Potassium in PDB 1k8p: Structure of the Human G-Quadruplex Reveals A Novel Topology

The structure of Structure of the Human G-Quadruplex Reveals A Novel Topology, PDB code: 1k8p was solved by G.N.Parkinson, M.P.H.Lee, S.Neidle, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	10.00 / 2.40
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	56.607, 56.607, 40.546, 90.00, 90.00, 120.00
R / Rfree (%)	19.3 / 28

The structure of Structure of the Human G-Quadruplex Reveals A Novel Topology also contains other interesting chemical elements:

Bromine	(Br)	4 atoms
Sodium	(Na)	1 atom

The binding sites of Potassium atom in the Structure of the Human G-Quadruplex Reveals A Novel Topology (pdb code 1k8p). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Structure of the Human G-Quadruplex Reveals A Novel Topology, PDB code: 1k8p:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the Structure of the Human G-Quadruplex Reveals A Novel Topology


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Structure of the Human G-Quadruplex Reveals A Novel Topology within 5.0Å range: probe atom residue distance (Å) B Occ A:K25 b:43.7 occ:1.00 O6 A:DG5 2.4 30.4 1.0 O6 A:DG11 2.5 47.6 1.0 O6 A:DG4 2.6 42.9 1.0 O6 B:DG17 2.7 61.1 1.0 O6 A:DG10 2.8 39.5 1.0 O6 B:DG23 2.8 46.0 1.0 O6 B:DG22 2.9 51.8 1.0 O6 B:DG16 3.0 61.6 1.0 C6 A:DG5 3.4 44.0 1.0 K A:K26 3.5 42.1 1.0 C6 A:DG4 3.5 42.9 1.0 C6 A:DG11 3.5 40.5 1.0 C6 B:DG22 3.6 50.4 1.0 C6 A:DG10 3.6 35.3 1.0 C6 B:DG23 3.7 50.3 1.0 C6 B:DG17 3.7 60.0 1.0 N1 B:DG22 3.7 43.3 1.0 C6 B:DG16 3.8 55.6 1.0 N1 A:DG5 3.8 40.8 1.0 N1 B:DG23 3.8 44.7 1.0 N1 A:DG4 3.8 43.3 1.0 N1 A:DG11 3.8 42.1 1.0 N1 A:DG10 3.9 35.0 1.0 N1 B:DG17 3.9 57.2 1.0 N1 B:DG16 4.1 54.5 1.0 C5 A:DG4 4.7 47.6 1.0 C5 A:DG5 4.8 38.5 1.0 C5 B:DG22 4.8 55.2 1.0 C5 A:DG10 4.8 30.4 1.0 C5 A:DG11 4.9 41.7 1.0 C5 B:DG16 4.9 52.0 1.0 C2 B:DG22 5.0 45.4 1.0

Potassium binding site 2 out of 2 in the Structure of the Human G-Quadruplex Reveals A Novel Topology


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Structure of the Human G-Quadruplex Reveals A Novel Topology within 5.0Å range: probe atom residue distance (Å) B Occ A:K26 b:42.1 occ:1.00 O6 B:DG16 2.6 61.6 1.0 O6 A:DG9 2.7 34.3 1.0 O6 A:DG3 2.8 49.4 1.0 O6 A:DG4 2.8 42.9 1.0 O6 A:DG10 2.9 39.5 1.0 O6 B:DG21 2.9 50.7 1.0 O6 B:DG22 2.9 51.8 1.0 O6 B:DG15 2.9 35.5 1.0 K A:K25 3.5 43.7 1.0 C6 A:DG9 3.5 35.7 1.0 C6 A:DG3 3.6 45.0 1.0 C6 B:DG16 3.6 55.6 1.0 C6 A:DG4 3.7 42.9 1.0 C6 A:DG10 3.7 35.3 1.0 C6 B:DG22 3.7 50.4 1.0 C6 B:DG21 3.8 51.1 1.0 N1 A:DG3 3.8 35.4 1.0 C6 B:DG15 3.8 45.2 1.0 N1 A:DG9 3.8 42.5 1.0 N1 A:DG4 3.9 43.3 1.0 N1 B:DG21 3.9 53.1 1.0 N1 A:DG10 4.0 35.0 1.0 N1 B:DG22 4.0 43.3 1.0 N1 B:DG16 4.0 54.5 1.0 N1 B:DG15 4.2 41.1 1.0 C5 A:DG3 4.8 42.7 1.0 C5 A:DG9 4.8 32.5 1.0 C5 A:DG4 4.8 47.6 1.0 C5 B:DG16 4.8 52.0 1.0 C5 B:DG15 4.9 46.1 1.0 C5 A:DG10 4.9 30.4 1.0 C5 B:DG22 5.0 55.2 1.0 C2 A:DG3 5.0 41.4 1.0

G.N.Parkinson, M.P.Lee, S.Neidle. Crystal Structure of Parallel Quadruplexes From Human Telomeric Dna. Nature V. 417 876 2002.
ISSN: ISSN 0028-0836
PubMed: 12050675
DOI: 10.1038/NATURE755