Potassium in PDB 6z2k: The Structure of the Tetrameric HDAC1/Mideas/DNTTIP1 Midac Deacetylase Complex
Enzymatic activity of The Structure of the Tetrameric HDAC1/Mideas/DNTTIP1 Midac Deacetylase Complex
All present enzymatic activity of The Structure of the Tetrameric HDAC1/Mideas/DNTTIP1 Midac Deacetylase Complex:
3.5.1.98;
Other elements in 6z2k:
The structure of The Structure of the Tetrameric HDAC1/Mideas/DNTTIP1 Midac Deacetylase Complex also contains other interesting chemical elements:
Potassium Binding Sites:
The binding sites of Potassium atom in the The Structure of the Tetrameric HDAC1/Mideas/DNTTIP1 Midac Deacetylase Complex
(pdb code 6z2k). This binding sites where shown within
5.0 Angstroms radius around Potassium atom.
In total 8 binding sites of Potassium where determined in the
The Structure of the Tetrameric HDAC1/Mideas/DNTTIP1 Midac Deacetylase Complex, PDB code: 6z2k:
Jump to Potassium binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
Potassium binding site 1 out
of 8 in 6z2k
Go back to
Potassium Binding Sites List in 6z2k
Potassium binding site 1 out
of 8 in the The Structure of the Tetrameric HDAC1/Mideas/DNTTIP1 Midac Deacetylase Complex
 Mono view
 Stereo pair view
|
|
A full contact list of Potassium with other atoms in the K binding
site number 1 of The Structure of the Tetrameric HDAC1/Mideas/DNTTIP1 Midac Deacetylase Complex within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:K502
b:1.0
occ:1.00
|
HB3
|
C:ASP174
|
2.6
|
0.6
|
1.0
|
|
OD1
|
C:ASP174
|
2.8
|
0.6
|
1.0
|
|
O
|
C:PHE198
|
2.8
|
0.4
|
1.0
|
|
OG
|
C:SER197
|
2.8
|
0.9
|
1.0
|
|
O
|
C:ASP176
|
2.8
|
0.8
|
1.0
|
|
CG
|
C:ASP174
|
3.0
|
0.6
|
1.0
|
|
H
|
C:PHE198
|
3.1
|
0.4
|
1.0
|
|
O
|
C:ASP174
|
3.1
|
0.6
|
1.0
|
|
HB3
|
C:HIS199
|
3.1
|
0.8
|
1.0
|
|
CB
|
C:ASP174
|
3.2
|
0.6
|
1.0
|
|
HD1
|
C:HIS199
|
3.2
|
0.8
|
1.0
|
|
O
|
C:HIS178
|
3.3
|
0.3
|
1.0
|
|
HA
|
C:SER197
|
3.3
|
0.9
|
1.0
|
|
HA
|
C:HIS179
|
3.3
|
0.1
|
1.0
|
|
N
|
C:PHE198
|
3.5
|
0.4
|
1.0
|
|
C
|
C:ASP174
|
3.6
|
0.6
|
1.0
|
|
H
|
C:ASP176
|
3.6
|
0.8
|
1.0
|
|
H
|
C:GLY180
|
3.6
|
0.4
|
1.0
|
|
C
|
C:PHE198
|
3.7
|
0.4
|
1.0
|
|
N
|
C:ASP176
|
3.7
|
0.8
|
1.0
|
|
CB
|
C:SER197
|
3.7
|
0.9
|
1.0
|
|
OD2
|
C:ASP174
|
3.8
|
0.6
|
1.0
|
|
HB3
|
C:ASP176
|
3.8
|
0.8
|
1.0
|
|
C
|
C:ASP176
|
3.8
|
0.8
|
1.0
|
|
CA
|
C:SER197
|
3.8
|
0.9
|
1.0
|
|
HB2
|
C:SER197
|
3.9
|
0.9
|
1.0
|
|
C
|
C:SER197
|
4.0
|
0.9
|
1.0
|
|
ND1
|
C:HIS199
|
4.0
|
0.8
|
1.0
|
|
CA
|
C:ASP174
|
4.0
|
0.6
|
1.0
|
|
HB2
|
C:ASP174
|
4.0
|
0.6
|
1.0
|
|
C
|
C:ILE175
|
4.1
|
0.1
|
1.0
|
|
CB
|
C:HIS199
|
4.1
|
0.8
|
1.0
|
|
CA
|
C:ASP176
|
4.2
|
0.8
|
1.0
|
|
N
|
C:GLY180
|
4.2
|
0.4
|
1.0
|
|
CA
|
C:HIS179
|
4.2
|
0.1
|
1.0
|
|
C
|
C:HIS178
