Potassium in PDB 6c9u: Crystal Structure of [KS3][AT3] Didomain From Module 3 of 6- Deoxyerthronolide B Synthase in Complex with Antibody Fragment (Fab)

Enzymatic activity of Crystal Structure of [KS3][AT3] Didomain From Module 3 of 6- Deoxyerthronolide B Synthase in Complex with Antibody Fragment (Fab)

All present enzymatic activity of Crystal Structure of [KS3][AT3] Didomain From Module 3 of 6- Deoxyerthronolide B Synthase in Complex with Antibody Fragment (Fab):
2.3.1.94;

Protein crystallography data

The structure of Crystal Structure of [KS3][AT3] Didomain From Module 3 of 6- Deoxyerthronolide B Synthase in Complex with Antibody Fragment (Fab), PDB code: 6c9u was solved by L.N.Deis, X.Li, I.I.Mathews, C.Khosla, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	46.08 / 2.09
*Space group*	C 1 2 1
*Cell size a, b, c (Å), α, β, γ (°)*	115.768, 139.684, 102.580, 90.00, 97.05, 90.00
*R / R_free (%)*	16.6 / 21

Other elements in 6c9u:

The structure of Crystal Structure of [KS3][AT3] Didomain From Module 3 of 6- Deoxyerthronolide B Synthase in Complex with Antibody Fragment (Fab) also contains other interesting chemical elements:

Sodium

(Na)

2 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the Crystal Structure of [KS3][AT3] Didomain From Module 3 of 6- Deoxyerthronolide B Synthase in Complex with Antibody Fragment (Fab) (pdb code 6c9u). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Crystal Structure of [KS3][AT3] Didomain From Module 3 of 6- Deoxyerthronolide B Synthase in Complex with Antibody Fragment (Fab), PDB code: 6c9u:

Potassium binding site 1 out of 1 in 6c9u

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Potassium Binding Sites List in 6c9u

Potassium binding site 1 out of 1 in the Crystal Structure of [KS3][AT3] Didomain From Module 3 of 6- Deoxyerthronolide B Synthase in Complex with Antibody Fragment (Fab)

Mono view

Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of [KS3][AT3] Didomain From Module 3 of 6- Deoxyerthronolide B Synthase in Complex with Antibody Fragment (Fab) within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:K1001 b:37.1 occ:1.00	O	A:HOH1495	2.6	32.6	1.0
	O	A:LEU306	2.6	36.1	1.0
	OD2	A:ASP300	2.8	32.3	1.0
	O	A:ALA308	2.8	33.5	1.0
	OG	A:SER303	2.8	31.2	1.0
	HB2	A:ASP300	3.1	29.0	1.0
	O	A:HOH1286	3.1	30.2	1.0
	HA2	A:GLY447	3.4	30.9	1.0
	HA3	A:GLY447	3.6	30.9	1.0
	C	A:LEU306	3.6	37.3	1.0
	CB	A:ASP300	3.6	24.2	1.0
	HB3	A:SER303	3.7	37.4	1.0
	CG	A:ASP300	3.7	35.0	1.0
	HB3	A:ASP300	3.7	29.0	1.0
	CB	A:SER303	3.7	31.2	1.0
	HA	A:SER307	3.7	58.6	1.0
	H	A:ALA308	3.8	39.7	1.0
	O	A:GLY305	3.8	35.8	1.0
	C	A:ALA308	3.8	38.2	1.0
	N	A:ALA308	3.9	33.1	1.0
	HB2	A:SER303	3.9	37.4	1.0
	CA	A:GLY447	3.9	25.8	1.0
	C	A:SER307	4.1	37.6	1.0
	CA	A:SER307	4.2	48.8	1.0
	N	A:SER307	4.3	32.4	1.0
	HA	A:PRO309	4.4	49.7	1.0
	HA	A:LEU306	4.4	42.9	1.0
	N	A:GLY447	4.5	29.9	1.0
	CA	A:ALA308	4.5	43.1	1.0
	CA	A:LEU306	4.6	35.8	1.0
	HD12	A:LEU306	4.7	45.4	1.0
	H	A:SER303	4.7	42.4	1.0
	H	A:GLY447	4.7	35.8	1.0
	N	A:PRO309	4.8	35.9	1.0
	O	A:SER307	4.8	36.3	1.0
	HB3	A:ALA308	4.8	45.9	1.0
	O	A:ILE445	4.8	35.9	1.0
	O	A:GLY301	4.8	21.7	1.0
	OD1	A:ASP300	4.9	35.4	1.0
	C	A:GLY305	4.9	32.0	1.0
	CA	A:PRO309	5.0	41.4	1.0

Reference:

X.Li, N.Sevillano, F.La Greca, L.Deis, Y.C.Liu, M.C.Deller, I.I.Mathews, T.Matsui, D.E.Cane, C.S.Craik, C.Khosla. Structure-Function Analysis of the Extended Conformation of A Polyketide Synthase Module. J. Am. Chem. Soc. V. 140 6518 2018.
ISSN: ESSN 1520-5126
PubMed: 29762030
DOI: 10.1021/JACS.8B02100

Page generated: Mon Aug 12 15:30:56 2024

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