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Potassium in PDB 6rv4: Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237

Protein crystallography data

The structure of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237, PDB code: 6rv4 was solved by K.E.J.Rodstrom, A.C.W.Pike, W.Zhang, A.Quigley, D.Speedman, S.M.M.Mukhopadhyay, L.Shrestha, R.Chalk, S.Venkaya, S.R.Bushell, A.Tessitore, N.Burgess-Brown, C.H.Arrowsmith, A.M.Edwards, C.Bountra, E.P.Carpenter, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 41.16 / 3.10
Space group P 2 21 21
Cell size a, b, c (Å), α, β, γ (°) 45.100, 201.330, 238.570, 90.00, 90.00, 90.00
R / Rfree (%) 25 / 25.6

Other elements in 6rv4:

The structure of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237 also contains other interesting chemical elements:

Fluorine (F) 6 atoms
Chlorine (Cl) 2 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237 (pdb code 6rv4). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 8 binding sites of Potassium where determined in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237, PDB code: 6rv4:
Jump to Potassium binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Potassium binding site 1 out of 8 in 6rv4

Go back to Potassium Binding Sites List in 6rv4
Potassium binding site 1 out of 8 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K302

b:49.5
occ:1.00
 O A:GLY201 2.6 18.2 1.0
O A:ILE94 2.7 22.0 1.0
O A:ILE200 2.7 17.2 1.0
O A:GLY95 2.7 24.9 1.0
O B:GLY201 2.8 22.8 1.0
O B:ILE94 2.8 17.6 1.0
O B:GLY95 2.8 20.1 1.0
K A:K303 2.8 32.5 1.0
O B:ILE200 2.8 19.5 1.0
K A:K309 3.0 19.9 1.0
C A:GLY201 3.5 18.5 1.0
C A:GLY95 3.6 25.3 1.0
C B:GLY95 3.6 20.3 1.0
C B:GLY201 3.6 23.5 1.0
C A:ILE200 3.8 16.7 1.0
C A:ILE94 3.8 22.8 1.0
C B:ILE94 3.9 17.8 1.0
C B:ILE200 3.9 19.7 1.0
CA A:GLY201 4.0 13.3 1.0
CA A:GLY95 4.2 20.4 1.0
CA B:GLY201 4.2 18.2 1.0
CA B:GLY95 4.2 14.8 1.0
N A:GLY201 4.3 13.0 1.0
N A:GLY95 4.4 20.1 1.0
N B:GLY201 4.5 17.7 1.0
N A:TYR96 4.5 22.4 1.0
N B:GLY95 4.5 14.4 1.0
N A:PHE202 4.5 16.0 1.0
N B:TYR96 4.6 17.6 1.0
N B:PHE202 4.6 21.4 1.0
CA A:TYR96 4.8 22.6 1.0
O A:THR199 4.9 15.8 1.0
CA A:PHE202 4.9 16.1 1.0
CA B:TYR96 4.9 17.3 1.0
O A:THR93 4.9 23.1 1.0
O B:THR93 4.9 17.6 1.0
O B:THR199 4.9 14.8 1.0
CA B:PHE202 5.0 21.8 1.0

Potassium binding site 2 out of 8 in 6rv4

Go back to Potassium Binding Sites List in 6rv4
Potassium binding site 2 out of 8 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K303

b:32.5
occ:1.00
 O B:THR93 2.7 17.6 1.0
O A:THR199 2.7 15.8 1.0
O B:THR199 2.7 14.8 1.0
O A:THR93 2.7 23.1 1.0
O B:ILE94 2.7 17.6 1.0
O A:ILE94 2.7 22.0 1.0
K A:K302 2.8 49.5 1.0
O B:ILE200 2.8 19.5 1.0
O A:ILE200 2.8 17.2 1.0
C B:ILE94 3.5 17.8 1.0
C A:ILE94 3.5 22.8 1.0
C B:ILE200 3.6 19.7 1.0
C A:ILE200 3.6 16.7 1.0
K A:K304 3.6 20.9 1.0
C A:THR199 3.8 16.3 1.0
C B:THR93 3.8 17.8 1.0
C B:THR199 3.8 16.1 1.0
C A:THR93 3.8 23.3 1.0
CA B:ILE94 4.0 13.4 1.0
CA A:ILE94 4.0 18.0 1.0
CA A:ILE200 4.1 11.3 1.0
CA B:ILE200 4.1 14.1 1.0
N A:ILE200 4.4 11.8 1.0
N B:ILE200 4.4 13.9 1.0
N B:ILE94 4.4 13.7 1.0
N A:ILE94 4.4 18.6 1.0
N B:GLY201 4.5 17.7 1.0
N A:GLY201 4.5 13.0 1.0
N A:GLY95 4.5 20.1 1.0
N B:GLY95 4.5 14.4 1.0
O B:GLY201 4.8 22.8 1.0
O A:GLY201 4.8 18.2 1.0
O A:GLY95 4.8 24.9 1.0
O B:GLY95 4.8 20.1 1.0
CA B:GLY201 4.9 18.2 1.0
CA A:GLY201 4.9 13.3 1.0
CA A:GLY95 5.0 20.4 1.0
CA B:GLY95 5.0 14.8 1.0