|
4.2
|
0.3
|
1.0
|
|
CA
|
C:PHE198
|
4.3
|
0.4
|
1.0
|
|
N
|
C:ILE175
|
4.3
|
0.1
|
1.0
|
|
O
|
C:ILE175
|
4.5
|
0.1
|
1.0
|
|
CB
|
C:ASP176
|
4.5
|
0.8
|
1.0
|
|
CG
|
C:HIS199
|
4.5
|
0.8
|
1.0
|
|
N
|
C:HIS199
|
4.6
|
0.8
|
1.0
|
|
HA
|
C:HIS199
|
4.6
|
0.8
|
1.0
|
|
HB3
|
C:SER197
|
4.6
|
0.9
|
1.0
|
|
HA
|
C:ILE175
|
4.6
|
0.1
|
1.0
|
|
CA
|
C:ILE175
|
4.6
|
0.1
|
1.0
|
|
HA
|
C:ASP174
|
4.6
|
0.6
|
1.0
|
|
C
|
C:HIS179
|
4.6
|
0.1
|
1.0
|
|
N
|
C:HIS179
|
4.7
|
0.1
|
1.0
|
|
CA
|
C:HIS199
|
4.7
|
0.8
|
1.0
|
|
HB2
|
C:HIS199
|
4.7
|
0.8
|
1.0
|
|
HD2
|
C:HIS179
|
4.7
|
0.1
|
1.0
|
|
HB2
|
C:PHE198
|
4.8
|
0.4
|
1.0
|
|
HB2
|
C:ASP176
|
4.9
|
0.8
|
1.0
|
|
H
|
C:ILE175
|
4.9
|
0.1
|
1.0
|
|
HA3
|
C:GLY180
|
4.9
|
0.4
|
1.0
|
|
HA
|
C:PHE198
|
5.0
|
0.4
|
1.0
|
|
H
|
C:ASP174
|
5.0
|
0.6
|
1.0
|
|
O
|
C:SER197
|
5.0
|
0.9
|
1.0
|
|
Potassium binding site 2 out
of 8 in 6z2k
Go back to
Potassium Binding Sites List in 6z2k
Potassium binding site 2 out
of 8 in the The Structure of the Tetrameric HDAC1/Mideas/DNTTIP1 Midac Deacetylase Complex
 Mono view
 Stereo pair view
|
|
A full contact list of Potassium with other atoms in the K binding
site number 2 of The Structure of the Tetrameric HDAC1/Mideas/DNTTIP1 Midac Deacetylase Complex within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:K503
b:0.1
occ:1.00
|
O
|
C:PHE187
|
2.7
|
0.9
|
1.0
|
|
O
|
C:VAL193
|
2.8
|
1.0
|
1.0
|
|
O
|
C:TYR222
|
2.9
|
0.7
|
1.0
|
|
O
|
C:THR190
|
3.0
|
0.7
|
1.0
|
|
HB3
|
C:TYR222
|
3.0
|
0.7
|
1.0
|
|
HB2
|
C:TYR222
|
3.0
|
0.7
|
1.0
|
|
CB
|
C:TYR222
|
3.5
|
0.7
|
1.0
|
|
C
|
C:TYR222
|
3.5
|
0.7
|
1.0
|
|
HB2
|
C:ALA223
|
3.7
|
0.9
|
1.0
|
|
H
|
C:THR190
|
3.7
|
0.7
|
1.0
|
|
HA3
|
C:GLY219
|
3.7
|
0.1
|
1.0
|
|
HG23
|
C:THR195
|
3.8
|
0.3
|
1.0
|
|
HA
|
C:TYR188
|
3.8
|
0.7
|
1.0
|
|
O
|
C:GLY219
|
3.8
|
0.1
|
1.0
|
|
HA2
|
C:GLY219
|
3.9
|
0.1
|
1.0
|
|
C
|
C:PHE187
|
3.9
|
0.9
|
1.0
|
|
HA
|
C:MET194
|
3.9
|
0.6
|
1.0
|
|
HG23
|
C:THR190
|
3.9
|
0.7
|
1.0
|
|
O
|
C:TYR188
|
4.0
|
0.7
|
1.0
|
|
C
|
C:VAL193
|
4.1
|
1.0
|
1.0
|
|
HB3
|
C:PHE187
|
4.1
|
0.9
|
1.0
|
|
C
|
C:THR190
|
4.1
|
0.7
|
1.0
|
|
CA
|
C:TYR222
|
4.1
|
0.7
|
1.0
|
|
C
|
C:TYR188
|
4.2
|
0.7
|
1.0
|
|
CA
|
C:GLY219
|
4.2
|
0.1
|
1.0
|
|
HG1
|
C:THR195
|
4.2
|
0.3
|
1.0
|
|
H
|
C:THR195
|
4.2
|
0.3
|
1.0
|
|
N
|
C:ALA223
|
4.3
|
0.9
|
1.0
|
|
HG22
|
C:THR190
|
4.3
|
0.7
|
1.0
|
|
CA
|
C:TYR188
|
4.4
|
0.7
|
1.0
|
|
N
|
C:THR190
|
4.4
|
0.7
|
1.0
|
|
HB
|
C:VAL193
|
4.4
|
1.0
|
1.0
|
|
HB2
|
C:PHE187
|
4.5
|
0.9
|
1.0
|
|
HA
|
C:ALA223
|
4.5
|
0.9
|
1.0
|
|
C
|
C:GLY219
|
4.5
|
0.1
|
1.0
|
|
CB
|
C:ALA223
|
4.5
|
0.9
|
1.0
|
|
H
|
C:VAL193
|
4.6
|
1.0
|
1.0
|
|
CG2
|
C:THR190
|
4.6
|
0.7
|
1.0
|
|
N
|
C:TYR188
|
4.6
|
0.7
|
