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Potassium in PDB 4bw5: Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1)

Protein crystallography data

The structure of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1), PDB code: 4bw5 was solved by A.C.W.Pike, Y.Y.Dong, L.Dong, A.Quigley, L.Shrestha, S.Mukhopadhyay, C.Strain-Damerell, S.Goubin, M.Grieben, C.A.Shintre, A.Mackenzie, M.Vollmar, F.Von Delft, C.H.Arrowsmith, A.M.Edwards, C.Bountra, N.Burgess-Brown, E.P.Carpenter, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.57 / 3.20
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 87.830, 96.960, 103.700, 90.00, 92.58, 90.00
R / Rfree (%) 23.7 / 25.4

Other elements in 4bw5:

The structure of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) also contains other interesting chemical elements:

Cadmium (Cd) 2 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) (pdb code 4bw5). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 8 binding sites of Potassium where determined in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1), PDB code: 4bw5:
Jump to Potassium binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Potassium binding site 1 out of 8 in 4bw5

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Potassium binding site 1 out of 8 in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1)


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K600

b:0.7
occ:1.00
 O B:TYR175 2.5 0.1 1.0
O A:TYR175 2.6 98.4 1.0
O B:PHE284 2.7 98.5 1.0
O A:PHE284 2.8 0.9 1.0
O B:GLY283 3.0 94.9 1.0
O A:GLY174 3.0 91.1 1.0
O B:GLY174 3.1 0.5 1.0
O A:GLY283 3.1 94.5 1.0
C B:TYR175 3.2 0.8 1.0
C A:TYR175 3.2 97.4 1.0
K A:K601 3.3 98.0 1.0
C B:PHE284 3.3 97.9 1.0
C A:PHE284 3.5 1.0 1.0
CA B:PHE284 3.8 91.8 1.0
N A:GLY176 3.9 94.8 1.0
N B:GLY176 3.9 0.6 1.0
CA A:PHE284 4.0 96.8 1.0
CA B:TYR175 4.0 96.4 1.0
CA A:GLY176 4.0 95.6 1.0
CA A:TYR175 4.0 91.8 1.0
C B:GLY283 4.1 94.8 1.0
CA B:GLY176 4.1 0.1 1.0
C A:GLY174 4.1 92.1 1.0
C B:GLY174 4.1 0.5 1.0
C A:GLY283 4.2 97.3 1.0
N B:GLY285 4.3 95.3 1.0
N A:GLY285 4.4 0.8 1.0
N B:PHE284 4.4 91.9 1.0
N B:TYR175 4.5 98.0 1.0
N A:TYR175 4.5 90.9 1.0
N A:PHE284 4.5 96.8 1.0
CA B:GLY285 4.7 96.4 1.0
CA A:GLY285 4.8 0.3 1.0
C A:GLY176 4.9 0.2 1.0
C B:GLY176 4.9 0.4 1.0

Potassium binding site 2 out of 8 in 4bw5

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Potassium binding site 2 out of 8 in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1)


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K601

b:98.0
occ:1.00
 O A:GLY174 2.3 91.1 1.0
O B:GLY174 2.4 0.5 1.0
O A:GLY283 2.5 94.5 1.0
O B:GLY283 2.6 94.9 1.0
O A:VAL282 2.7 92.8 1.0
O B:VAL282 2.7 89.8 1.0
O A:ILE173 2.8 91.3 1.0
O B:ILE173 2.8 99.3 1.0
K A:K602 3.1 93.2 1.0
C A:GLY174 3.3 92.1 1.0
C B:GLY174 3.3 0.5 1.0
K A:K600 3.3 0.7 1.0
C A:GLY283 3.4 97.3 1.0
C B:GLY283 3.5 94.8 1.0
C A:VAL282 3.9 95.1 1.0
C A:ILE173 3.9 91.6 1.0
C B:VAL282 3.9 90.3 1.0
CA A:GLY174 3.9 87.5 1.0
CA B:GLY174 3.9 98.6 1.0
C B:ILE173 3.9 0.3 1.0
CA A:GLY283 4.0 93.2 1.0
CA B:GLY283 4.1 89.1 1.0
N A:TYR175 4.2 90.9 1.0
N B:TYR175 4.3 98.0 1.0
N A:GLY174 4.3 88.3 1.0
N B:GLY174 4.4 98.5 1.0
N A:GLY283 4.4 93.4 1.0
N B:GLY283 4.4 88.1 1.0
N A:PHE284 4.5 96.8 1.0
N B:PHE284 4.5 91.9 1.0
CA A:TYR175 4.6 91.8 1.0
CA B:TYR175 4.7 96.4 1.0
CA A:PHE284 4.8 96.8 1.0
CA B:PHE284 4.8 91.8 1.0
C A:TYR175 4.9 97.4 1.0
C B:TYR175 4.9 0.8 1.0
O A:TYR175 4.9 98.4 1.0
O B:TYR175 5.0 0.1 1.0
O A:THR281 5.0 93.5 1.0

