Potassium in PDB 7bym: Cryo-Em Structure of Human KCNQ4 with Retigabine

Other elements in 7bym:

The structure of Cryo-Em Structure of Human KCNQ4 with Retigabine also contains other interesting chemical elements:

Fluorine

(F)

4 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the Cryo-Em Structure of Human KCNQ4 with Retigabine (pdb code 7bym). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 3 binding sites of Potassium where determined in the Cryo-Em Structure of Human KCNQ4 with Retigabine, PDB code: 7bym:
Jump to Potassium binding site number: 1; 2; 3;

Potassium binding site 1 out of 3 in 7bym

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Potassium Binding Sites List in 7bym

Potassium binding site 1 out of 3 in the Cryo-Em Structure of Human KCNQ4 with Retigabine

Mono view

Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Cryo-Em Structure of Human KCNQ4 with Retigabine within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:K703 b:30.0 occ:1.00	O	E:GLY285	2.7	48.4	1.0
	O	E:TYR286	2.9	51.1	1.0
	O	C:GLY285	3.0	47.6	1.0
	O	A:GLY285	3.0	48.0	1.0
	O	G:GLY285	3.1	47.4	1.0
	O	C:TYR286	3.1	51.2	1.0
	O	A:TYR286	3.1	49.7	1.0
	O	G:TYR286	3.1	51.4	1.0
	C	E:TYR286	3.5	51.1	1.0
	C	C:TYR286	3.8	51.2	1.0
	C	A:TYR286	3.8	49.7	1.0
	C	G:TYR286	3.8	51.4	1.0
	C	E:GLY285	3.9	48.4	1.0
	CA	E:TYR286	4.1	51.1	1.0
	C	C:GLY285	4.1	47.6	1.0
	C	A:GLY285	4.2	48.0	1.0
	C	G:GLY285	4.3	47.4	1.0
	CA	C:TYR286	4.3	51.2	1.0
	N	E:GLY287	4.3	57.8	1.0
	CA	A:TYR286	4.4	49.7	1.0
	CA	G:TYR286	4.4	51.4	1.0
	N	E:TYR286	4.5	51.1	1.0
	N	C:GLY287	4.6	58.7	1.0
	N	A:GLY287	4.6	56.3	1.0
	CA	E:GLY287	4.7	57.8	1.0
	N	G:GLY287	4.7	58.5	1.0
	N	C:TYR286	4.8	51.2	1.0
	N	A:TYR286	4.8	49.7	1.0
	CA	C:GLY287	4.8	58.7	1.0
	N	G:TYR286	4.9	51.4	1.0
	CA	A:GLY287	4.9	56.3	1.0
	CA	G:GLY287	5.0	58.5	1.0

Potassium binding site 2 out of 3 in 7bym

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Potassium Binding Sites List in 7bym

Potassium binding site 2 out of 3 in the Cryo-Em Structure of Human KCNQ4 with Retigabine

Mono view

Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Cryo-Em Structure of Human KCNQ4 with Retigabine within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:K704 b:30.0 occ:1.00	O	E:ILE284	2.5	45.7	1.0
	O	C:ILE284	2.6	45.8	1.0
	O	A:ILE284	2.7	45.2	1.0
	O	G:ILE284	2.7	46.0	1.0
	O	E:THR283	3.3	49.9	1.0
	C	E:ILE284	3.4	45.7	1.0
	O	C:THR283	3.5	50.0	1.0
	O	A:THR283	3.6	49.6	1.0
	C	C:ILE284	3.6	45.8	1.0
	C	A:ILE284	3.7	45.2	1.0
	O	G:THR283	3.7	49.6	1.0
	C	G:ILE284	3.7	46.0	1.0
	CA	E:ILE284	4.2	45.7	1.0
	C	E:THR283	4.3	49.9	1.0
	K	A:K705	4.3	30.0	1.0
	CA	C:ILE284	4.3	45.8	1.0
	N	E:GLY285	4.3	48.4	1.0
	O	E:GLY285	4.3	48.4	1.0
	O	C:GLY285	4.3	47.6	1.0
	O	A:GLY285	4.4	48.0	1.0
	CA	A:ILE284	4.4	45.2	1.0
	O	G:GLY285	4.4	47.4	1.0
	N	C:GLY285	4.5	47.6	1.0
	CA	G:ILE284	4.5	46.0	1.0
	C	C:THR283	4.5	50.0	1.0
	CA	E:GLY285	4.5	48.4	1.0
	N	A:GLY285	4.6	48.0	1.0
	CA	C:GLY285	4.6	47.6	1.0
	C	A:THR283	4.6	49.6	1.0
	N	G:GLY285	4.6	47.4	1.0
	CA	A:GLY285	4.7	48.0	1.0
	C	G:THR283	4.7	49.6	1.0
	N	E:ILE284	4.7	45.7	1.0
	CA	G:GLY285	4.7	47.4	1.0
	C	E:GLY285	4.8	48.4	1.0
	C	C:GLY285	4.8	47.6	1.0
	C	A:GLY285	4.9	48.0	1.0
	N	C:ILE284	4.9	45.8	1.0
	C	G:GLY285	4.9	47.4	1.0
	N	A:ILE284	5.0	45.2	1.0

Potassium binding site 3 out of 3 in 7bym

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Potassium Binding Sites List in 7bym

Potassium binding site 3 out of 3 in the Cryo-Em Structure of Human KCNQ4 with Retigabine

Mono view

Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Cryo-Em Structure of Human KCNQ4 with Retigabine within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:K705 b:30.0 occ:1.00	O	E:THR283	3.0	49.9	1.0
	O	C:THR283	3.1	50.0	1.0
	O	A:THR283	3.2	49.6	1.0
	O	G:THR283	3.2	49.6	1.0
	OG1	E:THR283	3.3	49.9	1.0
	OG1	C:THR283	3.5	50.0	1.0
	CB	E:THR283	3.6	49.9	1.0
	OG1	A:THR283	3.7	49.6	1.0
	OG1	G:THR283	3.8	49.6	1.0
	CB	C:THR283	3.8	50.0	1.0
	C	E:THR283	3.9	49.9	1.0
	CB	A:THR283	4.0	49.6	1.0
	CB	G:THR283	4.0	49.6	1.0
	C	C:THR283	4.1	50.0	1.0
	C	A:THR283	4.2	49.6	1.0
	C	G:THR283	4.2	49.6	1.0
	K	A:K704	4.3	30.0	1.0
	CA	E:THR283	4.4	49.9	1.0
	CA	C:THR283	4.6	50.0	1.0
	CG2	E:THR283	4.8	49.9	1.0
	CA	A:THR283	4.8	49.6	1.0
	CA	G:THR283	4.8	49.6	1.0
	CG2	C:THR283	5.0	50.0	1.0

Reference:

T.Li, K.Wu, Z.Yue, Y.Wang, F.Zhang, H.Shen. Structural Basis For the Modulation of Human KCNQ4 By Small-Molecule Drugs. Mol.Cell 2020.
ISSN: ISSN 1097-2765
PubMed: 33238160
DOI: 10.1016/J.MOLCEL.2020.10.037

Page generated: Mon Aug 12 18:46:52 2024

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