1.0
|
|
HA
|
C:ASP191
|
4.6
|
0.1
|
1.0
|
|
CB
|
C:PHE187
|
4.7
|
0.9
|
1.0
|
|
CA
|
C:ALA223
|
4.7
|
0.9
|
1.0
|
|
CG2
|
C:THR195
|
4.7
|
0.3
|
1.0
|
|
H
|
C:TYR222
|
4.7
|
0.7
|
1.0
|
|
CG
|
C:TYR222
|
4.7
|
0.7
|
1.0
|
|
CA
|
C:MET194
|
4.7
|
0.6
|
1.0
|
|
N
|
C:THR189
|
4.8
|
0.8
|
1.0
|
|
HA
|
C:TYR222
|
4.8
|
0.7
|
1.0
|
|
CA
|
C:THR190
|
4.8
|
0.7
|
1.0
|
|
N
|
C:THR195
|
4.8
|
0.3
|
1.0
|
|
N
|
C:MET194
|
4.9
|
0.6
|
1.0
|
|
H
|
C:ALA223
|
4.9
|
0.9
|
1.0
|
|
HG21
|
C:THR195
|
4.9
|
0.3
|
1.0
|
|
OG1
|
C:THR195
|
4.9
|
0.3
|
1.0
|
|
CA
|
C:PHE187
|
4.9
|
0.9
|
1.0
|
|
N
|
C:TYR222
|
5.0
|
0.7
|
1.0
|
|
Potassium binding site 3 out
of 8 in 6z2k
Go back to
Potassium Binding Sites List in 6z2k
Potassium binding site 3 out
of 8 in the The Structure of the Tetrameric HDAC1/Mideas/DNTTIP1 Midac Deacetylase Complex
 Mono view
 Stereo pair view
|
|
A full contact list of Potassium with other atoms in the K binding
site number 3 of The Structure of the Tetrameric HDAC1/Mideas/DNTTIP1 Midac Deacetylase Complex within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
E:K503
b:0.1
occ:1.00
|
HB3
|
E:ASP174
|
2.6
|
0.2
|
1.0
|
|
OD1
|
E:ASP174
|
2.8
|
0.2
|
1.0
|
|
O
|
E:PHE198
|
2.8
|
0.5
|
1.0
|
|
OG
|
E:SER197
|
2.8
|
0.5
|
1.0
|
|
O
|
E:ASP176
|
2.8
|
0.2
|
1.0
|
|
CG
|
E:ASP174
|
3.0
|
0.2
|
1.0
|
|
H
|
E:PHE198
|
3.1
|
0.5
|
1.0
|
|
O
|
E:ASP174
|
3.1
|
0.2
|
1.0
|
|
HB3
|
E:HIS199
|
3.1
|
0.1
|
1.0
|
|
CB
|
E:ASP174
|
3.2
|
0.2
|
1.0
|
|
HD1
|
E:HIS199
|
3.2
|
0.1
|
1.0
|
|
O
|
E:HIS178
|
3.3
|
0.6
|
1.0
|
|
HA
|
E:SER197
|
3.3
|
0.5
|
1.0
|
|
HA
|
E:HIS179
|
3.3
|
0.5
|
1.0
|
|
N
|
E:PHE198
|
3.5
|
0.5
|
1.0
|
|
C
|
E:ASP174
|
3.6
|
0.2
|
1.0
|
|
H
|
E:ASP176
|
3.6
|
0.2
|
1.0
|
|
H
|
E:GLY180
|
3.6
|
0.0
|
1.0
|
|
C
|
E:PHE198
|
3.7
|
0.5
|
1.0
|
|
N
|
E:ASP176
|
3.7
|
0.2
|
1.0
|
|
CB
|
E:SER197
|
3.7
|
0.5
|
1.0
|
|
OD2
|
E:ASP174
|
3.8
|
0.2
|
1.0
|
|
HB3
|
E:ASP176
|
3.8
|
0.2
|
1.0
|
|
C
|
E:ASP176
|
3.8
|
0.2
|
1.0
|
|
CA
|
E:SER197
|
3.8
|
0.5
|
1.0
|
|
HB2
|
E:SER197
|
3.9
|
0.5
|
1.0
|
|
C
|
E:SER197
|
4.0
|
0.5
|
1.0
|
|
ND1
|
E:HIS199
|
4.0
|
0.1
|
1.0
|
|
CA
|
E:ASP174
|
4.0
|
0.2
|
1.0
|
|
HB2
|
E:ASP174
|
4.0
|
0.2
|
1.0
|
|
C
|
E:ILE175
|
4.1
|
0.6
|
1.0
|
|
CB
|
E:HIS199
|
4.1
|
0.1
|
1.0
|
|
CA
|
E:ASP176
|
4.2
|
0.2
|
1.0
|
|
N
|
E:GLY180
|
4.2
|
0.0
|
1.0
|
|
CA
|
E:HIS179
|
4.2
|
0.5
|
1.0
|
|
C
|
E:HIS178
|
4.2
|
0.6
|
1.0
|
|
CA
|
E:PHE198
|
4.3
|
0.5
|
1.0
|
|
N
|
E:ILE175
|
4.3
|
0.6
|
1.0
|
|
O
|
E:ILE175
|
4.5
|
0.6
|
1.0
|
|
CB
|
E:ASP176
|
4.5
|
0.2
|
1.0
|
|
CG
|
E:HIS199
|
4.5
|
0.1
|
1.0
|
|
HA
|
E:HIS199
|
4.6
|
0.1
|
1.0
|
|
N
|
E:HIS199
|
4.6
|
0.1
|
1.0
|
|
HB3
|
E:SER197
|
4.6
|
0.5
|
1.0
|
|
HA
|
E:ILE175
|
4.6
|
0.6
|
1.0
|
|
CA
|
E:ILE175