Potassium binding site 3 out of 8 in 6rv4

Go back to Potassium Binding Sites List in 6rv4
Potassium binding site 3 out of 8 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K304

b:20.9
occ:1.00
 OG1 B:THR93 2.8 15.4 1.0
OG1 A:THR93 2.8 28.4 1.0
O A:THR199 2.8 15.8 1.0
OG1 A:THR199 2.8 22.0 1.0
O A:THR93 2.9 23.1 1.0
O B:THR93 2.9 17.6 1.0
O B:THR199 2.9 14.8 1.0
OG1 B:THR199 3.0 16.6 1.0
CB B:THR93 3.3 17.5 1.0
CB A:THR93 3.3 27.6 1.0
CB A:THR199 3.4 22.1 1.0
CB B:THR199 3.5 17.7 1.0
K A:K303 3.6 32.5 1.0
C A:THR199 3.7 16.3 1.0
C A:THR93 3.7 23.3 1.0
C B:THR93 3.7 17.8 1.0
C B:THR199 3.8 16.1 1.0
C2 A:KKZ307 3.9 45.5 1.0
CA B:THR93 4.1 14.2 1.0
CA A:THR93 4.2 20.5 1.0
CA A:THR199 4.2 13.7 1.0
CA B:THR199 4.3 11.7 1.0
CG2 B:THR93 4.4 14.5 1.0
N1 A:KKZ307 4.5 45.2 1.0
CG2 A:THR93 4.5 26.1 1.0
CG2 A:THR199 4.6 20.7 1.0
CG2 B:THR199 4.7 14.7 1.0
N A:ILE200 4.8 11.8 1.0
N A:ILE94 4.8 18.6 1.0
N B:ILE94 4.8 13.7 1.0
N B:ILE200 4.9 13.9 1.0
O A:THR92 5.0 25.5 1.0
O A:THR198 5.0 17.7 1.0

Potassium binding site 4 out of 8 in 6rv4

Go back to Potassium Binding Sites List in 6rv4
Potassium binding site 4 out of 8 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K309

b:19.9
occ:1.00
 O B:GLY201 2.7 22.8 1.0
O B:PHE202 2.8 27.7 1.0
O A:GLY201 2.8 18.2 1.0
O A:GLY95 2.8 24.9 1.0
O A:TYR96 2.8 29.4 1.0
O B:GLY95 2.8 20.1 1.0
O B:TYR96 2.9 22.1 1.0
O A:PHE202 2.9 21.2 1.0
K A:K302 3.0 49.5 1.0
C A:TYR96 3.4 29.6 1.0
C B:TYR96 3.4 22.3 1.0
C B:PHE202 3.4 27.4 1.0
C A:PHE202 3.6 21.1 1.0
C B:GLY201 3.8 23.5 1.0
CA B:TYR96 3.8 17.3 1.0
CA A:TYR96 3.8 22.6 1.0
C A:GLY95 3.9 25.3 1.0
CA B:PHE202 3.9 21.8 1.0
C B:GLY95 3.9 20.3 1.0
C A:GLY201 3.9 18.5 1.0
CA A:PHE202 4.0 16.1 1.0
N A:GLY97 4.2 28.1 1.0
N B:GLY97 4.3 19.8 1.0
N A:TYR96 4.3 22.4 1.0
N B:PHE202 4.3 21.4 1.0
N B:TYR96 4.3 17.6 1.0
N B:GLY203 4.4 24.6 1.0
N A:PHE202 4.4 16.0 1.0
N A:GLY203 4.5 18.1 1.0
CA A:GLY97 4.7 28.9 1.0
CA B:GLY97 4.8 20.4 1.0
CA B:GLY203 4.8 24.8 1.0
O B:ILE200 4.9 19.5 1.0
O B:ILE94 4.9 17.6 1.0
O A:ILE94 4.9 22.0 1.0
CA A:GLY203 4.9 18.2 1.0
O A:ILE200 4.9 17.2 1.0

