Potassium in PDB 4pkl: Bromodomain of Trypanosoma Brucei BDF2 with Ibet-151

The structure of Bromodomain of Trypanosoma Brucei BDF2 with Ibet-151, PDB code: 4pkl was solved by E.W.Debler, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	31.06 / 1.25
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	55.869, 62.091, 62.117, 90.00, 90.00, 90.00
R / Rfree (%)	16.9 / 17.9

The structure of Bromodomain of Trypanosoma Brucei BDF2 with Ibet-151 also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Potassium atom in the Bromodomain of Trypanosoma Brucei BDF2 with Ibet-151 (pdb code 4pkl). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Bromodomain of Trypanosoma Brucei BDF2 with Ibet-151, PDB code: 4pkl:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the Bromodomain of Trypanosoma Brucei BDF2 with Ibet-151


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Bromodomain of Trypanosoma Brucei BDF2 with Ibet-151 within 5.0Å range: probe atom residue distance (Å) B Occ A:K203 b:17.1 occ:1.00 O A:ASN86 2.6 15.8 1.0 O A:LEU83 2.7 15.6 1.0 O A:HOH360 2.8 25.1 1.0 O A:GLU84 2.8 15.5 1.0 O A:HOH420 3.0 40.3 1.0 C A:GLU84 3.5 13.3 1.0 C A:ASN86 3.7 13.0 1.0 CA A:GLU84 3.8 15.2 1.0 C A:LEU83 3.8 14.3 1.0 CL A:CL204 4.0 39.0 1.0 N A:GLU84 4.3 13.9 1.0 CA A:ALA87 4.4 15.0 1.0 CE2 A:TYR93 4.5 18.6 1.0 N A:ASN86 4.5 13.7 1.0 N A:TYR85 4.5 13.7 1.0 N A:ALA87 4.5 14.2 1.0 C A:TYR85 4.6 13.1 1.0 N A:LYS88 4.7 16.0 1.0 CA A:ASN86 4.7 13.0 1.0 CD2 A:TYR93 4.8 15.6 1.0 O A:TYR85 4.8 13.6 1.0 C A:ALA87 4.9 14.2 1.0 O A:HOH344 4.9 14.2 1.0

Potassium binding site 2 out of 2 in the Bromodomain of Trypanosoma Brucei BDF2 with Ibet-151


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Bromodomain of Trypanosoma Brucei BDF2 with Ibet-151 within 5.0Å range: probe atom residue distance (Å) B Occ B:K202 b:25.6 occ:1.00 O B:ASN86 2.7 15.0 1.0 O B:LEU83 2.7 15.1 1.0 O B:HOH391 2.8 38.2 1.0 O B:HOH348 2.9 40.0 1.0 O B:GLU84 2.9 16.6 1.0 C B:GLU84 3.6 15.6 1.0 C B:LEU83 3.8 12.3 1.0 C B:ASN86 3.8 13.4 1.0 CA B:GLU84 3.9 15.1 1.0 NZ B:LYS88 4.1 34.9 1.0 CE2 B:TYR93 4.3 15.1 1.0 N B:ASN86 4.3 11.7 1.0 N B:GLU84 4.4 12.7 1.0 C B:TYR85 4.4 13.1 1.0 N B:TYR85 4.5 12.9 1.0 CD2 B:TYR93 4.5 14.5 1.0 O B:TYR85 4.6 14.7 1.0 CG B:LYS88 4.6 23.9 1.0 CA B:ASN86 4.7 12.1 1.0 N B:LYS88 4.7 14.9 1.0 N B:ALA87 4.8 13.7 1.0 O B:HOH330 4.8 27.5 1.0 CA B:ALA87 4.8 14.1 1.0 C B:ALA87 4.9 13.5 1.0 CA B:TYR85 5.0 14.9 1.0 CE B:LYS88 5.0 30.0 1.0

D.Schulz, M.Mugnier, E.Paulsen, H.Kim, C.Chung, D.F.Tough, I.Rioja, R.K.Prinjha, N.Papavasiliou, E.W.Debler. Bromodomain Proteins Regulate Mono- Allelic Expression and Switching of T. Brucei Variant Surface Glycoprotein To Be Published.