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Potassium in PDB 8vx0: Crystal Structure of CYP2C9*14 in Complex with Losartan

Enzymatic activity of Crystal Structure of CYP2C9*14 in Complex with Losartan

All present enzymatic activity of Crystal Structure of CYP2C9*14 in Complex with Losartan:
1.14.14.1; 1.14.14.51; 1.14.14.52; 1.14.14.53;

Protein crystallography data

The structure of Crystal Structure of CYP2C9*14 in Complex with Losartan, PDB code: 8vx0 was solved by M.B.Shah, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.01 / 3.05
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 75.209, 141.659, 161.879, 90, 90, 90
R / Rfree (%) 13.9 / 20.6

Other elements in 8vx0:

The structure of Crystal Structure of CYP2C9*14 in Complex with Losartan also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms
Iron (Fe) 1 atom

Potassium Binding Sites:

The binding sites of Potassium atom in the Crystal Structure of CYP2C9*14 in Complex with Losartan (pdb code 8vx0). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Crystal Structure of CYP2C9*14 in Complex with Losartan, PDB code: 8vx0:

Potassium binding site 1 out of 1 in 8vx0

Go back to Potassium Binding Sites List in 8vx0
Potassium binding site 1 out of 1 in the Crystal Structure of CYP2C9*14 in Complex with Losartan


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of CYP2C9*14 in Complex with Losartan within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K503

b:81.4
occ:1.00
N3 A:LSN502 4.1 49.3 1.0
C22 A:LSN502 4.2 83.7 1.0
CA A:GLY228 4.2 38.6 1.0
C21 A:LSN502 4.4 89.1 1.0
C13 A:LSN502 4.4 51.1 1.0
N A:GLY228 4.4 36.2 1.0
C20 A:LSN502 4.5 82.4 1.0
N4 A:LSN502 4.5 43.3 1.0
N2 A:LSN502 4.7 46.9 1.0
C14 A:LSN502 4.7 46.7 1.0

Reference:

S.J.Parikh, S.Edara, S.Deodhar, A.K.Singh, K.Maekawa, Q.Zhang, K.C.Glass, M.B.Shah. Structural and Biophysical Analysis of Cytochrome P450 2C9*14 and *27 Variants in Complex with Losartan J.Inorg.Biochem. 2024.
ISSN: ISSN 0162-0134
DOI: 10.1016/J.JINORGBIO.2024.112622
Page generated: Sat Aug 9 18:11:04 2025

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