Potassium binding site 3 out of 8 in 4bw5

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Potassium binding site 3 out of 8 in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1)


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K602

b:93.2
occ:1.00
 O A:THR281 2.4 93.5 1.0
O A:ILE173 2.5 91.3 1.0
O B:THR281 2.5 92.0 1.0
O B:ILE173 2.7 99.3 1.0
O A:THR172 2.7 92.6 1.0
O B:VAL282 2.7 89.8 1.0
O A:VAL282 2.8 92.8 1.0
O B:THR172 2.8 98.1 1.0
K A:K601 3.1 98.0 1.0
C A:ILE173 3.3 91.6 1.0
K A:K603 3.4 0.3 1.0
C B:ILE173 3.5 0.3 1.0
C A:VAL282 3.5 95.1 1.0
C B:VAL282 3.5 90.3 1.0
C A:THR281 3.6 95.9 1.0
C B:THR281 3.7 91.3 1.0
C A:THR172 3.8 92.9 1.0
CA A:ILE173 3.9 88.1 1.0
C B:THR172 3.9 0.7 1.0
CA A:VAL282 4.0 92.6 1.0
CA B:VAL282 4.0 85.4 1.0
CA B:ILE173 4.0 96.0 1.0
N A:VAL282 4.2 93.5 1.0
N A:GLY174 4.2 88.3 1.0
N A:ILE173 4.3 88.5 1.0
N B:VAL282 4.3 86.7 1.0
N B:GLY174 4.4 98.5 1.0
N B:ILE173 4.4 97.8 1.0
N A:GLY283 4.5 93.4 1.0
N B:GLY283 4.5 88.1 1.0
CA A:GLY174 4.7 87.5 1.0
O A:GLY174 4.7 91.1 1.0
O B:GLY174 4.7 0.5 1.0
CA B:GLY174 4.7 98.6 1.0
CA A:THR281 4.8 94.4 1.0
O A:GLY283 4.8 94.5 1.0
CA B:THR281 4.9 87.5 1.0
O B:GLY283 4.9 94.9 1.0
CA A:GLY283 4.9 93.2 1.0
C A:GLY174 5.0 92.1 1.0
CB A:THR281 5.0 98.2 1.0
CA B:GLY283 5.0 89.1 1.0

Potassium binding site 4 out of 8 in 4bw5

Go back to Potassium Binding Sites List in 4bw5
Potassium binding site 4 out of 8 in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1)


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K603

b:0.3
occ:1.00
 OG1 A:THR281 2.5 97.5 1.0
O B:THR172 2.7 98.1 1.0
OG1 B:THR281 2.7 85.9 1.0
OG1 B:THR172 2.7 93.3 1.0
O A:THR281 2.8 93.5 1.0
O B:THR281 2.9 92.0 1.0
O A:THR172 2.9 92.6 1.0
OG1 A:THR172 3.0 91.2 1.0
CB A:THR281 3.2 98.2 1.0
CB B:THR281 3.3 88.4 1.0
CB B:THR172 3.4 0.4 1.0
K A:K602 3.4 93.2 1.0
C B:THR172 3.6 0.7 1.0
C A:THR281 3.6 95.9 1.0
CB A:THR172 3.7 92.8 1.0
C B:THR281 3.7 91.3 1.0
C A:THR172 3.9 92.9 1.0
CA A:THR281 4.0 94.4 1.0
CA B:THR172 4.1 99.2 1.0
CA B:THR281 4.1 87.5 1.0
CG2 B:THR281 4.4 84.7 1.0
CA A:THR172 4.5 90.2 1.0
CG2 A:THR281 4.5 96.6 1.0
N B:ILE173 4.6 97.8 1.0
CG2 B:THR172 4.6 0.5 1.0
N A:VAL282 4.6 93.5 1.0
O A:THR280 4.8 0.0 1.0
N B:VAL282 4.8 86.7 1.0
N A:ILE173 4.8 88.5 1.0
O B:THR280 5.0 92.3 1.0
CG2 A:THR172 5.0 89.7 1.0
CA B:ILE173 5.0 96.0 1.0
O B:THR171 5.0 0.5 1.0

