Potassium in PDB 6t4c: Bovine Enterovirus F3 in Complex with Glutathione

All present enzymatic activity of Bovine Enterovirus F3 in Complex with Glutathione:
2.7.7.48; 3.4.22.28; 3.4.22.29; 3.6.1.15;

The structure of Bovine Enterovirus F3 in Complex with Glutathione, PDB code: 6t4c was solved by H.M.E.Duyvesteyn, J.Ren, T.S.Walter, E.E.Fry, D.I.Stuart, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.98 / 1.80
Space group	I 2 2 2
Cell size a, b, c (Å), α, β, γ (°)	342.750, 348.160, 351.420, 90.00, 90.00, 90.00
R / Rfree (%)	20.5 / 20.8

The binding sites of Potassium atom in the Bovine Enterovirus F3 in Complex with Glutathione (pdb code 6t4c). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 4 binding sites of Potassium where determined in the Bovine Enterovirus F3 in Complex with Glutathione, PDB code: 6t4c:
Jump to Potassium binding site number: 1; 2; 3; 4;

Potassium binding site 1 out of 4 in the Bovine Enterovirus F3 in Complex with Glutathione


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Bovine Enterovirus F3 in Complex with Glutathione within 5.0Å range: probe atom residue distance (Å) B Occ A:K306 b:26.3 occ:1.00 O A:VAL15 2.9 17.2 1.0 O A:ASN57 2.9 18.9 1.0 OD1 A:ASN17 2.9 20.7 1.0 OG1 A:THR14 3.0 23.5 1.0 CG A:ASN17 3.6 22.8 1.0 CB A:THR14 3.8 21.5 1.0 O A:HOH526 3.9 27.5 1.0 ND2 A:ASN17 3.9 21.6 1.0 C A:ASN57 4.0 20.4 1.0 N A:ASN17 4.1 15.6 1.0 C A:VAL15 4.1 19.9 1.0 C A:GLU16 4.5 17.1 1.0 C A:THR14 4.6 20.1 1.0 CB A:ASN17 4.6 15.1 1.0 CA A:ASN17 4.6 13.9 1.0 N A:ASN57 4.6 15.9 1.0 CA A:GLU16 4.6 16.4 1.0 O A:HOH421 4.7 36.5 1.0 CA A:ASN57 4.7 18.3 1.0 O A:HOH565 4.7 37.7 1.0 N A:VAL15 4.7 15.8 1.0 CG2 A:THR14 4.7 21.9 1.0 CB A:ASN57 4.7 15.9 1.0 O A:THR14 4.8 16.5 1.0 N A:GLU16 4.9 17.2 1.0 CA A:THR14 4.9 15.6 1.0 N A:THR58 5.0 17.1 1.0

Potassium binding site 2 out of 4 in the Bovine Enterovirus F3 in Complex with Glutathione


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Bovine Enterovirus F3 in Complex with Glutathione within 5.0Å range: probe atom residue distance (Å) B Occ A:K307 b:30.2 occ:1.00 O A:LEU33 2.8 16.9 1.0 O D:ALA65 2.9 26.8 1.0 O D:GLU63 2.9 22.6 1.0 O A:HOH588 3.1 30.2 1.0 O A:THR30 3.2 18.3 1.0 O A:PRO31 3.3 17.9 1.0 NE2 A:GLN34 3.4 18.2 1.0 C A:PRO31 3.8 19.3 1.0 CA A:PRO31 3.8 18.1 1.0 C D:GLU63 3.8 22.9 1.0 C A:LEU33 4.0 19.4 1.0 C A:THR30 4.1 18.3 1.0 C D:ALA65 4.1 28.1 1.0 OD1 A:ASN43 4.1 19.8 1.0 O D:LYS62 4.2 19.0 1.0 CD A:GLN34 4.3 20.2 1.0 CA D:GLU63 4.3 24.3 1.0 N A:PRO31 4.4 17.2 1.0 O D:HOH105 4.4 32.0 1.0 CD D:PRO67 4.4 19.3 1.0 N A:LEU33 4.4 17.7 1.0 CG D:PRO67 4.5 24.7 1.0 N D:ALA65 4.6 27.1 1.0 CA A:LEU33 4.7 18.6 1.0 N A:ALA32 4.8 14.2 1.0 CA D:VAL66 4.8 21.4 1.0 OE1 A:GLN34 4.9 19.1 1.0 CB A:LEU33 4.9 14.8 1.0 N D:ALA64 4.9 17.6 1.0 OG1 A:THR30 4.9 23.6 1.0 C D:ALA64 4.9 25.0 1.0 N D:VAL66 4.9 21.5 1.0 N D:PRO67 5.0 21.5 1.0 CA D:ALA65 5.0 21.9 1.0

Potassium binding site 3 out of 4 in the Bovine Enterovirus F3 in Complex with Glutathione


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Bovine Enterovirus F3 in Complex with Glutathione within 5.0Å range: probe atom residue distance (Å) B Occ B:K302 b:56.5 occ:1.00 O B:GLN53 3.1 18.7 1.0 O B:HOH584 3.9 43.6 1.0 C B:GLN53 4.2 18.0 1.0 N B:GLY55 4.5 15.2 1.0 C B:PRO54 4.7 17.5 1.0 CA B:GLY55 4.7 15.4 1.0 CB B:GLN53 4.7 18.5 1.0 O B:PRO54 4.9 18.5 1.0 O B:HOH588 4.9 31.8 1.0

Potassium binding site 4 out of 4 in the Bovine Enterovirus F3 in Complex with Glutathione


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Bovine Enterovirus F3 in Complex with Glutathione within 5.0Å range: probe atom residue distance (Å) B Occ C:K405 b:27.4 occ:1.00 O A:SER42 2.9 16.1 1.0 OE1 C:GLN222 2.9 15.9 1.0 O C:HOH507 3.0 17.8 1.0 O A:HOH454 3.0 18.4 1.0 O A:HOH612 3.2 33.9 1.0 OD2 C:ASP114 3.3 17.7 1.0 CB C:ASP114 3.7 14.1 1.0 CG C:ASP114 3.7 20.2 1.0 CG2 A:THR41 3.8 16.3 1.0 C A:SER42 3.9 20.3 1.0 CD C:GLN222 4.1 22.9 1.0 O C:HOH566 4.2 19.8 1.0 O A:HOH519 4.3 40.0 1.0 CB A:SER42 4.5 16.2 1.0 CA A:SER42 4.6 15.4 1.0 O C:ALA221 4.6 14.1 1.0 O A:ALA44 4.6 18.8 1.0 N A:SER42 4.7 13.9 1.0 OD1 C:ASP114 4.7 16.8 1.0 NE2 C:GLN222 4.7 14.9 1.0 OG A:SER42 4.8 15.4 1.0 N A:ASN43 4.8 15.9 1.0 CA A:ASN43 4.9 18.4 1.0 OE2 C:GLU50 4.9 17.8 1.0 O C:GLN48 5.0 14.0 1.0

H.M.E.Duyvesteyn, J.Ren, T.S.Walter, E.E.Fry, D.I.Stuart. Glutathione Facilitates Enterovirus Assembly By Binding at A Druggable Pocket. Commun Biol V. 3 9 2020.
ISSN: ESSN 2399-3642
PubMed: 31909201
DOI: 10.1038/S42003-019-0722-X