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Potassium in PDB 9dwn: HTHIK1 Cryo-Em Structure in Gdn Detergent

Potassium Binding Sites:

The binding sites of Potassium atom in the HTHIK1 Cryo-Em Structure in Gdn Detergent (pdb code 9dwn). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 5 binding sites of Potassium where determined in the HTHIK1 Cryo-Em Structure in Gdn Detergent, PDB code: 9dwn:
Jump to Potassium binding site number: 1; 2; 3; 4; 5;

Potassium binding site 1 out of 5 in 9dwn

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Potassium binding site 1 out of 5 in the HTHIK1 Cryo-Em Structure in Gdn Detergent


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of HTHIK1 Cryo-Em Structure in Gdn Detergent within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K403

b:22.0
occ:1.00
 O B:GLY239 2.3 12.1 1.0
O A:GLY239 2.3 17.1 1.0
O A:GLY112 2.4 20.1 1.0
O B:GLY112 2.4 12.8 1.0
K B:K404 2.7 22.0 1.0
O A:ILE238 3.1 22.0 1.0
O B:ILE238 3.2 13.1 1.0
O A:ILE111 3.2 16.0 1.0
O B:ILE111 3.2 11.7 1.0
C B:GLY239 3.3 12.1 1.0
C A:GLY239 3.3 17.1 1.0
C A:GLY112 3.4 20.1 1.0
K A:K404 3.5 11.3 1.0
C B:GLY112 3.5 12.8 1.0
CA B:GLY239 3.9 12.1 1.0
CA A:GLY239 3.9 17.1 1.0
C A:ILE238 4.2 22.0 1.0
C B:ILE238 4.2 13.1 1.0
CA A:GLY112 4.2 20.1 1.0
CA B:GLY112 4.2 12.8 1.0
N B:PHE240 4.3 14.6 1.0
N A:PHE240 4.3 15.9 1.0
C A:ILE111 4.3 16.0 1.0
C B:ILE111 4.3 11.7 1.0
N A:PHE113 4.4 17.9 1.0
N B:PHE113 4.4 16.8 1.0
CA A:PHE113 4.4 17.9 1.0
CA B:PHE113 4.5 16.8 1.0
N A:GLY239 4.5 17.1 1.0
N B:GLY239 4.5 12.1 1.0
CA A:PHE240 4.6 15.9 1.0
CA B:PHE240 4.6 14.6 1.0
C A:PHE113 4.6 17.9 1.0
C B:PHE113 4.7 16.8 1.0
O B:PHE113 4.7 16.8 1.0
N A:GLY112 4.8 20.1 1.0
O A:PHE113 4.8 17.9 1.0
N B:GLY112 4.8 12.8 1.0
C B:PHE240 4.8 14.6 1.0
C A:PHE240 4.8 15.9 1.0
O B:PHE240 4.8 14.6 1.0
O A:PHE240 4.9 15.9 1.0

Potassium binding site 2 out of 5 in 9dwn

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Potassium binding site 2 out of 5 in the HTHIK1 Cryo-Em Structure in Gdn Detergent


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of HTHIK1 Cryo-Em Structure in Gdn Detergent within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K404

b:11.3
occ:1.00
 O B:ILE238 2.6 13.1 1.0
O A:ILE111 2.7 16.0 1.0
O B:ILE111 2.7 11.7 1.0
O B:THR237 2.9 10.4 1.0
O A:ILE238 3.0 22.0 1.0
O A:THR110 3.1 14.9 1.0
O A:THR237 3.1 16.5 1.0
O B:THR110 3.1 13.0 1.0
C B:ILE238 3.3 13.1 1.0
K A:K403 3.5 22.0 1.0
C A:ILE111 3.5 16.0 1.0
C B:ILE111 3.6 11.7 1.0
C A:ILE238 3.6 22.0 1.0
K B:K403 3.8 22.0 1.0
C B:THR237 3.8 10.4 1.0
CA B:ILE238 3.8 13.1 1.0
C A:THR110 4.0 14.9 1.0
C A:THR237 4.0 16.5 1.0
CA A:ILE111 4.0 16.0 1.0
C B:THR110 4.1 13.0 1.0
CA B:ILE111 4.1 11.7 1.0
CA A:ILE238 4.1 22.0 1.0
N B:GLY239 4.2 12.1 1.0
N B:ILE238 4.3 13.1 1.0
N A:GLY112 4.4 20.1 1.0
N A:ILE111 4.4 16.0 1.0
N A:ILE238 4.5 22.0 1.0
N A:GLY239 4.5 17.1 1.0
CA B:GLY239 4.5 12.1 1.0
N B:ILE111 4.6 11.7 1.0
O A:GLY112 4.6 20.1 1.0
N B:GLY112 4.7 12.8 1.0
CA A:GLY112 4.7 20.1 1.0
O B:GLY239 4.7 12.1 1.0
CA A:GLY239 4.8 17.1 1.0
O B:GLY112 4.8 12.8 1.0
O A:GLY239 4.8 17.1 1.0
C B:GLY239 5.0 12.1 1.0
C A:GLY112 5.0 20.1 1.0

Potassium binding site 3 out of 5 in 9dwn

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Potassium binding site 3 out of 5 in the HTHIK1 Cryo-Em Structure in Gdn Detergent


