Potassium in PDB 6nfu: Structure of the Kcsa-G77A Mutant or the 2,4-Ion Bound Configuration of A K+ Channel Selectivity Filter.

The structure of Structure of the Kcsa-G77A Mutant or the 2,4-Ion Bound Configuration of A K+ Channel Selectivity Filter., PDB code: 6nfu was solved by C.Tilegenova, D.M.Cortes, N.Jahovic, E.Hardy, H.Parameswaran, L.Guan, L.G.Cuello, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	34.68 / 2.09
Space group	I 4
Cell size a, b, c (Å), α, β, γ (°)	155.086, 155.086, 75.794, 90.00, 90.00, 90.00
R / Rfree (%)	21 / 22.4

The binding sites of Potassium atom in the Structure of the Kcsa-G77A Mutant or the 2,4-Ion Bound Configuration of A K+ Channel Selectivity Filter. (pdb code 6nfu). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 4 binding sites of Potassium where determined in the Structure of the Kcsa-G77A Mutant or the 2,4-Ion Bound Configuration of A K+ Channel Selectivity Filter., PDB code: 6nfu:
Jump to Potassium binding site number: 1; 2; 3; 4;

Potassium binding site 1 out of 4 in the Structure of the Kcsa-G77A Mutant or the 2,4-Ion Bound Configuration of A K+ Channel Selectivity Filter.


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Structure of the Kcsa-G77A Mutant or the 2,4-Ion Bound Configuration of A K+ Channel Selectivity Filter. within 5.0Å range: probe atom residue distance (Å) B Occ C:K1002 b:55.4 occ:0.25 O C:HOH1125 2.9 43.5 1.0 O C:HOH1136 4.8 36.0 0.2 O C:TYR78 4.8 28.5 1.0 O C:GLY79 5.0 26.8 1.0

Potassium binding site 2 out of 4 in the Structure of the Kcsa-G77A Mutant or the 2,4-Ion Bound Configuration of A K+ Channel Selectivity Filter.


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Structure of the Kcsa-G77A Mutant or the 2,4-Ion Bound Configuration of A K+ Channel Selectivity Filter. within 5.0Å range: probe atom residue distance (Å) B Occ C:K1003 b:32.5 occ:0.25 O C:ALA77 2.7 24.6 1.0 O C:HOH1134 2.9 39.4 0.2 O C:HOH1136 2.9 36.0 0.2 C C:ALA77 3.8 26.3 1.0 CB C:ALA77 4.4 30.9 1.0 CA C:ALA77 4.5 27.9 1.0 N C:ALA77 4.5 25.4 1.0 N C:TYR78 4.8 24.7 1.0

Potassium binding site 3 out of 4 in the Structure of the Kcsa-G77A Mutant or the 2,4-Ion Bound Configuration of A K+ Channel Selectivity Filter.


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Structure of the Kcsa-G77A Mutant or the 2,4-Ion Bound Configuration of A K+ Channel Selectivity Filter. within 5.0Å range: probe atom residue distance (Å) B Occ C:K1004 b:28.3 occ:0.25 OG1 C:THR75 2.9 25.1 1.0 O C:THR75 2.9 24.7 1.0 O C:HOH1134 3.4 39.4 0.2 CB C:THR75 3.5 22.9 1.0 O C:HOH1137 3.8 47.7 0.2 C C:THR75 3.9 26.1 1.0 CA C:THR75 4.3 23.5 1.0 CG2 C:THR75 4.7 23.3 1.0 N C:VAL76 4.9 24.6 1.0

Potassium binding site 4 out of 4 in the Structure of the Kcsa-G77A Mutant or the 2,4-Ion Bound Configuration of A K+ Channel Selectivity Filter.


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Structure of the Kcsa-G77A Mutant or the 2,4-Ion Bound Configuration of A K+ Channel Selectivity Filter. within 5.0Å range: probe atom residue distance (Å) B Occ C:K1005 b:29.8 occ:0.25 O C:HOH1148 3.1 52.6 1.0 O C:HOH1150 3.1 54.2 0.2 O C:HOH1149 3.4 48.8 1.0 O C:HOH1137 3.9 47.7 0.2

C.Tilegenova, D.M.Cortes, N.Jahovic, E.Hardy, P.Hariharan, L.Guan, L.G.Cuello. Structure, Function, and Ion-Binding Properties of A K+Channel Stabilized in the 2,4-Ion-Bound Configuration. Proc.Natl.Acad.Sci.Usa V. 116 16829 2019.
ISSN: ESSN 1091-6490
PubMed: 31387976
DOI: 10.1073/PNAS.1901888116