|
4.6
|
0.6
|
1.0
|
|
HA
|
E:ASP174
|
4.6
|
0.2
|
1.0
|
|
C
|
E:HIS179
|
4.6
|
0.5
|
1.0
|
|
N
|
E:HIS179
|
4.7
|
0.5
|
1.0
|
|
CA
|
E:HIS199
|
4.7
|
0.1
|
1.0
|
|
HB2
|
E:HIS199
|
4.7
|
0.1
|
1.0
|
|
HD2
|
E:HIS179
|
4.7
|
0.5
|
1.0
|
|
HB2
|
E:PHE198
|
4.8
|
0.5
|
1.0
|
|
HB2
|
E:ASP176
|
4.9
|
0.2
|
1.0
|
|
H
|
E:ILE175
|
4.9
|
0.6
|
1.0
|
|
HA3
|
E:GLY180
|
4.9
|
0.0
|
1.0
|
|
HA
|
E:PHE198
|
5.0
|
0.5
|
1.0
|
|
H
|
E:ASP174
|
5.0
|
0.2
|
1.0
|
|
O
|
E:SER197
|
5.0
|
0.5
|
1.0
|
|
Potassium binding site 4 out
of 8 in 6z2k
Go back to
Potassium Binding Sites List in 6z2k
Potassium binding site 4 out
of 8 in the The Structure of the Tetrameric HDAC1/Mideas/DNTTIP1 Midac Deacetylase Complex
 Mono view
 Stereo pair view
|
|
A full contact list of Potassium with other atoms in the K binding
site number 4 of The Structure of the Tetrameric HDAC1/Mideas/DNTTIP1 Midac Deacetylase Complex within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
E:K504
b:0.9
occ:1.00
|
O
|
E:PHE187
|
2.7
|
0.0
|
1.0
|
|
O
|
E:VAL193
|
2.8
|
0.9
|
1.0
|
|
O
|
E:TYR222
|
2.9
|
0.8
|
1.0
|
|
O
|
E:THR190
|
3.0
|
0.1
|
1.0
|
|
HB3
|
E:TYR222
|
3.0
|
0.8
|
1.0
|
|
HB2
|
E:TYR222
|
3.0
|
0.8
|
1.0
|
|
CB
|
E:TYR222
|
3.5
|
0.8
|
1.0
|
|
C
|
E:TYR222
|
3.5
|
0.8
|
1.0
|
|
HB2
|
E:ALA223
|
3.7
|
0.6
|
1.0
|
|
H
|
E:THR190
|
3.7
|
0.1
|
1.0
|
|
HA3
|
E:GLY219
|
3.7
|
0.7
|
1.0
|
|
HG23
|
E:THR195
|
3.8
|
0.0
|
1.0
|
|
HA
|
E:TYR188
|
3.8
|
0.6
|
1.0
|
|
O
|
E:GLY219
|
3.8
|
0.7
|
1.0
|
|
HA2
|
E:GLY219
|
3.9
|
0.7
|
1.0
|
|
C
|
E:PHE187
|
3.9
|
0.0
|
1.0
|
|
HA
|
E:MET194
|
3.9
|
0.8
|
1.0
|
|
HG23
|
E:THR190
|
3.9
|
0.1
|
1.0
|
|
O
|
E:TYR188
|
4.0
|
0.6
|
1.0
|
|
C
|
E:VAL193
|
4.1
|
0.9
|
1.0
|
|
HB3
|
E:PHE187
|
4.1
|
0.0
|
1.0
|
|
C
|
E:THR190
|
4.1
|
0.1
|
1.0
|
|
CA
|
E:TYR222
|
4.1
|
0.8
|
1.0
|
|
C
|
E:TYR188
|
4.2
|
0.6
|
1.0
|
|
CA
|
E:GLY219
|
4.2
|
0.7
|
1.0
|
|
HG1
|
E:THR195
|
4.2
|
0.0
|
1.0
|
|
H
|
E:THR195
|
4.2
|
0.0
|
1.0
|
|
N
|
E:ALA223
|
4.3
|
0.6
|
1.0
|
|
HG22
|
E:THR190
|
4.3
|
0.1
|
1.0
|
|
CA
|
E:TYR188
|
4.4
|
0.6
|
1.0
|
|
N
|
E:THR190
|
4.4
|
0.1
|
1.0
|
|
HB
|
E:VAL193
|
4.4
|
0.9
|
1.0
|
|
HB2
|
E:PHE187
|
4.5
|
0.0
|
1.0
|
|
HA
|
E:ALA223
|
4.5
|
0.6
|
1.0
|
|
C
|
E:GLY219
|
4.5
|
0.7
|
1.0
|
|
CB
|
E:ALA223
|
4.5
|
0.6
|
1.0
|
|
H
|
E:VAL193
|
4.6
|
0.9
|
1.0
|
|
CG2
|
E:THR190
|
4.6
|
0.1
|
1.0
|
|
N
|
E:TYR188
|
4.6
|
0.6
|
1.0
|
|
HA
|
E:ASP191
|
4.6
|
0.2
|
1.0
|
|
CB
|
E:PHE187
|
4.7
|
0.0
|
1.0
|
|
CA
|
E:ALA223
|
4.7
|
0.6
|
1.0
|
|
CG2
|
E:THR195
|
4.7
|
0.0
|
1.0
|
|
H
|
E:TYR222
|
4.7
|
0.8
|
1.0
|
|
CG
|
E:TYR222
|
4.7
|
0.8
|
1.0
|
|
CA
|
E:MET194
|
4.7
|
0.8
|
1.0
|
|
N
|
E:THR189
|
4.8
|
0.5
|
1.0
|
|
HA
|
E:TYR222
|
4.8
|
0.8
|
1.0
|
|
CA
|
E:THR190
|
4.8
|
