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Potassium in PDB 6w8c: K2P2.1 (Trek-1):ML335 Complex, 1 Mm K+

Protein crystallography data

The structure of K2P2.1 (Trek-1):ML335 Complex, 1 Mm K+, PDB code: 6w8c was solved by M.Lolicato, D.L.Minor, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 14.97 / 2.60
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 67.129, 119.783, 128.872, 90, 90, 90
R / Rfree (%) 25.1 / 26.3

Other elements in 6w8c:

The structure of K2P2.1 (Trek-1):ML335 Complex, 1 Mm K+ also contains other interesting chemical elements:

Chlorine (Cl) 4 atoms
Cadmium (Cd) 3 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the K2P2.1 (Trek-1):ML335 Complex, 1 Mm K+ (pdb code 6w8c). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 6 binding sites of Potassium where determined in the K2P2.1 (Trek-1):ML335 Complex, 1 Mm K+, PDB code: 6w8c:
Jump to Potassium binding site number: 1; 2; 3; 4; 5; 6;

Potassium binding site 1 out of 6 in 6w8c

Go back to Potassium Binding Sites List in 6w8c
Potassium binding site 1 out of 6 in the K2P2.1 (Trek-1):ML335 Complex, 1 Mm K+


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of K2P2.1 (Trek-1):ML335 Complex, 1 Mm K+ within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K401

b:127.8
occ:1.00
 OG1 A:THR142 4.1 68.2 1.0
OG1 A:THR251 4.7 77.8 1.0
K A:K412 4.8 91.5 1.0
OG1 B:THR251 4.9 76.4 1.0

Potassium binding site 2 out of 6 in 6w8c

Go back to Potassium Binding Sites List in 6w8c
Potassium binding site 2 out of 6 in the K2P2.1 (Trek-1):ML335 Complex, 1 Mm K+


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of K2P2.1 (Trek-1):ML335 Complex, 1 Mm K+ within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K402

b:96.1
occ:1.00
 O B:PHE145 2.9 82.9 1.0
O A:PHE254 3.0 74.4 1.0
O A:PHE145 3.0 73.5 1.0
O B:PHE254 3.0 81.5 1.0
O A:GLY253 3.3 69.1 1.0
O B:GLY253 3.3 81.3 1.0
O A:GLY144 3.4 72.8 1.0
O B:GLY144 3.4 76.6 1.0
C B:PHE145 3.5 83.9 1.0
C A:PHE145 3.5 73.6 1.0
K A:K403 3.6 119.3 1.0
C A:PHE254 3.7 73.1 1.0
C B:PHE254 3.7 80.9 1.0
CA A:PHE254 4.2 71.4 1.0
CA B:PHE254 4.2 78.7 1.0
CA B:PHE145 4.2 80.5 1.0
CA A:PHE145 4.2 71.2 1.0
N B:GLY146 4.2 84.7 1.0
N A:GLY146 4.2 75.6 1.0
CA A:GLY146 4.3 79.1 1.0
CA B:GLY146 4.3 85.8 1.0
C A:GLY253 4.3 69.0 1.0
C B:GLY253 4.4 80.1 1.0
C B:GLY144 4.4 77.2 1.0
C A:GLY144 4.4 73.0 1.0
N A:GLY255 4.5 73.3 1.0
N B:GLY255 4.5 81.2 1.0
N A:PHE254 4.7 69.9 1.0
N B:PHE254 4.7 79.4 1.0
N B:PHE145 4.7 79.3 1.0
N A:PHE145 4.8 71.7 1.0
CA A:GLY255 4.9 74.9 1.0
CA B:GLY255 4.9 82.0 1.0

Potassium binding site 3 out of 6 in 6w8c

Go back to Potassium Binding Sites List in 6w8c
Potassium binding site 3 out of 6 in the K2P2.1 (Trek-1):ML335 Complex, 1 Mm K+


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of K2P2.1 (Trek-1):ML335 Complex, 1 Mm K+ within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K403

b:119.3
occ:1.00
 O B:ILE252 2.8 83.0 1.0
K A:K404 2.9 87.1 1.0
O B:ILE143 3.0 73.0 1.0
O A:ILE252 3.0 69.6 1.0
O B:GLY253 3.1 81.3 1.0
O B:GLY144 3.2 76.6 1.0
O A:GLY144 3.3 72.8 1.0
O A:ILE143 3.3 76.7 1.0
O A:GLY253 3.4 69.1 1.0
K A:K402 3.6 96.1 1.0
C B:GLY253 3.7 80.1 1.0
C B:GLY144 3.7 77.2 1.0
C A:GLY144 3.8 73.0 1.0
C B:ILE252 3.9 81.5 1.0
C A:GLY253 4.0 69.0 1.0
C B:ILE143 4.0 73.4 1.0
CA B:GLY253 4.1 79.4 1.0
CA B:GLY144 4.1 75.7 1.0
C A:ILE252 4.2 69.4 1.0
CA A:GLY144 4.2 74.7 1.0
C A:ILE143 4.3 76.9 1.0
CA A:GLY253 4.4 68.2 1.0
N B:PHE145 4.4 79.3 1.0
N B:GLY253 4.4 80.2 1.0
N B:GLY144 4.5 74.3 1.0
N B:PHE254 4.5 79.4 1.0
N A:PHE145 4.7 71.7 1.0
N A:GLY144 4.7 76.0 1.0
O B:THR251 4.7 77.8 1.0
O B:THR142 4.7 69.8 1.0
N A:GLY253 4.8 68.6 1.0
N A:PHE254 4.8 69.9 1.0
O A:THR142 4.8 70.8 1.0
CA B:PHE145 4.8 80.5 1.0
O A:THR251 4.9 71.0 1.0

