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Potassium in PDB 6cq6: K2P2.1(Trek-1) Apo Structure

Protein crystallography data

The structure of K2P2.1(Trek-1) Apo Structure, PDB code: 6cq6 was solved by M.Lolicato, D.L.Minor, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 14.97 / 3.10
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 66.718, 120.417, 126.440, 90.00, 90.00, 90.00
R / Rfree (%) 26 / 30.2

Other elements in 6cq6:

The structure of K2P2.1(Trek-1) Apo Structure also contains other interesting chemical elements:

Cadmium (Cd) 3 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the K2P2.1(Trek-1) Apo Structure (pdb code 6cq6). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 6 binding sites of Potassium where determined in the K2P2.1(Trek-1) Apo Structure, PDB code: 6cq6:
Jump to Potassium binding site number: 1; 2; 3; 4; 5; 6;

Potassium binding site 1 out of 6 in 6cq6

Go back to Potassium Binding Sites List in 6cq6
Potassium binding site 1 out of 6 in the K2P2.1(Trek-1) Apo Structure


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of K2P2.1(Trek-1) Apo Structure within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K402

b:0.7
occ:1.00
 O A:PHE254 4.5 0.5 1.0
O A:PHE145 4.7 0.3 1.0
O B:PHE254 4.8 0.3 1.0
O B:GLY146 4.8 0.5 1.0
O A:GLY146 4.9 0.7 1.0
C A:GLY146 4.9 0.3 1.0
N A:ASN147 4.9 0.4 1.0
O A:GLY255 4.9 0.1 1.0
CA A:ASN147 4.9 0.1 1.0
C A:GLY255 5.0 0.3 1.0

Potassium binding site 2 out of 6 in 6cq6

Go back to Potassium Binding Sites List in 6cq6
Potassium binding site 2 out of 6 in the K2P2.1(Trek-1) Apo Structure


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of K2P2.1(Trek-1) Apo Structure within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K403

b:0.2
occ:1.00
 O B:PHE254 2.7 0.3 1.0
O A:PHE145 2.7 0.3 1.0
O A:PHE254 2.7 0.5 1.0
O A:GLY253 2.8 0.2 1.0
O A:GLY144 2.8 0.8 1.0
O B:GLY253 3.0 0.5 1.0
O B:GLY144 3.0 0.2 1.0
K A:K404 3.1 0.0 1.0
C A:PHE145 3.2 0.1 1.0
O B:PHE145 3.2 0.6 1.0
C B:PHE254 3.3 0.1 1.0
C A:PHE254 3.4 0.3 1.0
C B:PHE145 3.6 0.8 1.0
CA B:PHE254 3.8 0.8 1.0
CA A:PHE145 3.8 87.0 1.0
N A:GLY146 3.9 0.0 1.0
C A:GLY144 3.9 0.1 1.0
C A:GLY253 4.0 0.5 1.0
CA A:PHE254 4.0 0.7 1.0
C B:GLY253 4.1 0.3 1.0
C B:GLY144 4.2 0.9 1.0
N B:GLY255 4.2 0.5 1.0
CA B:PHE145 4.2 98.7 1.0
CA A:GLY146 4.2 0.9 1.0
N A:GLY255 4.2 0.9 1.0
N B:GLY146 4.3 0.5 1.0
N A:PHE145 4.4 0.8 1.0
N B:PHE254 4.4 0.1 1.0
N A:PHE254 4.5 0.7 1.0
CA B:GLY146 4.6 0.4 1.0
CA A:GLY255 4.6 0.1 1.0
CA B:GLY255 4.7 0.6 1.0
N B:PHE145 4.7 0.3 1.0

Potassium binding site 3 out of 6 in 6cq6

Go back to Potassium Binding Sites List in 6cq6
Potassium binding site 3 out of 6 in the K2P2.1(Trek-1) Apo Structure


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of K2P2.1(Trek-1) Apo Structure within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K404

b:0.0
occ:1.00
 O B:GLY144 2.6 0.2 1.0
O A:GLY144 2.6 0.8 1.0
O B:ILE252 2.7 0.8 1.0
O A:ILE252 2.7 82.1 1.0
O A:GLY253 2.7 0.2 1.0
O B:GLY253 2.7 0.5 1.0
O B:ILE143 2.7 0.0 1.0
O A:ILE143 2.7 1.0 1.0
K A:K403 3.1 0.2 1.0
K A:K405 3.1 0.2 1.0
C B:GLY144 3.5 0.9 1.0
C A:GLY144 3.5 0.1 1.0
C B:GLY253 3.5 0.3 1.0
C A:GLY253 3.6 0.5 1.0
C A:ILE252 3.8 0.9 1.0
C B:ILE252 3.8 0.3 1.0
C B:ILE143 3.8 98.9 1.0
C A:ILE143 3.9 0.1 1.0
CA B:GLY144 4.0 86.9 1.0
CA A:GLY253 4.1 89.4 1.0
CA A:GLY144 4.1 0.4 1.0
CA B:GLY253 4.2 0.5 1.0
N B:GLY144 4.4 99.1 1.0
N A:PHE145 4.4 0.8 1.0
N A:GLY253 4.4 90.7 1.0
N B:PHE145 4.4 0.3 1.0
N B:PHE254 4.5 0.1 1.0
N A:GLY144 4.5 98.8 1.0
N B:GLY253 4.5 96.1 1.0
N A:PHE254 4.5 0.7 1.0
CA B:PHE254 4.7 0.8 1.0
CA A:PHE145 4.7 87.0 1.0
CA B:PHE145 4.8 98.7 1.0
CA A:PHE254 4.9 0.7 1.0
O B:THR142 4.9 0.8 1.0
C A:PHE145 5.0 0.1 1.0
O A:THR142 5.0 0.1 1.0
C B:PHE254 5.0 0.1 1.0