0.1
|
1.0
|
|
N
|
E:THR195
|
4.8
|
0.0
|
1.0
|
|
N
|
E:MET194
|
4.9
|
0.8
|
1.0
|
|
H
|
E:ALA223
|
4.9
|
0.6
|
1.0
|
|
HG21
|
E:THR195
|
4.9
|
0.0
|
1.0
|
|
OG1
|
E:THR195
|
4.9
|
0.0
|
1.0
|
|
CA
|
E:PHE187
|
4.9
|
0.0
|
1.0
|
|
N
|
E:TYR222
|
5.0
|
0.8
|
1.0
|
|
Potassium binding site 5 out
of 8 in 6z2k
Go back to
Potassium Binding Sites List in 6z2k
Potassium binding site 5 out
of 8 in the The Structure of the Tetrameric HDAC1/Mideas/DNTTIP1 Midac Deacetylase Complex
 Mono view
 Stereo pair view
|
|
A full contact list of Potassium with other atoms in the K binding
site number 5 of The Structure of the Tetrameric HDAC1/Mideas/DNTTIP1 Midac Deacetylase Complex within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
K:K502
b:0.7
occ:1.00
|
HB3
|
K:ASP174
|
2.6
|
0.6
|
1.0
|
|
OD1
|
K:ASP174
|
2.8
|
0.6
|
1.0
|
|
O
|
K:PHE198
|
2.8
|
0.3
|
1.0
|
|
OG
|
K:SER197
|
2.8
|
0.2
|
1.0
|
|
O
|
K:ASP176
|
2.8
|
0.8
|
1.0
|
|
CG
|
K:ASP174
|
3.0
|
0.6
|
1.0
|
|
H
|
K:PHE198
|
3.1
|
0.3
|
1.0
|
|
O
|
K:ASP174
|
3.1
|
0.6
|
1.0
|
|
HB3
|
K:HIS199
|
3.1
|
0.7
|
1.0
|
|
CB
|
K:ASP174
|
3.2
|
0.6
|
1.0
|
|
HD1
|
K:HIS199
|
3.2
|
0.7
|
1.0
|
|
O
|
K:HIS178
|
3.3
|
0.9
|
1.0
|
|
HA
|
K:SER197
|
3.3
|
0.2
|
1.0
|
|
HA
|
K:HIS179
|
3.3
|
0.3
|
1.0
|
|
N
|
K:PHE198
|
3.5
|
0.3
|
1.0
|
|
C
|
K:ASP174
|
3.6
|
0.6
|
1.0
|
|
H
|
K:ASP176
|
3.6
|
0.8
|
1.0
|
|
H
|
K:GLY180
|
3.6
|
0.1
|
1.0
|
|
C
|
K:PHE198
|
3.7
|
0.3
|
1.0
|
|
N
|
K:ASP176
|
3.7
|
0.8
|
1.0
|
|
CB
|
K:SER197
|
3.7
|
0.2
|
1.0
|
|
OD2
|
K:ASP174
|
3.8
|
0.6
|
1.0
|
|
HB3
|
K:ASP176
|
3.8
|
0.8
|
1.0
|
|
C
|
K:ASP176
|
3.8
|
0.8
|
1.0
|
|
CA
|
K:SER197
|
3.8
|
0.2
|
1.0
|
|
HB2
|
K:SER197
|
3.9
|
0.2
|
1.0
|
|
C
|
K:SER197
|
4.0
|
0.2
|
1.0
|
|
ND1
|
K:HIS199
|
4.0
|
0.7
|
1.0
|
|
CA
|
K:ASP174
|
4.0
|
0.6
|
1.0
|
|
HB2
|
K:ASP174
|
4.0
|
0.6
|
1.0
|
|
C
|
K:ILE175
|
4.1
|
0.2
|
1.0
|
|
CB
|
K:HIS199
|
4.1
|
0.7
|
1.0
|
|
CA
|
K:ASP176
|
4.2
|
0.8
|
1.0
|
|
N
|
K:GLY180
|
4.2
|
0.1
|
1.0
|
|
CA
|
K:HIS179
|
4.2
|
0.3
|
1.0
|
|
C
|
K:HIS178
|
4.2
|
0.9
|
1.0
|
|
CA
|
K:PHE198
|
4.3
|
0.3
|
1.0
|
|
N
|
K:ILE175
|
4.3
|
0.2
|
1.0
|
|
O
|
K:ILE175
|
4.5
|
0.2
|
1.0
|
|
CB
|
K:ASP176
|
4.5
|
0.8
|
1.0
|
|
CG
|
K:HIS199
|
4.5
|
0.7
|
1.0
|
|
HA
|
K:HIS199
|
4.6
|
0.7
|
1.0
|
|
N
|
K:HIS199
|
4.6
|
0.7
|
1.0
|
|
HB3
|
K:SER197
|
4.6
|
0.2
|
1.0
|
|
HA
|
K:ILE175
|
4.6
|
0.2
|
1.0
|
|
CA
|
K:ILE175
|
4.6
|
0.2
|
1.0
|
|
HA
|
K:ASP174
|
4.6
|
0.6
|
1.0
|
|
C
|
K:HIS179
|
4.6
|
0.3
|
1.0
|
|
N
|
K:HIS179
|
4.7
|
0.3
|
1.0
|
|
CA
|
K:HIS199
|
4.7
|
0.7
|
1.0
|
|
HB2
|
K:HIS199
|
4.7
|
0.7
|
1.0
|
|
HD2
|
K:HIS179
|
4.7
|
0.3
|
1.0
|
|
HB2
|
K:PHE198
|
4.8
|
0.3
|
1.0
|
|
HB2
|
K:ASP176
|
4.9
|
0.8
|
1.0
|
|
H
|
K:ILE175
|
4.9
|
0.2
|
1.0
|
|
HA3
