoan Homologs of the Hub Domain of CA2+/Calmodulin-Dependent Protein Kinase II. Protein Sci. V. 28 1071 2019.
ISSN: ESSN 1469-896X
PubMed: 30942928
DOI: 10.1002/PRO.3614
Page generated: Mon Aug 12 17:03:35 2024

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