Potassium binding site 5 out of 8 in 4bw5

Go back to Potassium Binding Sites List in 4bw5
Potassium binding site 5 out of 8 in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1)


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K600

b:0.0
occ:1.00
 O D:TYR175 2.5 0.6 1.0
O C:TYR175 2.6 0.2 1.0
O C:PHE284 2.8 0.2 1.0
O D:PHE284 2.8 0.6 1.0
O C:GLY174 3.0 0.7 1.0
O D:GLY174 3.1 0.6 1.0
O D:GLY283 3.1 0.7 1.0
O C:GLY283 3.1 0.5 1.0
C C:TYR175 3.2 0.7 1.0
C D:TYR175 3.3 0.4 1.0
K C:K601 3.3 0.7 1.0
C D:PHE284 3.4 0.1 1.0
C C:PHE284 3.5 0.3 1.0
N C:GLY176 3.9 0.7 1.0
CA D:PHE284 3.9 0.7 1.0
CA C:PHE284 3.9 0.8 1.0
N D:GLY176 4.0 0.1 1.0
CA C:GLY176 4.0 0.7 1.0
CA C:TYR175 4.0 0.3 1.0
CA D:TYR175 4.1 0.9 1.0
CA D:GLY176 4.1 0.4 1.0
C C:GLY174 4.1 0.4 1.0
C D:GLY283 4.1 0.2 1.0
C D:GLY174 4.1 0.7 1.0
C C:GLY283 4.1 0.4 1.0
N C:GLY285 4.4 0.7 1.0
N D:GLY285 4.4 0.9 1.0
N D:PHE284 4.5 0.6 1.0
N C:PHE284 4.5 0.2 1.0
N C:TYR175 4.5 0.0 1.0
N D:TYR175 4.6 0.4 1.0
CA C:GLY285 4.8 0.2 1.0
CA D:GLY285 4.8 0.3 1.0
C C:GLY176 4.9 0.6 1.0
C D:GLY176 5.0 0.6 1.0

Potassium binding site 6 out of 8 in 4bw5

Go back to Potassium Binding Sites List in 4bw5
Potassium binding site 6 out of 8 in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1)


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 6 of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K601

b:0.7
occ:1.00
 O C:GLY174 2.3 0.7 1.0
O D:GLY174 2.4 0.6 1.0
O C:GLY283 2.5 0.5 1.0
O D:GLY283 2.6 0.7 1.0
O D:VAL282 2.7 0.4 1.0
O C:VAL282 2.7 0.1 1.0
O C:ILE173 2.8 0.4 1.0
O D:ILE173 2.9 0.1 1.0
K C:K602 3.2 0.8 1.0
C C:GLY174 3.2 0.4 1.0
K C:K600 3.3 0.0 1.0
C D:GLY174 3.4 0.7 1.0
C C:GLY283 3.4 0.4 1.0
C D:GLY283 3.5 0.2 1.0
CA C:GLY174 3.9 0.6 1.0
C C:ILE173 3.9 0.7 1.0
C C:VAL282 3.9 0.0 1.0
C D:VAL282 3.9 0.1 1.0
CA D:GLY174 4.0 0.3 1.0
C D:ILE173 4.0 0.9 1.0
CA C:GLY283 4.0 0.3 1.0
CA D:GLY283 4.1 0.8 1.0
N C:TYR175 4.2 0.0 1.0
N C:GLY174 4.3 0.8 1.0
N D:TYR175 4.4 0.4 1.0
N C:GLY283 4.4 0.6 1.0
N D:GLY174 4.4 0.1 1.0
N D:GLY283 4.4 1.0 1.0
N C:PHE284 4.4 0.2 1.0
N D:PHE284 4.5 0.6 1.0
CA C:TYR175 4.6 0.3 1.0
CA D:TYR175 4.8 0.9 1.0
CA C:PHE284 4.8 0.8 1.0
C C:TYR175 4.8 0.7 1.0
CA D:PHE284 4.8 0.7 1.0
O D:TYR175 4.9 0.6 1.0
O C:TYR175 4.9 0.2 1.0
C D:TYR175 4.9 0.4 1.0
O C:THR281 5.0 0.4 1.0

Potassium binding site 7 out of 8 in 4bw5

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Potassium binding site 7 out of 8 in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1)