|
K:GLY180
|
4.9
|
0.1
|
1.0
|
|
HA
|
K:PHE198
|
5.0
|
0.3
|
1.0
|
|
H
|
K:ASP174
|
5.0
|
0.6
|
1.0
|
|
O
|
K:SER197
|
5.0
|
0.2
|
1.0
|
|
Potassium binding site 6 out
of 8 in 6z2k
Go back to
Potassium Binding Sites List in 6z2k
Potassium binding site 6 out
of 8 in the The Structure of the Tetrameric HDAC1/Mideas/DNTTIP1 Midac Deacetylase Complex
 Mono view
 Stereo pair view
|
|
A full contact list of Potassium with other atoms in the K binding
site number 6 of The Structure of the Tetrameric HDAC1/Mideas/DNTTIP1 Midac Deacetylase Complex within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
K:K503
b:0.4
occ:1.00
|
O
|
K:PHE187
|
2.7
|
0.7
|
1.0
|
|
O
|
K:VAL193
|
2.8
|
0.5
|
1.0
|
|
O
|
K:TYR222
|
2.9
|
0.1
|
1.0
|
|
O
|
K:THR190
|
3.0
|
0.7
|
1.0
|
|
HB3
|
K:TYR222
|
3.0
|
0.1
|
1.0
|
|
HB2
|
K:TYR222
|
3.0
|
0.1
|
1.0
|
|
CB
|
K:TYR222
|
3.5
|
0.1
|
1.0
|
|
C
|
K:TYR222
|
3.5
|
0.1
|
1.0
|
|
HB2
|
K:ALA223
|
3.7
|
0.1
|
1.0
|
|
H
|
K:THR190
|
3.7
|
0.7
|
1.0
|
|
HA3
|
K:GLY219
|
3.7
|
0.6
|
1.0
|
|
HG23
|
K:THR195
|
3.8
|
0.4
|
1.0
|
|
HA
|
K:TYR188
|
3.8
|
0.3
|
1.0
|
|
O
|
K:GLY219
|
3.8
|
0.6
|
1.0
|
|
HA2
|
K:GLY219
|
3.9
|
0.6
|
1.0
|
|
C
|
K:PHE187
|
3.9
|
0.7
|
1.0
|
|
HA
|
K:MET194
|
3.9
|
0.2
|
1.0
|
|
HG23
|
K:THR190
|
3.9
|
0.7
|
1.0
|
|
O
|
K:TYR188
|
4.0
|
0.3
|
1.0
|
|
C
|
K:VAL193
|
4.1
|
0.5
|
1.0
|
|
HB3
|
K:PHE187
|
4.1
|
0.7
|
1.0
|
|
C
|
K:THR190
|
4.1
|
0.7
|
1.0
|
|
CA
|
K:TYR222
|
4.1
|
0.1
|
1.0
|
|
C
|
K:TYR188
|
4.2
|
0.3
|
1.0
|
|
CA
|
K:GLY219
|
4.2
|
0.6
|
1.0
|
|
HG1
|
K:THR195
|
4.2
|
0.4
|
1.0
|
|
H
|
K:THR195
|
4.2
|
0.4
|
1.0
|
|
N
|
K:ALA223
|
4.3
|
0.1
|
1.0
|
|
HG22
|
K:THR190
|
4.3
|
0.7
|
1.0
|
|
CA
|
K:TYR188
|
4.4
|
0.3
|
1.0
|
|
N
|
K:THR190
|
4.4
|
0.7
|
1.0
|
|
HB
|
K:VAL193
|
4.4
|
0.5
|
1.0
|
|
HB2
|
K:PHE187
|
4.5
|
0.7
|
1.0
|
|
HA
|
K:ALA223
|
4.5
|
0.1
|
1.0
|
|
C
|
K:GLY219
|
4.5
|
0.6
|
1.0
|
|
CB
|
K:ALA223
|
4.5
|
0.1
|
1.0
|
|
H
|
K:VAL193
|
4.6
|
0.5
|
1.0
|
|
CG2
|
K:THR190
|
4.6
|
0.7
|
1.0
|
|
N
|
K:TYR188
|
4.6
|
0.3
|
1.0
|
|
HA
|
K:ASP191
|
4.6
|
0.1
|
1.0
|
|
CB
|
K:PHE187
|
4.7
|
0.7
|
1.0
|
|
CA
|
K:ALA223
|
4.7
|
0.1
|
1.0
|
|
CG2
|
K:THR195
|
4.7
|
0.4
|
1.0
|
|
H
|
K:TYR222
|
4.7
|
0.1
|
1.0
|
|
CG
|
K:TYR222
|
4.7
|
0.1
|
1.0
|
|
CA
|
K:MET194
|
4.7
|
0.2
|
1.0
|
|
N
|
K:THR189
|
4.8
|
0.8
|
1.0
|
|
HA
|
K:TYR222
|
4.8
|
0.1
|
1.0
|
|
CA
|
K:THR190
|
4.8
|
0.7
|
1.0
|
|
N
|
K:THR195
|
4.8
|
0.4
|
1.0
|
|
N
|
K:MET194
|
4.9
|
0.2
|
1.0
|
|
H
|
K:ALA223
|
4.9
|
0.1
|
1.0
|
|
HG21
|
K:THR195
|
4.9
|
0.4
|
1.0
|
|
OG1
|
K:THR195
|
4.9
|
0.4
|
1.0
|
|
CA
|
K:PHE187
|
4.9
|
0.7
|
1.0
|
|
N
|
K:TYR222
|
5.0
|
0.1
|
1.0
|
|
Potassium binding site 7 out
of 8 in 6z2k
Go back to
Potassium Binding Sites List in 6z2k
