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Potassium in PDB 6wc9: Human Open State TMEM175 in Kcl

Potassium Binding Sites:

The binding sites of Potassium atom in the Human Open State TMEM175 in Kcl (pdb code 6wc9). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 7 binding sites of Potassium where determined in the Human Open State TMEM175 in Kcl, PDB code: 6wc9:
Jump to Potassium binding site number: 1; 2; 3; 4; 5; 6; 7;

Potassium binding site 1 out of 7 in 6wc9

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Potassium binding site 1 out of 7 in the Human Open State TMEM175 in Kcl


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Human Open State TMEM175 in Kcl within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K701

b:40.7
occ:1.00
 K B:K701 2.9 41.3 1.0
HB2 A:ALA263 3.2 18.8 1.0
HB3 A:SER38 3.2 20.4 1.0
HB1 A:ALA263 3.5 18.8 1.0
O A:HOH826 3.6 16.1 1.0
HG A:SER38 3.6 20.4 1.0
OG A:SER38 3.7 20.4 1.0
CB A:ALA263 3.8 18.8 1.0
CB A:SER38 3.9 20.4 1.0
O B:HOH812 3.9 23.2 1.0
O A:HOH811 4.0 23.3 1.0
HB3 B:SER38 4.0 20.4 1.0
O A:HOH846 4.0 22.5 1.0
O A:HOH843 4.0 20.7 1.0
HA A:SER38 4.1 20.4 1.0
HG B:SER38 4.2 20.4 1.0
HA A:ALA263 4.2 18.8 1.0
HB3 A:ALA263 4.5 18.8 1.0
O A:HOH807 4.6 19.9 1.0
O A:HOH847 4.6 26.3 1.0
CA A:SER38 4.6 20.4 1.0
CA A:ALA263 4.6 18.8 1.0
HB2 A:SER38 4.7 20.4 1.0
OG B:SER38 4.7 20.4 1.0
CB B:SER38 4.8 20.4 1.0
O B:HOH846 4.9 22.4 1.0

Potassium binding site 2 out of 7 in 6wc9

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Potassium binding site 2 out of 7 in the Human Open State TMEM175 in Kcl


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Human Open State TMEM175 in Kcl within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K702

b:42.7
occ:1.00
 O A:HOH816 2.7 19.6 1.0
K B:K702 2.8 43.7 1.0
HA2 A:GLY267 2.9 17.7 1.0
O A:HOH808 3.0 16.9 1.0
HA3 A:GLY267 3.1 17.7 1.0
O A:HOH842 3.1 24.7 1.0
HB1 B:ALA42 3.3 18.2 1.0
HA A:ALA42 3.4 18.3 1.0
CA A:GLY267 3.4 17.7 1.0
HB2 B:ALA42 3.5 18.2 1.0
HB2 A:ALA42 3.6 18.3 1.0
HB1 A:ALA42 3.7 18.3 1.0
CB B:ALA42 3.9 18.2 1.0
CB A:ALA42 4.0 18.3 1.0
N A:GLY267 4.0 17.7 1.0
H A:GLY267 4.1 17.7 1.0
CA A:ALA42 4.1 18.3 1.0
HG A:SER45 4.1 18.4 1.0
OG A:SER45 4.2 18.4 1.0
O B:HOH842 4.3 24.8 1.0
O A:HOH846 4.4 22.5 1.0
O A:HOH826 4.4 16.1 1.0
HB3 B:ALA42 4.5 18.2 1.0
O B:HOH808 4.6 17.1 1.0
HA B:ALA42 4.7 18.2 1.0
C A:GLY267 4.7 17.7 1.0
O A:ALA263 4.7 18.8 1.0
O B:HOH816 4.8 19.8 1.0
C A:ASP266 4.9 18.7 1.0
HB3 A:ALA42 4.9 18.3 1.0
CA B:ALA42 4.9 18.2 1.0
N A:ALA42 5.0 18.3 1.0

Potassium binding site 3 out of 7 in 6wc9

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Potassium binding site 3 out of 7 in the Human Open State TMEM175 in Kcl


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Human Open State TMEM175 in Kcl within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K703

b:52.9
occ:1.00
 O A:HOH850 2.7 25.7 1.0
O A:HOH852 2.8 25.7 1.0
O B:HOH853 2.8 34.1 1.0
O A:HOH853 2.8 33.8 1.0
K B:K703 3.3 53.3 1.0
HD13 A:LEU53 3.5 35.0 1.0
HD23 A:LEU278 3.6 30.0 1.0
HG23 A:ILE271 3.7 20.6 1.0
O A:HOH819 3.8 23.5 1.0
O A:HOH820 3.8 23.0 1.0
HD22 A:LEU278 3.8 30.0 1.0
HD21 A:LEU53 3.9 35.0 1.0
HD23 A:LEU275 3.9 27.6 1.0
HD21 B:LEU278 3.9 30.0 1.0
CD2 A:LEU278 4.0 30.0 1.0
HD21 A:LEU278 4.0 30.0 1.0
HD23 B:LEU278 4.0 30.0 1.0
O B:HOH852 4.0 26.0 1.0
HD21 A:LEU275 4.1 27.6 1.0
HG21 A:ILE271 4.1 20.6 1.0
CG2 A:ILE271 4.4 20.6 1.0
O B:HOH850 4.4 25.6 1.0
CD1 A:LEU53 4.4 35.0 1.0
CD2 B:LEU278 4.4 30.0 1.0
CD2 A:LEU275 4.5 27.6 1.0
HG12 A:ILE271 4.6 20.6 1.0
CD2 A:LEU53 4.7 35.0 1.0
HD12 A:LEU53 4.8 35.0 1.0
HG A:LEU275 4.9 27.6 1.0
HD11 A:LEU53 4.9 35.0 1.0
K A:K704 4.9 41.9 1.0
HD22 B:LEU278 4.9 30.0 1.0
HG22 A:ILE271 4.9 20.6 1.0
HG A:LEU53 5.0 35.0 1.0

