Potassium in PDB 7xnk: Human KCNQ1-Cam in Complex with ML277
Potassium Binding Sites:
The binding sites of Potassium atom in the Human KCNQ1-Cam in Complex with ML277
(pdb code 7xnk). This binding sites where shown within
5.0 Angstroms radius around Potassium atom.
In total 4 binding sites of Potassium where determined in the
Human KCNQ1-Cam in Complex with ML277, PDB code: 7xnk:
Jump to Potassium binding site number:
1;
2;
3;
4;
Potassium binding site 1 out
of 4 in 7xnk
Go back to
Potassium Binding Sites List in 7xnk
Potassium binding site 1 out
of 4 in the Human KCNQ1-Cam in Complex with ML277
 Mono view
 Stereo pair view
|
|
A full contact list of Potassium with other atoms in the K binding
site number 1 of Human KCNQ1-Cam in Complex with ML277 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K701
b:49.1
occ:1.00
|
O
|
C:GLY314
|
2.9
|
38.8
|
1.0
|
|
O
|
A:GLY314
|
2.9
|
38.8
|
1.0
|
|
O
|
E:GLY314
|
3.0
|
38.6
|
1.0
|
|
O
|
A:TYR315
|
3.0
|
40.8
|
1.0
|
|
O
|
G:GLY314
|
3.0
|
38.7
|
1.0
|
|
O
|
E:TYR315
|
3.0
|
40.6
|
1.0
|
|
O
|
C:TYR315
|
3.0
|
40.5
|
1.0
|
|
O
|
G:TYR315
|
3.1
|
40.8
|
1.0
|
|
K
|
A:K702
|
3.5
|
31.4
|
1.0
|
|
C
|
A:TYR315
|
3.6
|
40.8
|
1.0
|
|
C
|
C:TYR315
|
3.6
|
40.5
|
1.0
|
|
HA
|
A:TYR315
|
3.6
|
40.8
|
1.0
|
|
C
|
E:TYR315
|
3.6
|
40.6
|
1.0
|
|
HA
|
E:TYR315
|
3.6
|
40.6
|
1.0
|
|
HA
|
C:TYR315
|
3.6
|
40.5
|
1.0
|
|
HA
|
G:TYR315
|
3.7
|
40.8
|
1.0
|
|
C
|
G:TYR315
|
3.7
|
40.8
|
1.0
|
|
C
|
C:GLY314
|
4.0
|
38.8
|
1.0
|
|
C
|
A:GLY314
|
4.0
|
38.8
|
1.0
|
|
CA
|
A:TYR315
|
4.1
|
40.8
|
1.0
|
|
CA
|
C:TYR315
|
4.1
|
40.5
|
1.0
|
|
HA3
|
A:GLY316
|
4.1
|
43.9
|
1.0
|
|
C
|
E:GLY314
|
4.1
|
38.6
|
1.0
|
|
HA3
|
C:GLY316
|
4.1
|
43.5
|
1.0
|
|
CA
|
E:TYR315
|
4.1
|
40.6
|
1.0
|
|
C
|
G:GLY314
|
4.1
|
38.7
|
1.0
|
|
HA3
|
E:GLY316
|
4.2
|
43.5
|
1.0
|
|
CA
|
G:TYR315
|
4.2
|
40.8
|
1.0
|
|
HA3
|
G:GLY316
|
4.2
|
43.7
|
1.0
|
|
N
|
A:GLY316
|
4.3
|
43.9
|
1.0
|
|
N
|
C:GLY316
|