Potassium binding site 7 out
of 8 in the The Structure of the Tetrameric HDAC1/Mideas/DNTTIP1 Midac Deacetylase Complex
 Mono view
 Stereo pair view
|
|
A full contact list of Potassium with other atoms in the K binding
site number 7 of The Structure of the Tetrameric HDAC1/Mideas/DNTTIP1 Midac Deacetylase Complex within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
I:K502
b:0.2
occ:1.00
|
HB3
|
I:ASP174
|
2.6
|
0.9
|
1.0
|
|
OD1
|
I:ASP174
|
2.8
|
0.9
|
1.0
|
|
O
|
I:PHE198
|
2.8
|
0.2
|
1.0
|
|
OG
|
I:SER197
|
2.8
|
0.9
|
1.0
|
|
O
|
I:ASP176
|
2.8
|
1.0
|
1.0
|
|
CG
|
I:ASP174
|
3.0
|
0.9
|
1.0
|
|
H
|
I:PHE198
|
3.1
|
0.2
|
1.0
|
|
O
|
I:ASP174
|
3.1
|
0.9
|
1.0
|
|
HB3
|
I:HIS199
|
3.1
|
0.1
|
1.0
|
|
CB
|
I:ASP174
|
3.2
|
0.9
|
1.0
|
|
HD1
|
I:HIS199
|
3.2
|
0.1
|
1.0
|
|
O
|
I:HIS178
|
3.3
|
1.0
|
1.0
|
|
HA
|
I:SER197
|
3.3
|
0.9
|
1.0
|
|
HA
|
I:HIS179
|
3.3
|
0.0
|
1.0
|
|
N
|
I:PHE198
|
3.5
|
0.2
|
1.0
|
|
C
|
I:ASP174
|
3.6
|
0.9
|
1.0
|
|
H
|
I:ASP176
|
3.6
|
1.0
|
1.0
|
|
H
|
I:GLY180
|
3.6
|
0.9
|
1.0
|
|
C
|
I:PHE198
|
3.7
|
0.2
|
1.0
|
|
N
|
I:ASP176
|
3.7
|
1.0
|
1.0
|
|
CB
|
I:SER197
|
3.7
|
0.9
|
1.0
|
|
OD2
|
I:ASP174
|
3.8
|
0.9
|
1.0
|
|
HB3
|
I:ASP176
|
3.8
|
1.0
|
1.0
|
|
C
|
I:ASP176
|
3.8
|
1.0
|
1.0
|
|
CA
|
I:SER197
|
3.8
|
0.9
|
1.0
|
|
HB2
|
I:SER197
|
4.0
|
0.9
|
1.0
|
|
C
|
I:SER197
|
4.0
|
0.9
|
1.0
|
|
ND1
|
I:HIS199
|
4.0
|
0.1
|
1.0
|
|
CA
|
I:ASP174
|
4.0
|
0.9
|
1.0
|
|
HB2
|
I:ASP174
|
4.0
|
0.9
|
1.0
|
|
C
|
I:ILE175
|
4.1
|
0.2
|
1.0
|
|
CB
|
I:HIS199
|
4.1
|
0.1
|
1.0
|
|
CA
|
I:ASP176
|
4.2
|
1.0
|
1.0
|
|
N
|
I:GLY180
|
4.2
|
0.9
|
1.0
|
|
CA
|
I:HIS179
|
4.2
|
0.0
|
1.0
|
|
C
|
I:HIS178
|
4.2
|
1.0
|
1.0
|
|
CA
|
I:PHE198
|
4.3
|
0.2
|
1.0
|
|
N
|
I:ILE175
|
4.3
|
0.2
|
1.0
|
|
O
|
I:ILE175
|
4.5
|
0.2
|
1.0
|
|
CB
|
I:ASP176
|
4.5
|
1.0
|
1.0
|
|
CG
|
I:HIS199
|
4.5
|
0.1
|
1.0
|
|
N
|
I:HIS199
|
4.6
|
0.1
|
1.0
|
|
HA
|
I:HIS199
|
4.6
|
0.1
|
1.0
|
|
HB3
|
I:SER197
|
4.6
|
0.9
|
1.0
|
|
HA
|
I:ILE175
|
4.6
|
0.2
|
1.0
|
|
CA
|
I:ILE175
|
4.6
|
0.2
|
1.0
|
|
HA
|
I:ASP174
|
4.6
|
0.9
|
1.0
|
|
C
|
I:HIS179
|
4.6
|
0.0
|
1.0
|
|
N
|
I:HIS179
|
4.7
|
0.0
|
1.0
|
|
CA
|
I:HIS199
|
4.7
|
0.1
|
1.0
|
|
HB2
|
I:HIS199
|
4.7
|
0.1
|
1.0
|
|
HD2
|
I:HIS179
|
4.7
|
0.0
|
1.0
|
|
HB2
|
I:PHE198
|
4.8
|
0.2
|
1.0
|
|
HB2
|
I:ASP176
|
4.9
|
1.0
|
1.0
|
|
H
|
I:ILE175
|
4.9
|
0.2
|
1.0
|
|
HA3
|
I:GLY180
|
4.9
|
0.9
|
1.0
|
|
HA
|
I:PHE198
|
5.0
|
0.2
|
1.0
|
|
H
|
I:ASP174
|
5.0
|
0.9
|
1.0
|
|
O
|
I:SER197
|
5.0
|
0.9
|
1.0
|
|
Potassium binding site 8 out
of 8 in 6z2k
Go back to
Potassium Binding Sites List in 6z2k
Potassium binding site 8 out
of 8 in the The Structure of the Tetrameric HDAC1/Mideas/DNTTIP1 Midac Deacetylase Complex
 Mono view