Potassium binding site 4 out of 7 in 6wc9

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Potassium binding site 4 out of 7 in the Human Open State TMEM175 in Kcl


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Human Open State TMEM175 in Kcl within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K704

b:41.9
occ:1.00
 HG12 B:ILE46 2.8 20.7 1.0
HG12 A:ILE46 2.8 20.7 1.0
HG12 A:ILE271 2.9 20.6 1.0
HG12 B:ILE271 2.9 20.5 1.0
O B:HOH850 3.4 25.6 1.0
O A:HOH850 3.4 25.7 1.0
HD11 B:ILE46 3.5 20.7 1.0
HD11 A:ILE46 3.5 20.7 1.0
CG1 B:ILE46 3.6 20.7 1.0
CG1 A:ILE46 3.6 20.7 1.0
HD11 B:ILE271 3.6 20.5 1.0
HD11 A:ILE271 3.6 20.6 1.0
CG1 A:ILE271 3.6 20.6 1.0
CG1 B:ILE271 3.7 20.5 1.0
HD13 B:ILE46 3.7 20.7 1.0
HD13 A:ILE46 3.7 20.7 1.0
O B:HOH852 3.7 26.0 1.0
O A:HOH852 3.7 25.7 1.0
HG13 A:ILE271 3.8 20.6 1.0
HG13 B:ILE271 3.8 20.5 1.0
CD1 B:ILE46 3.8 20.7 1.0
CD1 A:ILE46 3.8 20.7 1.0
HG13 B:ILE46 3.9 20.7 1.0
HG13 A:ILE46 3.9 20.7 1.0
CD1 B:ILE271 4.0 20.5 1.0
CD1 A:ILE271 4.0 20.6 1.0
HD13 B:ILE271 4.0 20.5 1.0
HD13 A:ILE271 4.0 20.6 1.0
O A:HOH842 4.5 24.7 1.0
O B:HOH842 4.5 24.8 1.0
O A:HOH808 4.6 16.9 1.0
O B:HOH808 4.6 17.1 1.0
HG23 B:ILE46 4.6 20.7 1.0
HG23 A:ILE46 4.6 20.7 1.0
HG21 B:ILE46 4.6 20.7 1.0
HG21 A:ILE46 4.6 20.7 1.0
HD12 B:ILE46 4.7 20.7 1.0
HD12 A:ILE46 4.8 20.7 1.0
HA A:ILE271 4.8 20.6 1.0
CB B:ILE46 4.8 20.7 1.0
HA B:ILE271 4.8 20.5 1.0
CB A:ILE46 4.8 20.7 1.0
HA B:ILE46 4.9 20.7 1.0
HA A:ILE46 4.9 20.7 1.0
K A:K703 4.9 52.9 1.0
K B:K703 4.9 53.3 1.0
HG21 B:ILE271 4.9 20.5 1.0
HG21 A:ILE271 4.9 20.6 1.0
HD12 A:ILE271 4.9 20.6 1.0
HD12 B:ILE271 4.9 20.5 1.0
CB B:ILE271 4.9 20.5 1.0
CB A:ILE271 4.9 20.6 1.0
CG2 B:ILE46 4.9 20.7 1.0
CG2 A:ILE46 4.9 20.7 1.0

Potassium binding site 5 out of 7 in 6wc9

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Potassium binding site 5 out of 7 in the Human Open State TMEM175 in Kcl


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of Human Open State TMEM175 in Kcl within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K701

b:41.3
occ:1.00
 K A:K701 2.9 40.7 1.0
HB2 B:ALA263 3.2 18.8 1.0
HB3 B:SER38 3.2 20.4 1.0
HB1 B:ALA263 3.5 18.8 1.0
O B:HOH826 3.6 15.6 1.0
HG B:SER38 3.6 20.4 1.0
OG B:SER38 3.7 20.4 1.0
CB B:ALA263 3.8 18.8 1.0
CB B:SER38 3.9 20.4 1.0
O A:HOH811 3.9 23.3 1.0
O B:HOH812 4.0 23.2 1.0
HB3 A:SER38 4.0 20.4 1.0
O B:HOH843 4.0 20.3 1.0
O B:HOH846 4.0 22.4 1.0
HA B:SER38 4.1 20.4 1.0
HG A:SER38 4.2 20.4 1.0
HA B:ALA263 4.2 18.8 1.0
HB3 B:ALA263 4.5 18.8 1.0
O B:HOH807 4.6 20.0 1.0
O B:HOH847 4.6 26.9 1.0
CA B:SER38 4.6 20.4 1.0
CA B:ALA263 4.6 18.8 1.0
HB2 B:SER38 4.7 20.4 1.0
OG A:SER38 4.7 20.4 1.0
CB A:SER38 4.8 20.4 1.0
O A:HOH846 4.9 22.5 1.0

