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Potassium in PDB 4c1l: Crystal Structure of Pyrococcus Furiosus 3-Deoxy-D-Arabino- Heptulosonate 7-Phosphate Synthase I181D Interface Mutant

Enzymatic activity of Crystal Structure of Pyrococcus Furiosus 3-Deoxy-D-Arabino- Heptulosonate 7-Phosphate Synthase I181D Interface Mutant

All present enzymatic activity of Crystal Structure of Pyrococcus Furiosus 3-Deoxy-D-Arabino- Heptulosonate 7-Phosphate Synthase I181D Interface Mutant:
2.5.1.54;

Protein crystallography data

The structure of Crystal Structure of Pyrococcus Furiosus 3-Deoxy-D-Arabino- Heptulosonate 7-Phosphate Synthase I181D Interface Mutant, PDB code: 4c1l was solved by A.R.Nazmi, L.R.Schofield, R.C.J.Dobson, G.B.Jameson, E.J.Parker, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 43.97 / 1.80
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 87.942, 110.923, 143.531, 90.00, 90.00, 90.00
R / Rfree (%) 16.419 / 18.331

Other elements in 4c1l:

The structure of Crystal Structure of Pyrococcus Furiosus 3-Deoxy-D-Arabino- Heptulosonate 7-Phosphate Synthase I181D Interface Mutant also contains other interesting chemical elements:

Manganese (Mn) 2 atoms
Chlorine (Cl) 4 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the Crystal Structure of Pyrococcus Furiosus 3-Deoxy-D-Arabino- Heptulosonate 7-Phosphate Synthase I181D Interface Mutant (pdb code 4c1l). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Crystal Structure of Pyrococcus Furiosus 3-Deoxy-D-Arabino- Heptulosonate 7-Phosphate Synthase I181D Interface Mutant, PDB code: 4c1l:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in 4c1l

Go back to Potassium Binding Sites List in 4c1l
Potassium binding site 1 out of 2 in the Crystal Structure of Pyrococcus Furiosus 3-Deoxy-D-Arabino- Heptulosonate 7-Phosphate Synthase I181D Interface Mutant


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of Pyrococcus Furiosus 3-Deoxy-D-Arabino- Heptulosonate 7-Phosphate Synthase I181D Interface Mutant within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K1265

b:25.1
occ:0.50
 O A:HOH2172 2.0 20.9 0.5
O A:THR170 2.5 12.1 1.0
O A:HOH2174 2.6 27.8 1.0
O A:HOH2170 2.7 33.5 1.0
O A:HOH2171 2.8 18.7 1.0
O A:GLU172 2.8 16.7 1.0
O A:HOH2168 3.4 35.8 1.0
C A:GLU172 3.7 16.4 1.0
C A:THR170 3.7 12.1 1.0
C A:PHE171 4.0 13.1 1.0
N A:GLU172 4.1 13.8 1.0
O A:HOH2173 4.1 23.5 1.0
O A:PHE171 4.3 12.9 1.0
N A:THR170 4.4 11.7 1.0
N A:THR173 4.4 17.2 1.0
CA A:THR173 4.4 20.1 1.0
CA A:PHE171 4.4 12.7 1.0
CG2 A:THR173 4.5 22.7 1.0
N A:PHE171 4.5 12.4 1.0
CA A:GLU172 4.5 14.9 1.0
CA A:THR170 4.7 12.0 1.0
OG1 A:THR170 4.8 12.3 1.0
CD A:ARG169 4.9 12.6 1.0

Potassium binding site 2 out of 2 in 4c1l

Go back to Potassium Binding Sites List in 4c1l
Potassium binding site 2 out of 2 in the Crystal Structure of Pyrococcus Furiosus 3-Deoxy-D-Arabino- Heptulosonate 7-Phosphate Synthase I181D Interface Mutant


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of Pyrococcus Furiosus 3-Deoxy-D-Arabino- Heptulosonate 7-Phosphate Synthase I181D Interface Mutant within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K1268

b:27.4
occ:0.50
 O B:HOH2157 2.4 19.6 0.5
O B:HOH2159 2.5 25.8 1.0
O B:THR170 2.6 12.1 1.0
O B:GLU172 2.7 16.7 1.0
O B:HOH2152 2.7 21.6 1.0
O B:HOH2154 3.0 29.1 1.0
O B:HOH2155 3.1 36.6 1.0
C B:GLU172 3.6 16.0 1.0
C B:THR170 3.8 11.7 1.0
O B:HOH2158 4.0 21.2 1.0
C B:PHE171 4.1 13.2 1.0
N B:GLU172 4.2 13.6 1.0
CA B:THR173 4.3 18.8 1.0
CG2 B:THR173 4.3 22.3 1.0
N B:THR173 4.3 17.0 1.0
N B:THR170 4.4 10.7 1.0
O B:PHE171 4.4 14.3 1.0
CA B:GLU172 4.5 14.4 1.0
CA B:PHE171 4.6 12.5 1.0
N B:PHE171 4.6 12.1 1.0
CA B:THR170 4.8 11.2 1.0
OG1 B:THR170 4.8 10.6 1.0
CD B:ARG169 4.8 12.3 1.0
O B:ARG176 4.9 19.3 0.5
O B:THR175 4.9 17.8 1.0
O B:ARG176 4.9 20.0 0.5
CB B:THR173 4.9 20.3 1.0

Reference:

A.R.Nazmi, L.R.Schofield, R.C.J.Dobson, G.B.Jameson, E.J.Parker. Destabilization of the Homotetrameric Assembly of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase From the Hyperthermophile Pyrococcus Furiosus Enhances Enzymatic Activity J.Mol.Biol. V. 426 656 2014.
ISSN: ISSN 0022-2836
PubMed: 24239948
DOI: 10.1016/J.JMB.2013.11.008
Page generated: Sun Dec 13 23:29:21 2020

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