4.3
|
43.5
|
1.0
|
|
N
|
E:GLY316
|
4.4
|
43.5
|
1.0
|
|
N
|
G:GLY316
|
4.5
|
43.7
|
1.0
|
|
N
|
A:TYR315
|
4.6
|
40.8
|
1.0
|
|
N
|
C:TYR315
|
4.6
|
40.5
|
1.0
|
|
N
|
E:TYR315
|
4.6
|
40.6
|
1.0
|
|
N
|
G:TYR315
|
4.7
|
40.8
|
1.0
|
|
CA
|
A:GLY316
|
4.7
|
43.9
|
1.0
|
|
CA
|
C:GLY316
|
4.7
|
43.5
|
1.0
|
|
CA
|
E:GLY316
|
4.8
|
43.5
|
1.0
|
|
CA
|
G:GLY316
|
4.9
|
43.7
|
1.0
|
|
H
|
C:GLY316
|
4.9
|
43.5
|
1.0
|
|
H
|
A:GLY316
|
4.9
|
43.9
|
1.0
|
|
H
|
E:GLY316
|
5.0
|
43.5
|
1.0
|
|
Potassium binding site 2 out
of 4 in 7xnk
Go back to
Potassium Binding Sites List in 7xnk
Potassium binding site 2 out
of 4 in the Human KCNQ1-Cam in Complex with ML277
 Mono view
 Stereo pair view
|
|
A full contact list of Potassium with other atoms in the K binding
site number 2 of Human KCNQ1-Cam in Complex with ML277 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K702
b:31.4
occ:1.00
|
O
|
A:GLY314
|
2.6
|
38.8
|
1.0
|
|
O
|
E:ILE313
|
2.7
|
38.6
|
1.0
|
|
O
|
E:GLY314
|
2.7
|
38.6
|
1.0
|
|
O
|
A:ILE313
|
2.7
|
39.1
|
1.0
|
|
O
|
C:ILE313
|
2.7
|
38.8
|
1.0
|
|
O
|
G:ILE313
|
2.7
|
38.9
|
1.0
|
|
O
|
C:GLY314
|
2.7
|
38.8
|
1.0
|
|
O
|
G:GLY314
|
2.7
|
38.7
|
1.0
|
|
HA3
|
A:GLY314
|
3.4
|
38.8
|
1.0
|
|
C
|
A:GLY314
|
3.4
|
38.8
|
1.0
|
|
K
|
A:K701
|
3.5
|
49.1
|
1.0
|
|
HA3
|
C:GLY314
|
3.5
|
38.8
|
1.0
|
|
C
|
E:GLY314
|
3.5
|
38.6
|
1.0
|
|
HA3
|
G:GLY314
|
3.5
|
38.7
|
1.0
|
|
C
|
C:GLY314
|
3.5
|
38.8
|
1.0
|
|
HA3
|
E:GLY314
|
3.5
|
38.6
|
1.0
|
|
C
|
G:GLY314
|
3.5
|
38.7
|
1.0
|
|
K
|
A:K703
|
3.5
|
29.5
|
1.0
|
|
C
|
A:ILE313
|
3.8
|
39.1
|
1.0
|
|
C
|
E:ILE313
|
3.8
|
38.6
|
1.0
|
|
C
|
C:ILE313
|
3.8
|
38.8
|
1.0
|
|
C
|
G:ILE313
|
3.8
|
38.9
|
1.0
|
|
CA
|
A:GLY314
|
3.8
|
38.8
|
1.0
|
|
CA
|
C:GLY314
|
3.9
|
38.8
|
1.0
|
|
CA
|
E:GLY314
|
3.9
|
38.6
|
1.0
|
|
CA
|
G:GLY314
|
3.9
|
38.7
|
1.0
|
|
N
|
A:GLY314
|
4.3
|
38.8
|
1.0
|
|
N
|
C:GLY314
|
4.3
|
38.8
|
1.0
|
|
N
|
E:GLY314
|
4.3
|
38.6
|
1.0
|
|
