Potassium in PDB 9e4v: The Structure of Human Vacuolar Protein Sorting 34 Catalytic Domain Bound to Mes

All present enzymatic activity of The Structure of Human Vacuolar Protein Sorting 34 Catalytic Domain Bound to Mes:
2.7.1.137;

The structure of The Structure of Human Vacuolar Protein Sorting 34 Catalytic Domain Bound to Mes, PDB code: 9e4v was solved by W.O.Abiodun, A.Fullmer, E.Tsubaki, T.Doukov, J.D.Moody, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	61.31 / 2.36
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	114.088, 114.088, 145.397, 90, 90, 90
R / Rfree (%)	19.9 / 23.1

The structure of The Structure of Human Vacuolar Protein Sorting 34 Catalytic Domain Bound to Mes also contains other interesting chemical elements:

Chlorine

(Cl)

4 atoms

The binding sites of Potassium atom in the The Structure of Human Vacuolar Protein Sorting 34 Catalytic Domain Bound to Mes (pdb code 9e4v). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 3 binding sites of Potassium where determined in the The Structure of Human Vacuolar Protein Sorting 34 Catalytic Domain Bound to Mes, PDB code: 9e4v:
Jump to Potassium binding site number: 1; 2; 3;

Potassium binding site 1 out of 3 in the The Structure of Human Vacuolar Protein Sorting 34 Catalytic Domain Bound to Mes


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of The Structure of Human Vacuolar Protein Sorting 34 Catalytic Domain Bound to Mes within 5.0Å range: probe atom residue distance (Å) B Occ B:K913 b:83.2 occ:1.00 OH B:TYR496 4.2 51.3 1.0 O B:HOH1020 4.2 47.8 1.0 CZ B:TYR492 4.3 44.8 1.0 CG B:LEU393 4.3 56.3 1.0 CE2 B:TYR492 4.4 38.1 1.0 O B:HOH1039 4.4 50.3 1.0 O B:LEU393 4.5 44.6 1.0 CE1 B:TYR492 4.5 36.6 1.0 OH B:TYR492 4.5 46.0 1.0 CD2 B:LEU393 4.6 61.1 1.0 CD1 B:LEU393 4.7 52.0 1.0 CD2 B:TYR492 4.8 38.5 1.0 CD1 B:TYR492 4.8 41.5 1.0 SD B:MET394 4.8 80.8 1.0 CG B:TYR492 5.0 43.9 1.0 O B:HOH1057 5.0 52.9 1.0

Potassium binding site 2 out of 3 in the The Structure of Human Vacuolar Protein Sorting 34 Catalytic Domain Bound to Mes


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of The Structure of Human Vacuolar Protein Sorting 34 Catalytic Domain Bound to Mes within 5.0Å range: probe atom residue distance (Å) B Occ B:K914 b:88.5 occ:1.00 O B:SER487 4.0 47.3 1.0 CD2 B:LEU542 4.2 43.3 1.0 CB B:LEU541 4.2 53.1 1.0 CG B:PRO592 4.3 48.9 1.0 CB B:SER487 4.3 51.9 1.0 O B:MET538 4.3 47.9 1.0 CG B:LEU542 4.4 50.4 1.0 CG B:MET538 4.6 69.5 1.0 CB B:MET538 4.7 59.4 1.0 CA B:MET538 4.7 57.9 1.0 CD1 B:LEU541 4.7 52.8 1.0 CB B:ASN491 4.7 43.7 1.0 C B:SER487 4.7 47.6 1.0 CA B:SER487 4.8 52.1 1.0 N B:ASN491 4.8 38.5 1.0 N B:LEU542 4.9 48.8 1.0 CA B:ASN491 4.9 40.8 1.0 CB B:PRO592 4.9 52.8 1.0 C B:MET538 5.0 57.0 1.0

Potassium binding site 3 out of 3 in the The Structure of Human Vacuolar Protein Sorting 34 Catalytic Domain Bound to Mes


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of The Structure of Human Vacuolar Protein Sorting 34 Catalytic Domain Bound to Mes within 5.0Å range: probe atom residue distance (Å) B Occ B:K915 b:93.0 occ:1.00 O B:PRO669 4.3 44.1 1.0 CG2 B:THR668 4.4 38.2 1.0 CD B:PRO669 4.4 47.8 1.0 OE1 B:GLN683 4.4 44.3 1.0 C B:PRO669 4.5 46.8 1.0 N B:PRO669 4.5 40.1 1.0 CD1 B:ILE685 4.5 44.1 1.0 NE2 B:GLN683 4.5 44.2 1.0 CA B:THR668 4.6 42.7 1.0 C B:THR668 4.6 46.4 1.0 N B:TYR670 4.6 40.7 1.0 CA B:TYR670 4.7 43.3 1.0 CD B:GLN683 4.8 47.5 1.0 CG B:PRO669 4.9 45.1 1.0 CB B:THR668 5.0 44.3 1.0

W.O.Abiodun, R.Dass, A.Fullmer, J.D.Singleton, E.Tsubaki, J.Cartwright, C.Litchfield, T.Doukov, M.A.Peterson, J.D.Moody. Facile Bacterial Production of Human Vacuolar Protein Sorting 34 Enables Structural Characterization of Novel Inhibitors To Be Published.