Potassium in PDB 5osx: Translation Initiation Factor 4E in Complex with M7G(5'S)Ppp(5'S)G Mrna 5' Cap Analog

The structure of Translation Initiation Factor 4E in Complex with M7G(5'S)Ppp(5'S)G Mrna 5' Cap Analog, PDB code: 5osx was solved by M.Warminski, E.Nowak, B.A.Wojtczak, K.Fac-Dabrowska, D.Kubacka, A.Nowicka, P.J.Sikorski, J.Kowalska, J.Jemielity, M.Nowotny, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.41 / 1.92
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	37.843, 37.855, 145.987, 86.56, 84.56, 77.05
R / Rfree (%)	22.4 / 26.9

The binding sites of Potassium atom in the Translation Initiation Factor 4E in Complex with M7G(5'S)Ppp(5'S)G Mrna 5' Cap Analog (pdb code 5osx). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Translation Initiation Factor 4E in Complex with M7G(5'S)Ppp(5'S)G Mrna 5' Cap Analog, PDB code: 5osx:

Potassium binding site 1 out of 1 in the Translation Initiation Factor 4E in Complex with M7G(5'S)Ppp(5'S)G Mrna 5' Cap Analog


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Translation Initiation Factor 4E in Complex with M7G(5'S)Ppp(5'S)G Mrna 5' Cap Analog within 5.0Å range: probe atom residue distance (Å) B Occ B:K302 b:64.7 occ:1.00 OE1 B:GLU99 2.7 73.5 1.0 O B:HOH417 3.9 57.4 1.0 CD B:GLU99 4.0 64.0 1.0 CZ3 B:TRP46 4.4 44.3 1.0 CH2 B:TRP46 4.4 36.9 1.0 OE2 B:GLU99 4.7 66.8 1.0 CG B:GLU99 4.9 50.2 1.0

B.A.Wojtczak, P.J.Sikorski, K.Fac-Dabrowska, A.Nowicka, M.Warminski, D.Kubacka, E.Nowak, M.Nowotny, J.Kowalska, J.Jemielity. 5'-Phosphorothiolate Dinucleotide Cap Analogues: Reagents For Messenger Rna Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes. J. Am. Chem. Soc. V. 140 5987 2018.
ISSN: ESSN 1520-5126
PubMed: 29676910
DOI: 10.1021/JACS.8B02597