N
|
G:GLY314
|
4.3
|
38.7
|
1.0
|
|
HA
|
E:TYR315
|
4.4
|
40.6
|
1.0
|
|
HA
|
A:TYR315
|
4.5
|
40.8
|
1.0
|
|
HA
|
G:TYR315
|
4.5
|
40.8
|
1.0
|
|
N
|
E:TYR315
|
4.5
|
40.6
|
1.0
|
|
N
|
A:TYR315
|
4.5
|
40.8
|
1.0
|
|
HA
|
C:TYR315
|
4.5
|
40.5
|
1.0
|
|
N
|
C:TYR315
|
4.6
|
40.5
|
1.0
|
|
N
|
G:TYR315
|
4.6
|
40.8
|
1.0
|
|
HA2
|
A:GLY314
|
4.7
|
38.8
|
1.0
|
|
HA2
|
C:GLY314
|
4.8
|
38.8
|
1.0
|
|
HA2
|
E:GLY314
|
4.8
|
38.6
|
1.0
|
|
HA2
|
G:GLY314
|
4.8
|
38.7
|
1.0
|
|
HA
|
E:ILE313
|
4.9
|
38.6
|
1.0
|
|
CA
|
E:TYR315
|
4.9
|
40.6
|
1.0
|
|
HA
|
C:ILE313
|
4.9
|
38.8
|
1.0
|
|
HA
|
G:ILE313
|
4.9
|
38.9
|
1.0
|
|
HA
|
A:ILE313
|
4.9
|
39.1
|
1.0
|
|
CA
|
A:TYR315
|
5.0
|
40.8
|
1.0
|
|
CA
|
G:TYR315
|
5.0
|
40.8
|
1.0
|
|
Potassium binding site 3 out
of 4 in 7xnk
Go back to
Potassium Binding Sites List in 7xnk
Potassium binding site 3 out
of 4 in the Human KCNQ1-Cam in Complex with ML277
 Mono view
 Stereo pair view
|
|
A full contact list of Potassium with other atoms in the K binding
site number 3 of Human KCNQ1-Cam in Complex with ML277 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K703
b:29.5
occ:1.00
|
O
|
C:THR312
|
2.8
|
40.0
|
1.0
|
|
O
|
A:THR312
|
2.8
|
40.1
|
1.0
|
|
O
|
E:THR312
|
2.9
|
39.8
|
1.0
|
|
O
|
G:THR312
|
2.9
|
40.1
|
1.0
|
|
O
|
E:ILE313
|
3.0
|
38.6
|
1.0
|
|
O
|
A:ILE313
|
3.0
|
39.1
|
1.0
|
|
O
|
C:ILE313
|
3.0
|
38.8
|
1.0
|
|
O
|
G:ILE313
|
3.1
|
38.9
|
1.0
|
|
K
|
A:K704
|
3.3
|
37.8
|
1.0
|
|
HA
|
E:ILE313
|
3.4
|
38.6
|
1.0
|
|
HA
|
A:ILE313
|
3.4
|
39.1
|
1.0
|
|
HA
|
C:ILE313
|
3.4
|
38.8
|
1.0
|
|
HA
|
G:ILE313
|
3.4
|
38.9
|
1.0
|
|
K
|
A:K702
|
3.5
|
31.4
|
1.0
|
|
C
|
A:ILE313
|
3.6
|
39.1
|
1.0
|
|
C
|
E:ILE313
|
3.6
|
38.6
|
1.0
|
|
C
|
C:ILE313
|
3.6
|
38.8
|
1.0
|
|
C
|
G:ILE313
|
3.7
|
38.9
|
1.0
|
|
C
|
C:THR312
|
3.7
|
40.0
|
1.0
|
|
C
|
A:THR312
|
3.7
|
40.1
|
1.0
|
|
C
|
E:THR312
|
3.8
|
39.8
|
1.0
|
|
C
|
G:THR312
|
3.8
|
40.1
|
1.0
|
|
CA
|
A:ILE313
