Potassium in PDB 6nfv: Structure of the Kcsa-G77C Mutant or the 2,4-Ion Bound Configuration of A K+ Channel Selectivity Filter.

The structure of Structure of the Kcsa-G77C Mutant or the 2,4-Ion Bound Configuration of A K+ Channel Selectivity Filter., PDB code: 6nfv was solved by C.Tilegenova, D.M.Cortes, N.Jahovic, E.Hardy, H.Parameswaran, L.Guan, L.G.Cuello, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	34.92 / 2.13
Space group	I 4
Cell size a, b, c (Å), α, β, γ (°)	156.158, 156.158, 76.116, 90.00, 90.00, 90.00
R / Rfree (%)	20.6 / 24.3

The binding sites of Potassium atom in the Structure of the Kcsa-G77C Mutant or the 2,4-Ion Bound Configuration of A K+ Channel Selectivity Filter. (pdb code 6nfv). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 4 binding sites of Potassium where determined in the Structure of the Kcsa-G77C Mutant or the 2,4-Ion Bound Configuration of A K+ Channel Selectivity Filter., PDB code: 6nfv:
Jump to Potassium binding site number: 1; 2; 3; 4;

Potassium binding site 1 out of 4 in the Structure of the Kcsa-G77C Mutant or the 2,4-Ion Bound Configuration of A K+ Channel Selectivity Filter.


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Structure of the Kcsa-G77C Mutant or the 2,4-Ion Bound Configuration of A K+ Channel Selectivity Filter. within 5.0Å range: probe atom residue distance (Å) B Occ C:K202 b:43.5 occ:0.25 O C:HOH312 2.8 51.9 0.2 OG1 C:THR75 2.9 40.3 1.0 O C:THR75 3.0 42.3 1.0 CB C:THR75 3.5 38.0 1.0 C C:THR75 3.9 42.4 1.0 CA C:THR75 4.3 39.8 1.0 CG2 C:THR75 4.7 38.7 1.0 N C:VAL76 4.9 41.6 1.0

Potassium binding site 2 out of 4 in the Structure of the Kcsa-G77C Mutant or the 2,4-Ion Bound Configuration of A K+ Channel Selectivity Filter.


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Structure of the Kcsa-G77C Mutant or the 2,4-Ion Bound Configuration of A K+ Channel Selectivity Filter. within 5.0Å range: probe atom residue distance (Å) B Occ C:K203 b:50.8 occ:0.25 O C:CYS77 2.7 46.1 1.0 O C:HOH316 3.1 57.4 0.2 O C:HOH312 3.6 51.9 0.2 C C:CYS77 3.8 41.7 1.0 CB C:CYS77 4.2 52.4 0.5 CB C:CYS77 4.2 52.4 0.5 CA C:CYS77 4.4 46.8 0.5 CA C:CYS77 4.4 46.8 0.5 SG C:CYS77 4.4 55.3 0.5 N C:CYS77 4.5 44.0 1.0 N C:TYR78 4.9 41.4 1.0

Potassium binding site 3 out of 4 in the Structure of the Kcsa-G77C Mutant or the 2,4-Ion Bound Configuration of A K+ Channel Selectivity Filter.


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Structure of the Kcsa-G77C Mutant or the 2,4-Ion Bound Configuration of A K+ Channel Selectivity Filter. within 5.0Å range: probe atom residue distance (Å) B Occ C:K204 b:44.7 occ:0.25 O C:HOH317 3.1 73.1 1.0 O C:HOH318 3.3 63.4 1.0

Potassium binding site 4 out of 4 in the Structure of the Kcsa-G77C Mutant or the 2,4-Ion Bound Configuration of A K+ Channel Selectivity Filter.


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Structure of the Kcsa-G77C Mutant or the 2,4-Ion Bound Configuration of A K+ Channel Selectivity Filter. within 5.0Å range: probe atom residue distance (Å) B Occ C:K205 b:0.1 occ:0.25 O C:HOH316 4.4 57.4 0.2 O C:TYR78 4.7 46.8 1.0 CA C:GLY79 4.8 37.8 1.0 O C:GLY79 4.8 43.7 1.0 O C:HOH302 4.8 59.1 1.0

C.Tilegenova, D.M.Cortes, N.Jahovic, E.Hardy, P.Hariharan, L.Guan, L.G.Cuello. Structure, Function, and Ion-Binding Properties of A K+Channel Stabilized in the 2,4-Ion-Bound Configuration. Proc.Natl.Acad.Sci.Usa V. 116 16829 2019.
ISSN: ESSN 1091-6490
PubMed: 31387976
DOI: 10.1073/PNAS.1901888116