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Potassium in PDB 7sgi: Crystal Structure of Danio Rerio Histone Deacetylase 10 in Complex with Inhibitor 14
Enzymatic activity of Crystal Structure of Danio Rerio Histone Deacetylase 10 in Complex with Inhibitor 14
All present enzymatic activity of Crystal Structure of Danio Rerio Histone Deacetylase 10 in Complex with Inhibitor 14:
3.5.1.48; 3.5.1.62;
3.5.1.48; 3.5.1.62;
Protein crystallography data
The structure of Crystal Structure of Danio Rerio Histone Deacetylase 10 in Complex with Inhibitor 14, PDB code: 7sgi
was solved by
C.J.Herbst-Gervasoni,
D.W.Christianson,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 69.71 / 2.15 |
| Space group | P 31 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 80.5, 80.5, 246.632, 90, 90, 120 |
| R / Rfree (%) | 19 / 22.2 |
Other elements in 7sgi:
The structure of Crystal Structure of Danio Rerio Histone Deacetylase 10 in Complex with Inhibitor 14 also contains other interesting chemical elements:
| Sodium | (Na) | 1 atom |
| Zinc | (Zn) | 1 atom |
Potassium Binding Sites:
The binding sites of Potassium atom in the Crystal Structure of Danio Rerio Histone Deacetylase 10 in Complex with Inhibitor 14
(pdb code 7sgi). This binding sites where shown within
5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Crystal Structure of Danio Rerio Histone Deacetylase 10 in Complex with Inhibitor 14, PDB code: 7sgi:
Jump to Potassium binding site number: 1; 2;
In total 2 binding sites of Potassium where determined in the Crystal Structure of Danio Rerio Histone Deacetylase 10 in Complex with Inhibitor 14, PDB code: 7sgi:
Jump to Potassium binding site number: 1; 2;
Potassium binding site 1 out of 2 in 7sgi
Go back to
Potassium Binding Sites List in 7sgi
Potassium binding site 1 out
of 2 in the Crystal Structure of Danio Rerio Histone Deacetylase 10 in Complex with Inhibitor 14
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 1 of Crystal Structure of Danio Rerio Histone Deacetylase 10 in Complex with Inhibitor 14 within 5.0Å range:
|
Potassium binding site 2 out of 2 in 7sgi
Go back to
Potassium Binding Sites List in 7sgi
Potassium binding site 2 out
of 2 in the Crystal Structure of Danio Rerio Histone Deacetylase 10 in Complex with Inhibitor 14
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 2 of Crystal Structure of Danio Rerio Histone Deacetylase 10 in Complex with Inhibitor 14 within 5.0Å range:
|
Reference:
R.R.Steimbach,
C.J.Herbst-Gervasoni,
S.Lechner,
T.M.Stewart,
G.Klinke,
J.Ridinger,
M.N.E.Geraldy,
G.Tihanyi,
J.R.Foley,
U.Uhrig,
B.Kuster,
G.Poschet,
R.A.Casero Jr.,
G.Medard,
I.Oehme,
D.W.Christianson,
N.Gunkel,
A.K.Miller.
Aza-Saha Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout. J.Am.Chem.Soc. V. 144 18861 2022.
ISSN: ESSN 1520-5126
PubMed: 36200994
DOI: 10.1021/JACS.2C05030
Page generated: Sat Aug 9 14:52:17 2025
ISSN: ESSN 1520-5126
PubMed: 36200994
DOI: 10.1021/JACS.2C05030
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