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of HTHIK1 Cryo-Em Structure in Gdn Detergent within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K403

b:22.0
occ:1.00
 O A:THR237 2.6 16.5 1.0
O B:THR110 2.7 13.0 1.0
O B:THR237 2.7 10.4 1.0
O A:THR110 2.8 14.9 1.0
OG1 A:THR237 3.0 16.5 1.0
OG1 B:THR237 3.0 10.4 1.0
OG1 B:THR110 3.2 13.0 1.0
OG1 A:THR110 3.2 14.9 1.0
CB B:THR110 3.3 13.0 1.0
CB A:THR237 3.4 16.5 1.0
CB B:THR237 3.5 10.4 1.0
CB A:THR110 3.5 14.9 1.0
C A:THR237 3.7 16.5 1.0
C B:THR110 3.7 13.0 1.0
K B:K405 3.7 37.4 1.0
C B:THR237 3.7 10.4 1.0
K A:K404 3.8 11.3 1.0
C A:THR110 3.8 14.9 1.0
CA A:THR237 4.1 16.5 1.0
CA B:THR110 4.2 13.0 1.0
CA B:THR237 4.2 10.4 1.0
CA A:THR110 4.3 14.9 1.0
CG2 B:THR110 4.5 13.0 1.0
CG2 A:THR237 4.6 16.5 1.0
CG2 B:THR237 4.7 10.4 1.0
CG2 A:THR110 4.8 14.9 1.0
N B:ILE111 4.8 11.7 1.0
N A:ILE238 4.8 22.0 1.0
N B:ILE238 4.9 13.1 1.0
N A:ILE111 5.0 16.0 1.0
O B:SER109 5.0 12.0 1.0
O A:SER236 5.0 15.7 1.0

Potassium binding site 4 out of 5 in 9dwn

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Potassium binding site 4 out of 5 in the HTHIK1 Cryo-Em Structure in Gdn Detergent


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of HTHIK1 Cryo-Em Structure in Gdn Detergent within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K404

b:22.0
occ:1.00
 O B:PHE113 2.7 16.8 1.0
K A:K403 2.7 22.0 1.0
O B:GLY239 2.7 12.1 1.0
O B:PHE240 2.8 14.6 1.0
O A:PHE113 3.0 17.9 1.0
O A:GLY239 3.0 17.1 1.0
O A:PHE240 3.0 15.9 1.0
O B:GLY112 3.1 12.8 1.0
O A:GLY112 3.2 20.1 1.0
C B:PHE240 3.3 14.6 1.0
C B:PHE113 3.4 16.8 1.0
C A:PHE113 3.4 17.9 1.0
C A:PHE240 3.6 15.9 1.0
C B:GLY239 3.9 12.1 1.0
CA B:PHE240 3.9 14.6 1.0
CA B:PHE113 3.9 16.8 1.0
N A:GLY114 4.0 21.5 1.0
CA A:PHE240 4.1 15.9 1.0
CA A:PHE113 4.1 17.9 1.0
C A:GLY239 4.1 17.1 1.0
N B:GLY241 4.2 15.1 1.0
C B:GLY112 4.2 12.8 1.0
N B:GLY114 4.2 23.4 1.0
C A:GLY112 4.3 20.1 1.0
CA A:GLY114 4.4 21.5 1.0
N B:PHE240 4.4 14.6 1.0
N A:GLY241 4.5 18.8 1.0
CA B:GLY241 4.6 15.1 1.0
N B:PHE113 4.6 16.8 1.0
N A:PHE240 4.6 15.9 1.0
CA B:GLY114 4.6 23.4 1.0
N A:PHE113 4.7 17.9 1.0
CA A:GLY241 4.8 18.8 1.0

Potassium binding site 5 out of 5 in 9dwn

Go back to Potassium Binding Sites List in 9dwn
Potassium binding site 5 out of 5 in the HTHIK1 Cryo-Em Structure in Gdn Detergent


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of HTHIK1 Cryo-Em Structure in Gdn Detergent within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K405

b:37.4
occ:1.00
 CE1 B:TYR273 3.3 21.6 1.0
OG1 B:THR110 3.7 13.0 1.0
K B:K403 3.7 22.0 1.0
CE1 A:TYR273 3.7 24.3 1.0
OG1 A:THR237 3.7 16.5 1.0
OH B:TYR273 3.9 21.6 1.0
OG1 A:THR110 3.9 14.9 1.0
OG1 B:THR237 3.9 10.4 1.0
CZ B:TYR273 4.1 21.6 1.0
O B:HOH501 4.2 16.6 1.0
CD1 B:TYR273 4.2 21.6 1.0
O A:HOH501 4.3 16.2 1.0
CD1 A:ILE139 4.4 22.0 1.0
CD1 A:TYR273 4.4 24.3 1.0
CB B:THR110 4.6 13.0 1.0
CB A:THR237 4.7 16.5 1.0
CZ A:TYR273 4.7 24.3 1.0
OH A:TYR273 4.8 24.3 1.0
CB A:THR110 4.8 14.9 1.0
CB B:THR237 4.8 10.4 1.0
CG2 B:THR110 4.9 13.0 1.0
CG2 A:THR237 5.0 16.5 1.0

Reference:

E.B.Riel, W.Bu, T.T.Joseph, L.Khajoueinejad, R.G.Eckenhoff, P.M.Riegelhaupt. The Cryo-Em Structure and Physical Basis For Anesthetic Inhibition of the THIK1 K2P Channel. Proc.Natl.Acad.Sci.Usa V. 122 54122 2025.
ISSN: ESSN 1091-6490
PubMed: 40178898
DOI: 10.1073/PNAS.2421654122
Page generated: Sat Aug 9 18:49:13 2025

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