Potassium binding site 5 out of 8 in 6rv4

Go back to Potassium Binding Sites List in 6rv4
Potassium binding site 5 out of 8 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K302

b:0.5
occ:1.00
 O C:GLY201 2.6 30.3 1.0
O C:ILE94 2.7 21.2 1.0
O C:ILE200 2.7 30.0 1.0
O D:GLY95 2.7 22.1 1.0
O C:GLY95 2.7 24.6 1.0
O D:GLY201 2.7 32.1 1.0
O D:ILE94 2.8 21.6 1.0
K C:K303 2.8 10.2 1.0
O D:ILE200 2.8 31.7 1.0
K C:K307 3.0 25.3 1.0
C C:GLY201 3.5 30.6 1.0
C C:GLY95 3.6 25.1 1.0
C D:GLY95 3.6 22.8 1.0
C D:GLY201 3.6 32.7 1.0
C C:ILE200 3.8 29.9 1.0
C C:ILE94 3.8 21.4 1.0
C D:ILE94 3.9 21.5 1.0
C D:ILE200 3.9 31.8 1.0
CA C:GLY201 4.1 26.3 1.0
CA C:GLY95 4.2 19.4 1.0
CA D:GLY201 4.2 28.7 1.0
CA D:GLY95 4.2 18.2 1.0
N C:GLY201 4.3 26.3 1.0
N C:GLY95 4.4 19.0 1.0
N D:GLY95 4.5 18.1 1.0
N C:TYR96 4.5 23.7 1.0
N D:GLY201 4.5 28.8 1.0
N C:PHE202 4.5 27.2 1.0
N D:TYR96 4.5 20.3 1.0
N D:PHE202 4.6 29.5 1.0
CA C:TYR96 4.8 24.5 1.0
CA D:TYR96 4.9 20.6 1.0
CA C:PHE202 4.9 27.1 1.0
O C:THR199 4.9 29.4 1.0
O C:THR93 4.9 17.9 1.0
O D:THR93 4.9 20.1 1.0
CA D:PHE202 5.0 29.1 1.0
O D:THR199 5.0 31.5 1.0

Potassium binding site 6 out of 8 in 6rv4

Go back to Potassium Binding Sites List in 6rv4
Potassium binding site 6 out of 8 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 6 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K303

b:10.2
occ:1.00
 O C:THR93 2.7 17.9 1.0
O C:THR199 2.7 29.4 1.0
O C:ILE94 2.7 21.2 1.0
O D:THR93 2.7 20.1 1.0
O D:THR199 2.7 31.5 1.0
O D:ILE94 2.8 21.6 1.0
K C:K302 2.8 0.5 1.0
O C:ILE200 2.8 30.0 1.0
O D:ILE200 2.8 31.7 1.0
C C:ILE94 3.5 21.4 1.0
C C:ILE200 3.5 29.9 1.0
C D:ILE94 3.6 21.5 1.0
K C:K304 3.6 39.6 1.0
C D:ILE200 3.6 31.8 1.0
C C:THR93 3.8 18.9 1.0
C C:THR199 3.8 29.4 1.0
C D:THR93 3.9 20.6 1.0
C D:THR199 3.9 31.6 1.0
CA C:ILE94 4.0 15.8 1.0
CA C:ILE200 4.1 25.4 1.0
CA D:ILE200 4.1 26.8 1.0
CA D:ILE94 4.1 16.6 1.0
N C:ILE94 4.4 16.1 1.0
N C:ILE200 4.4 25.7 1.0
N D:ILE200 4.4 27.4 1.0
N D:ILE94 4.4 17.0 1.0
N C:GLY201 4.4 26.3 1.0
N C:GLY95 4.5 19.0 1.0
N D:GLY201 4.5 28.8 1.0
N D:GLY95 4.5 18.1 1.0
O C:GLY201 4.8 30.3 1.0
O D:GLY95 4.8 22.1 1.0
O D:GLY201 4.8 32.1 1.0
O C:GLY95 4.8 24.6 1.0
CA C:GLY201 4.9 26.3 1.0
CA D:GLY201 4.9 28.7 1.0
CA C:GLY95 4.9 19.4 1.0
CA D:GLY95 5.0 18.2 1.0

