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Potassium in PDB 4xdk: Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with Norfluoxetine

Protein crystallography data

The structure of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with Norfluoxetine, PDB code: 4xdk was solved by A.C.W.Pike, Y.Y.Dong, A.Mackenzie, S.Mukhopadhyay, C.H.Arrowsmith, A.M.Edwards, C.Bountra, N.A.Burgess-Brown, E.P.Carpenter, Structuralgenomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.87 / 3.60
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 75.190, 113.030, 112.500, 90.00, 90.41, 90.00
R / Rfree (%) 24.8 / 25.4

Other elements in 4xdk:

The structure of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with Norfluoxetine also contains other interesting chemical elements:

Fluorine (F) 24 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with Norfluoxetine (pdb code 4xdk). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 6 binding sites of Potassium where determined in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with Norfluoxetine, PDB code: 4xdk:
Jump to Potassium binding site number: 1; 2; 3; 4; 5; 6;

Potassium binding site 1 out of 6 in 4xdk

Go back to Potassium Binding Sites List in 4xdk
Potassium binding site 1 out of 6 in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with Norfluoxetine


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with Norfluoxetine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K601

b:0.4
occ:1.00
 O B:GLY283 2.3 0.4 1.0
O B:GLY174 2.4 0.5 1.0
O A:GLY283 2.4 0.8 1.0
O A:GLY174 2.4 0.6 1.0
O A:VAL282 3.0 0.2 1.0
O A:ILE173 3.0 0.2 1.0
O B:VAL282 3.1 0.1 1.0
O B:ILE173 3.1 0.0 1.0
C B:GLY283 3.4 0.8 1.0
C A:GLY174 3.4 0.2 1.0
C B:GLY174 3.4 0.8 1.0
C A:GLY283 3.4 0.1 1.0
K A:K602 3.5 0.8 1.0
C A:VAL282 4.1 1.0 1.0
CA B:GLY283 4.1 0.0 1.0
CA A:GLY283 4.1 0.3 1.0
C A:ILE173 4.1 0.3 1.0
CA A:GLY174 4.1 0.7 1.0
C B:VAL282 4.2 0.3 1.0
C B:ILE173 4.2 0.2 1.0
CA B:GLY174 4.2 0.1 1.0
O B:TYR175 4.2 0.9 1.0
N B:TYR175 4.3 0.1 1.0
N A:TYR175 4.3 0.1 1.0
O A:TYR175 4.3 0.8 1.0
N B:PHE284 4.3 0.7 1.0
N A:PHE284 4.4 0.7 1.0
CA B:TYR175 4.5 0.5 1.0
C B:TYR175 4.5 0.6 1.0
CA A:TYR175 4.5 0.8 1.0
CA B:PHE284 4.5 0.1 1.0
N A:GLY283 4.6 0.1 1.0
N A:GLY174 4.6 0.7 1.0
C A:TYR175 4.6 0.9 1.0
N B:GLY283 4.6 0.5 1.0
CA A:PHE284 4.6 0.9 1.0
N B:GLY174 4.6 0.6 1.0
O B:PHE284 4.8 0.2 1.0
C B:PHE284 4.8 0.1 1.0
O A:PHE284 4.9 0.7 1.0
C A:PHE284 4.9 0.2 1.0

Potassium binding site 2 out of 6 in 4xdk

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Potassium binding site 2 out of 6 in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with Norfluoxetine


