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Potassium in PDB 8axz: Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with S-Adenosylmethionine, Adenosin and Diphosphono- Aminophosphonic Acid.

Enzymatic activity of Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with S-Adenosylmethionine, Adenosin and Diphosphono- Aminophosphonic Acid.

All present enzymatic activity of Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with S-Adenosylmethionine, Adenosin and Diphosphono- Aminophosphonic Acid.:
2.5.1.6;

Protein crystallography data

The structure of Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with S-Adenosylmethionine, Adenosin and Diphosphono- Aminophosphonic Acid., PDB code: 8axz was solved by A.Nawrotek, L.Vuillard, L.Miallau, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 58.63 / 1.15
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 67.554, 94.387, 117.266, 90, 90, 90
R / Rfree (%) 16.8 / 18.5

Other elements in 8axz:

The structure of Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with S-Adenosylmethionine, Adenosin and Diphosphono- Aminophosphonic Acid. also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with S-Adenosylmethionine, Adenosin and Diphosphono- Aminophosphonic Acid. (pdb code 8axz). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with S-Adenosylmethionine, Adenosin and Diphosphono- Aminophosphonic Acid., PDB code: 8axz:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in 8axz

Go back to Potassium Binding Sites List in 8axz
Potassium binding site 1 out of 2 in the Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with S-Adenosylmethionine, Adenosin and Diphosphono- Aminophosphonic Acid.


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with S-Adenosylmethionine, Adenosin and Diphosphono- Aminophosphonic Acid. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K404

b:14.4
occ:0.70
O2B A:PPK401 2.7 13.2 0.5
O A:ALA259 2.8 11.5 1.0
OD1 A:ASP258 2.8 15.1 0.8
O A:HOH555 3.2 12.8 1.0
O A:HOH514 3.3 13.9 1.0
CG A:ASP258 3.6 14.6 0.8
C A:ALA259 3.8 10.1 1.0
MG A:MG402 3.8 7.0 0.7
OD2 A:ASP258 3.9 15.5 0.8
N A:ALA259 4.0 9.8 1.0
PB A:PPK401 4.1 17.4 0.5
O A:HOH501 4.2 26.9 1.0
CA A:ALA259 4.2 9.7 1.0
CB A:ALA259 4.2 11.1 1.0
O1B A:PPK401 4.4 19.4 0.5
N A:SAM406 4.5 12.6 0.5
C A:ASP258 4.5 12.1 1.0
NH2 A:ARG264 4.6 12.5 1.0
CB A:ASP258 4.8 12.9 1.0
N A:GLY260 4.9 9.7 1.0
CA A:ASP258 4.9 12.0 1.0

Potassium binding site 2 out of 2 in 8axz

Go back to Potassium Binding Sites List in 8axz
Potassium binding site 2 out of 2 in the Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with S-Adenosylmethionine, Adenosin and Diphosphono- Aminophosphonic Acid.


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with S-Adenosylmethionine, Adenosin and Diphosphono- Aminophosphonic Acid. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K405

b:16.1
occ:0.60
O A:HOH653 2.8 23.1 1.0
O A:HOH701 2.8 11.8 1.0
O A:HOH723 3.0 16.6 1.0
N A:PHE139 3.0 8.3 1.0
N A:GLY278 3.0 8.2 1.0
CA A:MET138 3.5 8.4 1.0
ND1 A:HIS277 3.6 9.4 1.0
C A:MET138 3.7 8.1 1.0
CE1 A:HIS277 3.7 9.6 1.0
CA A:HIS277 3.8 9.1 1.0
O A:PHE139 3.8 9.0 1.0
CG A:HIS277 3.9 9.1 1.0
C A:HIS277 3.9 8.3 1.0
CA A:GLY278 3.9 9.0 1.0
CB A:MET138 4.0 8.2 1.0
CA A:PHE139 4.1 8.6 1.0
NE2 A:HIS277 4.1 10.0 1.0
CD2 A:HIS277 4.2 9.5 1.0
CD1 A:PHE139 4.3 8.4 1.0
CB A:PHE139 4.3 8.5 1.0
O A:HOH625 4.4 16.5 1.0
C A:PHE139 4.4 8.2 1.0
O A:LEU137 4.4 7.8 1.0
CB A:HIS277 4.5 9.2 1.0
O A:ALA276 4.6 10.0 1.0
CB A:ALA295 4.6 9.8 1.0
N A:MET138 4.6 7.8 1.0
N A:GLY279 4.7 8.7 1.0
CG A:MET138 4.7 9.1 1.0
C A:GLY278 4.7 9.1 1.0
CG A:PHE139 4.8 8.5 1.0
N A:HIS277 4.9 9.3 1.0
O A:MET138 4.9 8.7 1.0
C A:LEU137 5.0 7.3 1.0

Reference:

A.Nawrotek, L.Vuillard, L.Miallau. Crystal Structure of Human Methionine Adenosyltransferase 2A (MAT2A) in Complex with S-Adenosylmethionine, Adenosin and Diphosphono-Aminophosphonic Acid. To Be Published.
Page generated: Sat Aug 9 15:34:25 2025

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