Potassium binding site 4 out of 6 in 6cq6

Go back to Potassium Binding Sites List in 6cq6
Potassium binding site 4 out of 6 in the K2P2.1(Trek-1) Apo Structure


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of K2P2.1(Trek-1) Apo Structure within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K405

b:0.2
occ:1.00
 O A:THR251 2.6 76.4 1.0
O A:THR142 2.6 0.1 1.0
O B:THR142 2.6 0.8 1.0
O A:ILE143 2.7 1.0 1.0
O B:THR251 2.7 0.0 1.0
O B:ILE143 2.8 0.0 1.0
O B:ILE252 2.8 0.8 1.0
O A:ILE252 2.8 82.1 1.0
K A:K404 3.1 0.0 1.0
C A:ILE143 3.4 0.1 1.0
C B:ILE143 3.5 98.9 1.0
C B:ILE252 3.5 0.3 1.0
C A:ILE252 3.6 0.9 1.0
K B:K401 3.7 0.0 1.0
C B:THR251 3.7 0.1 1.0
C A:THR251 3.7 87.0 1.0
C A:THR142 3.8 0.9 1.0
C B:THR142 3.8 94.4 1.0
CA B:ILE252 3.8 0.1 1.0
CA A:ILE143 3.8 93.8 1.0
CA B:ILE143 3.9 81.4 1.0
CA A:ILE252 3.9 85.6 1.0
N B:ILE252 4.2 99.7 1.0
N A:ILE143 4.3 84.4 1.0
N A:ILE252 4.3 80.4 1.0
N B:ILE143 4.3 77.4 1.0
N A:GLY144 4.4 98.8 1.0
OG1 B:THR251 4.5 1.0 1.0
N B:GLY144 4.5 99.1 1.0
N B:GLY253 4.6 96.1 1.0
N A:GLY253 4.6 90.7 1.0
CA B:THR251 4.9 89.6 1.0
CA A:THR251 4.9 81.2 1.0
CA A:GLY144 4.9 0.4 1.0
O A:GLY144 4.9 0.8 1.0
CA A:THR142 5.0 87.7 1.0
CA B:GLY144 5.0 86.9 1.0

Potassium binding site 5 out of 6 in 6cq6

Go back to Potassium Binding Sites List in 6cq6
Potassium binding site 5 out of 6 in the K2P2.1(Trek-1) Apo Structure


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of K2P2.1(Trek-1) Apo Structure within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K406

b:0.1
occ:1.00
 OG1 A:THR251 3.7 0.2 1.0
CG2 B:THR142 4.4 85.2 1.0
O A:THR250 4.6 0.3 1.0
OG1 B:THR142 4.8 0.9 1.0
CG2 A:THR251 4.8 87.2 1.0
CB A:THR251 4.8 91.5 1.0
CD1 A:LEU289 5.0 93.9 1.0

Potassium binding site 6 out of 6 in 6cq6

Go back to Potassium Binding Sites List in 6cq6
Potassium binding site 6 out of 6 in the K2P2.1(Trek-1) Apo Structure


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 6 of K2P2.1(Trek-1) Apo Structure within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K401

b:0.0
occ:1.00
 OG1 B:THR251 2.7 1.0 1.0
O A:THR251 2.7 76.4 1.0
OG1 A:THR251 2.8 0.2 1.0
O B:THR251 2.9 0.0 1.0
OG1 B:THR142 3.0 0.9 1.0
CB A:THR251 3.0 91.5 1.0
OG1 A:THR142 3.1 0.4 1.0
CG2 B:THR251 3.2 90.0 1.0
O B:THR142 3.3 0.8 1.0
CB B:THR142 3.3 74.6 1.0
O A:THR142 3.5 0.1 1.0
CB B:THR251 3.5 83.4 1.0
C A:THR251 3.5 87.0 1.0
CB A:THR142 3.7 76.6 1.0
K A:K405 3.7 0.2 1.0
CA A:THR251 3.9 81.2 1.0
C B:THR142 3.9 94.4 1.0
C B:THR251 4.0 0.1 1.0
C A:THR142 4.1 0.9 1.0
CG2 A:THR251 4.2 87.2 1.0
CA B:THR142 4.3 88.7 1.0
CA B:THR251 4.4 89.6 1.0
CG2 B:THR142 4.4 85.2 1.0
CA A:THR142 4.5 87.7 1.0
O A:THR250 4.5 0.3 1.0
N A:ILE252 4.6 80.4 1.0
N A:ILE143 4.8 84.4 1.0
CG2 A:THR142 4.8 79.2 1.0
O B:THR141 4.9 0.0 1.0
N B:ILE143 4.9 77.4 1.0
O A:THR141 5.0 83.7 1.0

Reference:

M.Lolicato, C.Arrigoni, T.Mori, Y.Sekioka, C.Bryant, K.A.Clark, D.L.Minor. K2P2.1 (Trek-1)-Activator Complexes Reveal A Cryptic Selectivity Filter Binding Site. Nature V. 547 364 2017.
ISSN: ESSN 1476-4687
PubMed: 28693035
DOI: 10.1038/NATURE22988
Page generated: Mon Dec 14 00:27:23 2020

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