|
3.9
|
39.1
|
1.0
|
|
CA
|
E:ILE313
|
3.9
|
38.6
|
1.0
|
|
CA
|
C:ILE313
|
3.9
|
38.8
|
1.0
|
|
CA
|
G:ILE313
|
4.0
|
38.9
|
1.0
|
|
N
|
A:ILE313
|
4.2
|
39.1
|
1.0
|
|
N
|
C:ILE313
|
4.2
|
38.8
|
1.0
|
|
N
|
E:ILE313
|
4.2
|
38.6
|
1.0
|
|
HB
|
C:THR312
|
4.3
|
40.0
|
1.0
|
|
HB
|
A:THR312
|
4.3
|
40.1
|
1.0
|
|
N
|
G:ILE313
|
4.3
|
38.9
|
1.0
|
|
HB
|
E:THR312
|
4.4
|
39.8
|
1.0
|
|
HB
|
G:THR312
|
4.4
|
40.1
|
1.0
|
|
N
|
A:GLY314
|
4.6
|
38.8
|
1.0
|
|
N
|
C:GLY314
|
4.6
|
38.8
|
1.0
|
|
N
|
E:GLY314
|
4.6
|
38.6
|
1.0
|
|
HA3
|
A:GLY314
|
4.7
|
38.8
|
1.0
|
|
HA3
|
C:GLY314
|
4.7
|
38.8
|
1.0
|
|
HA3
|
E:GLY314
|
4.7
|
38.6
|
1.0
|
|
N
|
G:GLY314
|
4.7
|
38.7
|
1.0
|
|
HA3
|
G:GLY314
|
4.7
|
38.7
|
1.0
|
|
CA
|
C:THR312
|
4.8
|
40.0
|
1.0
|
|
CA
|
A:THR312
|
4.8
|
40.1
|
1.0
|
|
HA
|
C:THR312
|
4.9
|
40.0
|
1.0
|
|
HA
|
A:THR312
|
4.9
|
40.1
|
1.0
|
|
CA
|
E:THR312
|
4.9
|
39.8
|
1.0
|
|
HA
|
E:THR312
|
4.9
|
39.8
|
1.0
|
|
CA
|
G:THR312
|
4.9
|
40.1
|
1.0
|
|
H
|
A:ILE313
|
5.0
|
39.1
|
1.0
|
|
CB
|
C:THR312
|
5.0
|
40.0
|
1.0
|
|
H
|
C:ILE313
|
5.0
|
38.8
|
1.0
|
|
HA
|
G:THR312
|
5.0
|
40.1
|
1.0
|
|
CB
|
A:THR312
|
5.0
|
40.1
|
1.0
|
|
Potassium binding site 4 out
of 4 in 7xnk
Go back to
Potassium Binding Sites List in 7xnk
Potassium binding site 4 out
of 4 in the Human KCNQ1-Cam in Complex with ML277
 Mono view
 Stereo pair view
|
|
A full contact list of Potassium with other atoms in the K binding
site number 4 of Human KCNQ1-Cam in Complex with ML277 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K704
b:37.8
occ:1.00
|
HB
|
A:THR312
|
2.6
|
40.1
|
1.0
|
|
HB
|
C:THR312
|
2.7
|
40.0
|
1.0
|
|
HB
|
E:THR312
|
2.7
|
39.8
|
1.0
|
|
O
|
A:THR312
|
2.7
|
40.1
|
1.0
|
|
O
|
E:THR312
|
2.7
|
39.8
|
1.0
|
|
HB
|
G:THR312
|
2.8
|
40.1
|
1.0
|
|
O
|
C:THR312
|
2.8
|
40.0
|
1.0
|
|
O
|
G:THR312
|
2.8
|
40.1
|
1.0
|
|
K
|
A:K703
|
3.3
|
29.5
|
1.0
|
|
CB
|
A:THR312
|
3.4
|
40.1
|
1.0
|
|
OG1
|
A:THR312
