Potassium in PDB 6by3: Open and Conductive Conformation of Kcsa-T75A Mutant

The structure of Open and Conductive Conformation of Kcsa-T75A Mutant, PDB code: 6by3 was solved by A.J.Labro, D.M.Cortes, C.Tilegenova, L.G.Cuello, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	36.80 / 2.37
Space group	I 4
Cell size a, b, c (Å), α, β, γ (°)	156.126, 156.126, 74.479, 90.00, 90.00, 90.00
R / Rfree (%)	20.5 / 21.9

The binding sites of Potassium atom in the Open and Conductive Conformation of Kcsa-T75A Mutant (pdb code 6by3). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 6 binding sites of Potassium where determined in the Open and Conductive Conformation of Kcsa-T75A Mutant, PDB code: 6by3:
Jump to Potassium binding site number: 1; 2; 3; 4; 5; 6;

Potassium binding site 1 out of 6 in the Open and Conductive Conformation of Kcsa-T75A Mutant


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Open and Conductive Conformation of Kcsa-T75A Mutant within 5.0Å range: probe atom residue distance (Å) B Occ C:K1002 b:32.3 occ:0.25 O C:TYR78 2.9 32.8 1.0 O C:GLY77 3.0 33.4 1.0 K C:K1003 3.4 34.1 0.2 C C:TYR78 3.5 34.7 1.0 CA C:TYR78 4.1 33.4 1.0 C C:GLY77 4.1 35.8 1.0 N C:GLY79 4.2 27.1 1.0 CA C:GLY79 4.5 33.5 1.0 N C:TYR78 4.6 31.9 1.0 K C:K1005 4.7 97.4 0.2

Potassium binding site 2 out of 6 in the Open and Conductive Conformation of Kcsa-T75A Mutant


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Open and Conductive Conformation of Kcsa-T75A Mutant within 5.0Å range: probe atom residue distance (Å) B Occ C:K1003 b:34.1 occ:0.25 O C:GLY77 2.8 33.4 1.0 O C:VAL76 2.9 26.6 1.0 K C:K1004 3.3 40.1 0.2 K C:K1002 3.4 32.3 0.2 C C:GLY77 3.6 35.8 1.0 C C:VAL76 4.0 34.4 1.0 CA C:GLY77 4.1 35.9 1.0 N C:GLY77 4.5 35.8 1.0 N C:TYR78 4.6 31.9 1.0 CA C:TYR78 4.9 33.4 1.0

Potassium binding site 3 out of 6 in the Open and Conductive Conformation of Kcsa-T75A Mutant


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Open and Conductive Conformation of Kcsa-T75A Mutant within 5.0Å range: probe atom residue distance (Å) B Occ C:K1004 b:40.1 occ:0.25 O C:ALA75 2.8 39.3 1.0 O C:VAL76 3.0 26.6 1.0 K C:K1003 3.3 34.1 0.2 O C:HOH1116 3.5 48.9 0.2 C C:VAL76 3.7 34.4 1.0 C C:ALA75 3.9 29.4 1.0 CA C:VAL76 4.1 30.2 1.0 N C:VAL76 4.5 35.6 1.0 N C:GLY77 4.8 35.8 1.0

Potassium binding site 4 out of 6 in the Open and Conductive Conformation of Kcsa-T75A Mutant


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Open and Conductive Conformation of Kcsa-T75A Mutant within 5.0Å range: probe atom residue distance (Å) B Occ C:K1005 b:97.4 occ:0.25 O C:HOH1117 2.8 68.9 1.0 K C:K1006 3.0 96.6 0.2 O C:TYR78 4.3 32.8 1.0 O C:HOH1118 4.3 72.1 1.0 K C:K1002 4.7 32.3 0.2 O C:GLY79 4.8 36.6 1.0

Potassium binding site 5 out of 6 in the Open and Conductive Conformation of Kcsa-T75A Mutant


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of Open and Conductive Conformation of Kcsa-T75A Mutant within 5.0Å range: probe atom residue distance (Å) B Occ C:K1006 b:96.6 occ:0.25 K C:K1005 3.0 97.4 0.2 O C:HOH1118 3.5 72.1 1.0 O C:HOH1117 3.6 68.9 1.0

Potassium binding site 6 out of 6 in the Open and Conductive Conformation of Kcsa-T75A Mutant


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 6 of Open and Conductive Conformation of Kcsa-T75A Mutant within 5.0Å range:

A.J.Labro, D.M.Cortes, C.Tilegenova, L.G.Cuello. Inverted Allosteric Coupling Between Activation and Inactivation Gates in K+Channels. Proc. Natl. Acad. Sci. V. 115 5426 2018U.S.A..
ISSN: ESSN 1091-6490
PubMed: 29735651
DOI: 10.1073/PNAS.1800559115