 Stereo pair view
|
|
A full contact list of Potassium with other atoms in the K binding
site number 8 of The Structure of the Tetrameric HDAC1/Mideas/DNTTIP1 Midac Deacetylase Complex within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
I:K503
b:0.6
occ:1.00
|
O
|
I:PHE187
|
2.7
|
0.1
|
1.0
|
|
O
|
I:VAL193
|
2.8
|
0.4
|
1.0
|
|
O
|
I:TYR222
|
2.9
|
0.6
|
1.0
|
|
O
|
I:THR190
|
3.0
|
0.5
|
1.0
|
|
HB3
|
I:TYR222
|
3.0
|
0.6
|
1.0
|
|
HB2
|
I:TYR222
|
3.0
|
0.6
|
1.0
|
|
CB
|
I:TYR222
|
3.5
|
0.6
|
1.0
|
|
C
|
I:TYR222
|
3.5
|
0.6
|
1.0
|
|
HB2
|
I:ALA223
|
3.7
|
0.1
|
1.0
|
|
H
|
I:THR190
|
3.7
|
0.5
|
1.0
|
|
HA3
|
I:GLY219
|
3.7
|
0.9
|
1.0
|
|
HG23
|
I:THR195
|
3.8
|
0.1
|
1.0
|
|
HA
|
I:TYR188
|
3.8
|
0.5
|
1.0
|
|
O
|
I:GLY219
|
3.8
|
0.9
|
1.0
|
|
HA2
|
I:GLY219
|
3.9
|
0.9
|
1.0
|
|
C
|
I:PHE187
|
3.9
|
0.1
|
1.0
|
|
HA
|
I:MET194
|
3.9
|
0.4
|
1.0
|
|
HG23
|
I:THR190
|
3.9
|
0.5
|
1.0
|
|
O
|
I:TYR188
|
4.0
|
0.5
|
1.0
|
|
C
|
I:VAL193
|
4.1
|
0.4
|
1.0
|
|
HB3
|
I:PHE187
|
4.1
|
0.1
|
1.0
|
|
C
|
I:THR190
|
4.1
|
0.5
|
1.0
|
|
CA
|
I:TYR222
|
4.1
|
0.6
|
1.0
|
|
C
|
I:TYR188
|
4.2
|
0.5
|
1.0
|
|
CA
|
I:GLY219
|
4.2
|
0.9
|
1.0
|
|
HG1
|
I:THR195
|
4.2
|
0.1
|
1.0
|
|
H
|
I:THR195
|
4.2
|
0.1
|
1.0
|
|
N
|
I:ALA223
|
4.3
|
0.1
|
1.0
|
|
HG22
|
I:THR190
|
4.3
|
0.5
|
1.0
|
|
CA
|
I:TYR188
|
4.4
|
0.5
|
1.0
|
|
N
|
I:THR190
|
4.4
|
0.5
|
1.0
|
|
HB
|
I:VAL193
|
4.4
|
0.4
|
1.0
|
|
HB2
|
I:PHE187
|
4.5
|
0.1
|
1.0
|
|
HA
|
I:ALA223
|
4.5
|
0.1
|
1.0
|
|
C
|
I:GLY219
|
4.5
|
0.9
|
1.0
|
|
CB
|
I:ALA223
|
4.5
|
0.1
|
1.0
|
|
H
|
I:VAL193
|
4.6
|
0.4
|
1.0
|
|
CG2
|
I:THR190
|
4.6
|
0.5
|
1.0
|
|
N
|
I:TYR188
|
4.6
|
0.5
|
1.0
|
|
HA
|
I:ASP191
|
4.6
|
0.2
|
1.0
|
|
CB
|
I:PHE187
|
4.7
|
0.1
|
1.0
|
|
CA
|
I:ALA223
|
4.7
|
0.1
|
1.0
|
|
CG2
|
I:THR195
|
4.7
|
0.1
|
1.0
|
|
H
|
I:TYR222
|
4.7
|
0.6
|
1.0
|
|
CG
|
I:TYR222
|
4.7
|
0.6
|
1.0
|
|
CA
|
I:MET194
|
4.7
|
0.4
|
1.0
|
|
N
|
I:THR189
|
4.8
|
0.2
|
1.0
|
|
HA
|
I:TYR222
|
4.8
|
0.6
|
1.0
|
|
CA
|
I:THR190
|
4.8
|
0.5
|
1.0
|
|
N
|
I:THR195
|
4.8
|
0.1
|
1.0
|
|
N
|
I:MET194
|
4.9
|
0.4
|
1.0
|
|
H
|
I:ALA223
|
4.9
|
0.1
|
1.0
|
|
HG21
|
I:THR195
|
4.9
|
0.1
|
1.0
|
|
OG1
|
I:THR195
|
4.9
|
0.1
|
1.0
|
|
CA
|
I:PHE187
|
4.9
|
0.1
|
1.0
|
|
N
|
I:TYR222
|
5.0
|
0.6
|
1.0
|
|
Reference:
R.E.Turnbull,
L.Fairall,
A.Saleh,
E.Kelsall,
K.L.Morris,
T.J.Ragan,
C.G.Savva,
A.Chandru,
C.J.Millard,
O.V.Makarova,
C.J.Smith,
A.M.Roseman,
A.M.Fry,
S.M.Cowley,
J.W.R.Schwabe.
The Midac Histone Deacetylase Complex Is Essential For Embryonic Development and Has A Unique Multivalent Structure. Nat Commun V. 11 3252 2020.
ISSN: ESSN 2041-1723
PubMed: 32591534
DOI: 10.1038/S41467-020-17078-8
Page generated: Sat Aug 9 12:50:15 2025
|