|
3.4
|
40.1
|
1.0
|
|
CB
|
C:THR312
|
3.4
|
40.0
|
1.0
|
|
OG1
|
C:THR312
|
3.4
|
40.0
|
1.0
|
|
HG1
|
A:THR312
|
3.4
|
40.1
|
1.0
|
|
OG1
|
E:THR312
|
3.5
|
39.8
|
1.0
|
|
HG1
|
C:THR312
|
3.5
|
40.0
|
1.0
|
|
HG1
|
G:THR312
|
3.5
|
40.1
|
1.0
|
|
CB
|
E:THR312
|
3.5
|
39.8
|
1.0
|
|
HG1
|
E:THR312
|
3.5
|
39.8
|
1.0
|
|
OG1
|
G:THR312
|
3.5
|
40.1
|
1.0
|
|
CB
|
G:THR312
|
3.5
|
40.1
|
1.0
|
|
C
|
A:THR312
|
3.8
|
40.1
|
1.0
|
|
C
|
E:THR312
|
3.8
|
39.8
|
1.0
|
|
C
|
C:THR312
|
3.8
|
40.0
|
1.0
|
|
C
|
G:THR312
|
3.9
|
40.1
|
1.0
|
|
CA
|
A:THR312
|
4.2
|
40.1
|
1.0
|
|
CA
|
C:THR312
|
4.3
|
40.0
|
1.0
|
|
CA
|
E:THR312
|
4.3
|
39.8
|
1.0
|
|
HG21
|
A:THR312
|
4.3
|
40.1
|
1.0
|
|
CA
|
G:THR312
|
4.3
|
40.1
|
1.0
|
|
HG21
|
C:THR312
|
4.3
|
40.0
|
1.0
|
|
HG21
|
E:THR312
|
4.4
|
39.8
|
1.0
|
|
CG2
|
A:THR312
|
4.4
|
40.1
|
1.0
|
|
CG2
|
C:THR312
|
4.5
|
40.0
|
1.0
|
|
HG21
|
G:THR312
|
4.5
|
40.1
|
1.0
|
|
CG2
|
E:THR312
|
4.5
|
39.8
|
1.0
|
|
CG2
|
G:THR312
|
4.5
|
40.1
|
1.0
|
|
HA
|
A:THR312
|
4.6
|
40.1
|
1.0
|
|
HA
|
C:THR312
|
4.7
|
40.0
|
1.0
|
|
HA
|
E:ILE313
|
4.7
|
38.6
|
1.0
|
|
HA
|
E:THR312
|
4.7
|
39.8
|
1.0
|
|
HA
|
A:ILE313
|
4.7
|
39.1
|
1.0
|
|
HA
|
G:THR312
|
4.7
|
40.1
|
1.0
|
|
HA
|
G:ILE313
|
4.7
|
38.9
|
1.0
|
|
HA
|
C:ILE313
|
4.7
|
38.8
|
1.0
|
|
HG22
|
A:THR312
|
4.8
|
40.1
|
1.0
|
|
HG22
|
C:THR312
|
4.8
|
40.0
|
1.0
|
|
HG22
|
G:THR312
|
4.8
|
40.1
|
1.0
|
|
HG22
|
E:THR312
|
4.9
|
39.8
|
1.0
|
|
N
|
A:ILE313
|
5.0
|
39.1
|
1.0
|
|
N
|
E:ILE313
|
5.0
|
38.6
|
1.0
|
|
N
|
C:ILE313
|
5.0
|
38.8
|
1.0
|
|
Reference:
D.Ma,
L.Zhong,
Z.Yan,
J.Yao,
Y.Zhang,
F.Ye,
Y.Huang,
D.Lai,
W.Yang,
P.Hou,
J.Guo.
Structural Mechanisms For the Activation of Human Cardiac KCNQ1 Channel By Electro-Mechanical Coupling Enhancers Proc.Natl.Acad.Sci.Usa V. 119 2022.
ISSN: ESSN 1091-6490
DOI: 10.1073/PNAS.2207067119
Page generated: Sat Aug 9 15:14:27 2025
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