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 7 of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K602

b:0.8
occ:1.00
 O C:THR281 2.4 0.4 1.0
O D:THR281 2.5 0.3 1.0
O C:ILE173 2.6 0.4 1.0
O C:THR172 2.7 0.1 1.0
O C:VAL282 2.7 0.1 1.0
O D:ILE173 2.7 0.1 1.0
O D:VAL282 2.8 0.4 1.0
O D:THR172 2.8 0.4 1.0
K C:K601 3.2 0.7 1.0
C C:ILE173 3.3 0.7 1.0
K C:K603 3.4 0.5 1.0
C C:VAL282 3.5 0.0 1.0
C D:ILE173 3.5 0.9 1.0
C D:VAL282 3.5 0.1 1.0
C C:THR281 3.6 1.0 1.0
C D:THR281 3.7 0.6 1.0
C C:THR172 3.8 0.7 1.0
CA C:ILE173 3.9 0.9 1.0
C D:THR172 3.9 0.8 1.0
CA D:VAL282 4.0 0.3 1.0
CA C:VAL282 4.0 0.6 1.0
CA D:ILE173 4.1 0.5 1.0
N C:VAL282 4.2 0.8 1.0
N C:GLY174 4.2 0.8 1.0
N D:VAL282 4.3 0.3 1.0
N C:ILE173 4.3 0.9 1.0
N D:GLY174 4.4 0.1 1.0
N C:GLY283 4.5 0.6 1.0
N D:ILE173 4.5 0.8 1.0
N D:GLY283 4.5 1.0 1.0
CA C:GLY174 4.7 0.6 1.0
O C:GLY174 4.7 0.7 1.0
CA C:THR281 4.8 0.6 1.0
CA D:GLY174 4.8 0.3 1.0
O D:GLY174 4.8 0.6 1.0
O C:GLY283 4.9 0.5 1.0
CA D:THR281 4.9 0.4 1.0
CA C:GLY283 4.9 0.3 1.0
O D:GLY283 4.9 0.7 1.0
CB C:THR281 5.0 0.8 1.0
C C:GLY174 5.0 0.4 1.0
OG1 C:THR281 5.0 0.7 1.0

Potassium binding site 8 out of 8 in 4bw5

Go back to Potassium Binding Sites List in 4bw5
Potassium binding site 8 out of 8 in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1)


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 8 of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K603

b:0.5
occ:1.00
 OG1 C:THR281 2.6 0.7 1.0
OG1 D:THR281 2.6 0.1 1.0
O D:THR172 2.7 0.4 1.0
OG1 D:THR172 2.8 0.4 1.0
O C:THR281 2.8 0.4 1.0
O D:THR281 2.8 0.3 1.0
O C:THR172 2.9 0.1 1.0
OG1 C:THR172 3.0 0.3 1.0
CB D:THR281 3.2 0.2 1.0
CB C:THR281 3.3 0.8 1.0
K C:K602 3.4 0.8 1.0
CB D:THR172 3.5 0.7 1.0
C D:THR172 3.6 0.8 1.0
C C:THR281 3.6 1.0 1.0
C D:THR281 3.7 0.6 1.0
CB C:THR172 3.7 0.4 1.0
C C:THR172 3.8 0.7 1.0
CA D:THR281 4.0 0.4 1.0
CA C:THR281 4.1 0.6 1.0
CA D:THR172 4.2 1.0 1.0
CG2 D:THR281 4.4 0.6 1.0
CA C:THR172 4.4 0.3 1.0
CG2 C:THR281 4.5 0.1 1.0
N D:ILE173 4.6 0.8 1.0
N C:VAL282 4.6 0.8 1.0
CG2 D:THR172 4.7 0.7 1.0
N D:VAL282 4.7 0.3 1.0
O C:THR280 4.8 0.6 1.0
N C:ILE173 4.8 0.9 1.0
O D:THR280 4.9 0.4 1.0
CG2 C:THR172 4.9 0.1 1.0
CA D:ILE173 5.0 0.5 1.0

Reference:

A.C.W.Pike, A.Mackenzie, C.Mcclenaghan, P.Aryal, L.Dong, A.Quigley, M.Grieben, S.Goubin, S.Mukhopadhyay, G.F.Ruda, M.V.Clausen, L.Cao, P.E.Brennan, N.A.Burgess-Brown, M.S.P.Sansom, S.J.Tucker, E.P.Carpenter. K2P Channel Gating Mechanisms Revealed By Structures of Trek-2 and A Complex with Prozac Science V. 347 1256 2015.
ISSN: ISSN 0036-8075
PubMed: 25766236
DOI: 10.1126/SCIENCE.1261512
Page generated: Mon Aug 12 10:13:12 2024

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