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with Norfluoxetine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K602

b:0.8
occ:1.00
 O A:THR281 2.5 0.4 1.0
O B:THR281 2.7 0.8 1.0
O A:THR172 2.7 0.6 1.0
O B:THR172 2.7 0.2 1.0
O B:ILE173 2.8 0.0 1.0
O A:ILE173 2.8 0.2 1.0
O A:VAL282 2.8 0.2 1.0
O B:VAL282 2.8 0.1 1.0
K A:K601 3.5 0.4 1.0
C A:ILE173 3.5 0.3 1.0
C B:ILE173 3.5 0.2 1.0
K A:K603 3.5 0.2 1.0
C A:VAL282 3.5 1.0 1.0
C B:VAL282 3.6 0.3 1.0
C A:THR281 3.7 0.8 1.0
C A:THR172 3.8 0.4 1.0
C B:THR281 3.8 0.7 1.0
C B:THR172 3.9 0.0 1.0
CA A:ILE173 3.9 0.1 1.0
CA A:VAL282 4.0 0.5 1.0
CA B:ILE173 4.0 0.7 1.0
CA B:VAL282 4.1 0.1 1.0
N A:VAL282 4.3 0.3 1.0
N A:ILE173 4.3 0.9 1.0
N B:ILE173 4.4 0.1 1.0
N A:GLY283 4.4 0.1 1.0
N B:VAL282 4.4 0.3 1.0
N B:GLY174 4.4 0.6 1.0
N A:GLY174 4.4 0.7 1.0
N B:GLY283 4.5 0.5 1.0
O B:GLY174 4.8 0.5 1.0
O B:GLY283 4.8 0.4 1.0
O A:GLY283 4.8 0.8 1.0
O A:GLY174 4.9 0.6 1.0
CA A:GLY283 4.9 0.3 1.0
CA B:GLY174 4.9 0.1 1.0
CA B:GLY283 4.9 0.0 1.0
CA A:THR281 4.9 0.6 1.0
CA A:GLY174 4.9 0.7 1.0

Potassium binding site 3 out of 6 in 4xdk

Go back to Potassium Binding Sites List in 4xdk
Potassium binding site 3 out of 6 in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with Norfluoxetine


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with Norfluoxetine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K603

b:0.2
occ:1.00
 OG1 A:THR172 2.8 0.4 1.0
OG1 A:THR281 2.8 0.3 1.0
O A:THR172 2.9 0.6 1.0
OG1 B:THR281 3.0 0.4 1.0
OG1 B:THR172 3.0 1.0 1.0
O B:THR281 3.0 0.8 1.0
O A:THR281 3.0 0.4 1.0
O B:THR172 3.0 0.2 1.0
CB A:THR281 3.5 0.5 1.0
CB A:THR172 3.5 0.2 1.0
K A:K602 3.5 0.8 1.0
CB B:THR281 3.6 0.8 1.0
CB B:THR172 3.7 0.9 1.0
C A:THR172 3.7 0.4 1.0
C A:THR281 3.8 0.8 1.0
C B:THR281 3.8 0.7 1.0
C B:THR172 3.9 0.0 1.0
CA A:THR172 4.3 0.5 1.0
CA A:THR281 4.3 0.6 1.0
CA B:THR281 4.4 0.5 1.0
CA B:THR172 4.4 0.0 1.0
CG2 A:THR281 4.7 0.6 1.0
N A:ILE173 4.7 0.9 1.0
CG2 A:THR172 4.7 0.6 1.0
N B:VAL282 4.8 0.3 1.0
N A:VAL282 4.9 0.3 1.0
N B:ILE173 4.9 0.1 1.0
CG2 B:THR281 4.9 0.1 1.0
CG2 B:THR172 4.9 0.0 1.0
O A:THR171 4.9 0.4 1.0
O A:THR280 4.9 0.3 1.0
O B:THR280 5.0 1.0 1.0

Potassium binding site 4 out of 6 in 4xdk

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Potassium binding site 4 out of 6 in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with Norfluoxetine