Potassium binding site 6 out of 7 in 6wc9

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Potassium binding site 6 out of 7 in the Human Open State TMEM175 in Kcl


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 6 of Human Open State TMEM175 in Kcl within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K702

b:43.7
occ:1.00
 O B:HOH816 2.7 19.8 1.0
K A:K702 2.8 42.7 1.0
HA2 B:GLY267 2.9 17.6 1.0
O B:HOH808 3.0 17.1 1.0
HA3 B:GLY267 3.1 17.6 1.0
O B:HOH842 3.1 24.8 1.0
HB1 A:ALA42 3.3 18.3 1.0
HA B:ALA42 3.4 18.2 1.0
CA B:GLY267 3.4 17.6 1.0
HB2 A:ALA42 3.5 18.3 1.0
HB2 B:ALA42 3.6 18.2 1.0
HB1 B:ALA42 3.7 18.2 1.0
CB A:ALA42 3.9 18.3 1.0
CB B:ALA42 4.0 18.2 1.0
N B:GLY267 4.0 17.6 1.0
H B:GLY267 4.1 17.6 1.0
CA B:ALA42 4.1 18.2 1.0
HG B:SER45 4.1 18.4 1.0
OG B:SER45 4.2 18.4 1.0
O A:HOH842 4.3 24.7 1.0
O B:HOH826 4.4 15.6 1.0
O B:HOH846 4.4 22.4 1.0
HB3 A:ALA42 4.5 18.3 1.0
O A:HOH808 4.6 16.9 1.0
HA A:ALA42 4.7 18.3 1.0
C B:GLY267 4.7 17.6 1.0
O B:ALA263 4.7 18.8 1.0
O A:HOH816 4.8 19.6 1.0
C B:ASP266 4.9 18.6 1.0
HB3 B:ALA42 4.9 18.2 1.0
CA A:ALA42 4.9 18.3 1.0
N B:ALA42 5.0 18.2 1.0

Potassium binding site 7 out of 7 in 6wc9

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Potassium binding site 7 out of 7 in the Human Open State TMEM175 in Kcl


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 7 of Human Open State TMEM175 in Kcl within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K703

b:53.3
occ:1.00
 O B:HOH850 2.8 25.6 1.0
O B:HOH852 2.8 26.0 1.0
O A:HOH853 2.8 33.8 1.0
O B:HOH853 2.8 34.1 1.0
K A:K703 3.3 52.9 1.0
HD13 B:LEU53 3.5 35.1 1.0
HD23 B:LEU278 3.6 30.0 1.0
HG23 B:ILE271 3.7 20.5 1.0
O B:HOH819 3.8 23.3 1.0
O B:HOH820 3.8 23.0 1.0
HD22 B:LEU278 3.8 30.0 1.0
HD21 B:LEU53 3.9 35.1 1.0
HD23 B:LEU275 3.9 27.6 1.0
HD21 A:LEU278 3.9 30.0 1.0
CD2 B:LEU278 4.0 30.0 1.0
HD21 B:LEU278 4.0 30.0 1.0
HD23 A:LEU278 4.0 30.0 1.0
O A:HOH852 4.0 25.7 1.0
HD21 B:LEU275 4.1 27.6 1.0
HG21 B:ILE271 4.1 20.5 1.0
CG2 B:ILE271 4.4 20.5 1.0
O A:HOH850 4.4 25.7 1.0
CD1 B:LEU53 4.4 35.1 1.0
CD2 A:LEU278 4.4 30.0 1.0
CD2 B:LEU275 4.5 27.6 1.0
HG12 B:ILE271 4.6 20.5 1.0
CD2 B:LEU53 4.7 35.1 1.0
HD12 B:LEU53 4.8 35.1 1.0
HG B:LEU275 4.9 27.6 1.0
HD11 B:LEU53 4.9 35.1 1.0
K A:K704 4.9 41.9 1.0
HD22 A:LEU278 4.9 30.0 1.0
HG22 B:ILE271 4.9 20.5 1.0
HG B:LEU53 5.0 35.1 1.0

Reference:

S.Oh, N.Paknejad, R.K.Hite. Gating and Selectivity Mechanisms For the Lysosomal K+Channel TMEM175. Elife V. 9 2020.
ISSN: ESSN 2050-084X
PubMed: 32228865
DOI: 10.7554/ELIFE.53430
Page generated: Sat Aug 9 12:37:08 2025

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