Potassium binding site 7 out of 8 in 6rv4

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Potassium binding site 7 out of 8 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 7 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K304

b:39.6
occ:1.00
 OG1 D:THR93 2.8 19.1 1.0
OG1 C:THR93 2.8 18.2 1.0
O C:THR199 2.8 29.4 1.0
O D:THR93 2.8 20.1 1.0
O C:THR93 2.9 17.9 1.0
OG1 C:THR199 2.9 27.7 1.0
O D:THR199 2.9 31.5 1.0
OG1 D:THR199 3.0 34.0 1.0
CB D:THR93 3.2 22.4 1.0
CB C:THR93 3.3 21.1 1.0
CB C:THR199 3.4 30.0 1.0
CB D:THR199 3.5 33.6 1.0
K C:K303 3.6 10.2 1.0
C D:THR93 3.7 20.6 1.0
C C:THR199 3.7 29.4 1.0
C C:THR93 3.7 18.9 1.0
C D:THR199 3.8 31.6 1.0
C2 D:KKZ302 3.9 76.0 1.0
CA D:THR93 4.1 17.0 1.0
CA C:THR93 4.1 15.2 1.0
CA C:THR199 4.2 25.1 1.0
CA D:THR199 4.3 28.3 1.0
CG2 D:THR93 4.4 21.1 1.0
CG2 C:THR93 4.5 20.6 1.0
N1 D:KKZ302 4.5 75.0 1.0
CG2 C:THR199 4.6 28.5 1.0
CG2 D:THR199 4.7 30.6 1.0
N C:ILE200 4.8 25.7 1.0
N C:ILE94 4.8 16.1 1.0
N D:ILE94 4.8 17.0 1.0
N D:ILE200 4.9 27.4 1.0
O C:THR92 5.0 19.5 1.0

Potassium binding site 8 out of 8 in 6rv4

Go back to Potassium Binding Sites List in 6rv4
Potassium binding site 8 out of 8 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 8 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K307

b:25.3
occ:1.00
 O C:GLY201 2.8 30.3 1.0
O D:GLY201 2.8 32.1 1.0
O D:PHE202 2.8 33.5 1.0
O C:GLY95 2.8 24.6 1.0
O C:TYR96 2.8 29.4 1.0
O C:PHE202 2.8 32.4 1.0
O D:TYR96 2.8 25.2 1.0
O D:GLY95 2.9 22.1 1.0
K C:K302 3.0 0.5 1.0
C C:TYR96 3.4 29.8 1.0
C D:TYR96 3.4 25.4 1.0
C D:PHE202 3.5 33.8 1.0
C C:PHE202 3.5 32.7 1.0
CA C:TYR96 3.8 24.5 1.0
CA D:TYR96 3.9 20.6 1.0
C C:GLY95 3.9 25.1 1.0
C C:GLY201 3.9 30.6 1.0
C D:GLY201 3.9 32.7 1.0
C D:GLY95 3.9 22.8 1.0
CA D:PHE202 4.0 29.1 1.0
CA C:PHE202 4.0 27.1 1.0
N C:GLY97 4.2 27.5 1.0
N D:GLY97 4.3 22.5 1.0
N C:TYR96 4.3 23.7 1.0
N D:TYR96 4.3 20.3 1.0
N D:PHE202 4.4 29.5 1.0
N C:PHE202 4.4 27.2 1.0
N D:GLY203 4.4 30.8 1.0
N C:GLY203 4.4 30.2 1.0
CA C:GLY97 4.7 27.9 1.0
CA D:GLY97 4.7 22.8 1.0
CA D:GLY203 4.9 31.1 1.0
CA C:GLY203 4.9 30.5 1.0
O C:ILE94 4.9 21.2 1.0
O D:ILE200 4.9 31.7 1.0
O C:ILE200 4.9 30.0 1.0
O D:ILE94 5.0 21.6 1.0

Reference:

K.E.J.Rodstrom, A.K.Kiper, W.Zhang, S.Rinne, A.C.W.Pike, M.Goldstein, L.Conrad, M.Delbeck, M.Hahn, H.Meier, M.Platzk, A.Quigley, D.Speedman, L.Shrestha, S.M.M.Mukhopadhyay, N.A.Burgess-Brown, S.J.Tucker, T.Mueller, N.Decher, E.P.Carpenter. A Unique Lower X-Gate in Task Channels Sequesters Inhibitors Within the Vestibule To Be Published.
Page generated: Mon Aug 12 17:30:53 2024

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