Potassium binding site 4 out of 6 in 6w8c

Go back to Potassium Binding Sites List in 6w8c
Potassium binding site 4 out of 6 in the K2P2.1 (Trek-1):ML335 Complex, 1 Mm K+


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of K2P2.1 (Trek-1):ML335 Complex, 1 Mm K+ within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K404

b:87.1
occ:1.00
 O A:THR251 2.7 71.0 1.0
O B:THR251 2.8 77.8 1.0
O B:THR142 2.8 69.8 1.0
K A:K403 2.9 119.3 1.0
O A:THR142 2.9 70.8 1.0
O A:ILE252 3.0 69.6 1.0
O B:ILE252 3.1 83.0 1.0
K A:K412 3.2 91.5 1.0
O A:ILE143 3.5 76.7 1.0
O B:ILE143 3.5 73.0 1.0
C A:ILE252 3.8 69.4 1.0
C A:THR251 3.9 71.5 1.0
C B:ILE252 3.9 81.5 1.0
C B:ILE143 3.9 73.4 1.0
C A:ILE143 4.0 76.9 1.0
C B:THR142 4.0 69.7 1.0
C B:THR251 4.0 76.9 1.0
C A:THR142 4.1 71.3 1.0
CA A:ILE252 4.2 69.7 1.0
CA A:ILE143 4.3 76.4 1.0
CA B:ILE143 4.3 72.7 1.0
CA B:ILE252 4.4 80.2 1.0
N A:ILE252 4.6 70.0 1.0
N B:ILE143 4.6 70.7 1.0
N B:GLY144 4.7 74.3 1.0
N A:GLY253 4.7 68.6 1.0
N A:ILE143 4.7 73.6 1.0
N B:ILE252 4.7 77.7 1.0
N A:GLY144 4.7 76.0 1.0
N B:GLY253 4.8 80.2 1.0
CA B:GLY144 4.9 75.7 1.0
CA A:GLY253 5.0 68.2 1.0
CB A:THR251 5.0 75.1 1.0
CA A:GLY144 5.0 74.7 1.0
CA A:THR251 5.0 72.9 1.0

Potassium binding site 5 out of 6 in 6w8c

Go back to Potassium Binding Sites List in 6w8c
Potassium binding site 5 out of 6 in the K2P2.1 (Trek-1):ML335 Complex, 1 Mm K+


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of K2P2.1 (Trek-1):ML335 Complex, 1 Mm K+ within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K412

b:91.5
occ:1.00
 OG1 A:THR251 2.9 77.8 1.0
OG1 B:THR142 3.0 70.6 1.0
OG1 B:THR251 3.1 76.4 1.0
O A:THR251 3.1 71.0 1.0
OG1 A:THR142 3.1 68.2 1.0
K A:K404 3.2 87.1 1.0
O B:THR251 3.3 77.8 1.0
O B:THR142 3.4 69.8 1.0
O A:THR142 3.5 70.8 1.0
CB A:THR251 3.5 75.1 1.0
CB B:THR251 3.7 75.0 1.0
CB B:THR142 3.7 69.3 1.0
CB A:THR142 3.9 67.9 1.0
C A:THR251 3.9 71.5 1.0
C B:THR142 4.1 69.7 1.0
C B:THR251 4.1 76.9 1.0
C A:THR142 4.2 71.3 1.0
CA A:THR251 4.4 72.9 1.0
CA B:THR142 4.6 68.7 1.0
CA B:THR251 4.6 74.9 1.0
CG2 A:THR251 4.7 74.9 1.0
CA A:THR142 4.7 69.2 1.0
CG2 B:THR251 4.8 74.4 1.0
K A:K401 4.8 127.8 1.0
CG2 B:THR142 4.9 69.6 1.0
N A:ILE252 4.9 70.0 1.0
N B:ILE143 4.9 70.7 1.0
O A:THR250 5.0 75.8 1.0

Potassium binding site 6 out of 6 in 6w8c

Go back to Potassium Binding Sites List in 6w8c
Potassium binding site 6 out of 6 in the K2P2.1 (Trek-1):ML335 Complex, 1 Mm K+


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 6 of K2P2.1 (Trek-1):ML335 Complex, 1 Mm K+ within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K401

b:157.7
occ:1.00
 N B:ASN147 4.1 86.8 1.0
O B:PHE145 4.1 82.9 1.0
O B:GLY255 4.2 83.2 1.0
C B:GLY146 4.2 86.5 1.0
O B:PHE254 4.3 81.5 1.0
CA B:ASN147 4.4 87.3 1.0
O B:GLY146 4.4 86.0 1.0
C B:GLY255 4.5 83.3 1.0
CA B:GLY255 4.6 82.0 1.0
CA B:GLY146 4.8 85.8 1.0

Reference:

M.Lolicato, A.M.Natale, F.Abderemane-Ali, D.Crottes, S.Capponi, R.Duman, A.Wagner, J.M.Rosenberg, M.Grabe, D.L.Minor Jr.. K 2P Channel C-Type Gating Involves Asymmetric Selectivity Filter Order-Disorder Transitions. Sci Adv V. 6 2020.
ISSN: ESSN 2375-2548
PubMed: 33127683
DOI: 10.1126/SCIADV.ABC9174
Page generated: Sat Aug 9 12:34:38 2025

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