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with Norfluoxetine within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K601

b:0.0
occ:1.00
 O D:GLY283 2.3 0.9 1.0
O C:GLY283 2.4 0.1 1.0
O D:GLY174 2.4 0.1 1.0
O C:GLY174 2.4 0.9 1.0
O D:VAL282 2.9 0.3 1.0
O D:ILE173 2.9 0.8 1.0
O C:VAL282 3.0 0.4 1.0
O C:ILE173 3.0 0.3 1.0
C D:GLY283 3.3 0.8 1.0
C D:GLY174 3.4 0.7 1.0
C C:GLY283 3.4 0.4 1.0
C C:GLY174 3.4 0.8 1.0
K C:K602 3.5 0.4 1.0
C D:VAL282 4.0 0.7 1.0
CA D:GLY283 4.0 0.6 1.0
C D:ILE173 4.0 0.6 1.0
C C:VAL282 4.1 0.5 1.0
CA C:GLY283 4.1 0.9 1.0
CA D:GLY174 4.1 0.3 1.0
C C:ILE173 4.1 0.4 1.0
CA C:GLY174 4.2 0.0 1.0
N D:TYR175 4.3 0.1 1.0
N C:TYR175 4.3 0.3 1.0
O C:TYR175 4.3 0.2 1.0
N D:PHE284 4.3 0.3 1.0
O D:TYR175 4.3 0.7 1.0
N C:PHE284 4.4 0.3 1.0
N D:GLY283 4.5 0.4 1.0
CA D:TYR175 4.5 0.1 1.0
N D:GLY174 4.5 0.0 1.0
CA C:TYR175 4.5 0.5 1.0
N C:GLY283 4.6 0.7 1.0
CA D:PHE284 4.6 0.4 1.0
C C:TYR175 4.6 1.0 1.0
N C:GLY174 4.6 0.5 1.0
C D:TYR175 4.6 0.1 1.0
CA C:PHE284 4.6 0.3 1.0
O C:PHE284 4.9 0.2 1.0
O D:PHE284 4.9 0.1 1.0
C D:PHE284 4.9 0.1 1.0
C C:PHE284 4.9 0.5 1.0

Potassium binding site 5 out of 6 in 4xdk

Go back to Potassium Binding Sites List in 4xdk
Potassium binding site 5 out of 6 in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with Norfluoxetine


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with Norfluoxetine within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K602

b:0.4
occ:1.00
 O C:THR281 2.5 1.0 1.0
O D:THR172 2.6 0.0 1.0
O D:THR281 2.6 0.1 1.0
O C:THR172 2.7 1.0 1.0
O C:ILE173 2.8 0.3 1.0
O C:VAL282 2.8 0.4 1.0
O D:ILE173 2.9 0.8 1.0
O D:VAL282 3.0 0.3 1.0
K C:K603 3.4 0.7 1.0
K C:K601 3.5 0.0 1.0
C C:ILE173 3.5 0.4 1.0
C C:VAL282 3.5 0.5 1.0
C D:ILE173 3.6 0.6 1.0
C C:THR281 3.6 0.9 1.0
C D:VAL282 3.7 0.7 1.0
C D:THR172 3.8 0.1 1.0
C C:THR172 3.8 0.6 1.0
C D:THR281 3.8 0.1 1.0
CA C:ILE173 3.9 0.3 1.0
CA C:VAL282 4.0 0.3 1.0
CA D:ILE173 4.0 0.6 1.0
CA D:VAL282 4.1 0.1 1.0
N C:VAL282 4.2 0.9 1.0
N C:ILE173 4.3 0.6 1.0
N D:ILE173 4.3 0.3 1.0
N C:GLY283 4.4 0.7 1.0
N D:VAL282 4.4 0.9 1.0
N C:GLY174 4.5 0.5 1.0
N D:GLY174 4.5 0.0 1.0
N D:GLY283 4.6 0.4 1.0
O C:GLY283 4.8 0.1 1.0
CA C:GLY283 4.9 0.9 1.0
CA C:THR281 4.9 0.0 1.0
O C:GLY174 4.9 0.9 1.0
O D:GLY174 4.9 0.1 1.0
CA C:GLY174 5.0 0.0 1.0
CA D:GLY174 5.0 0.3 1.0
O D:GLY283 5.0 0.9 1.0
CA D:THR172 5.0 0.1 1.0

Potassium binding site 6 out of 6 in 4xdk

Go back to Potassium Binding Sites List in 4xdk
Potassium binding site 6 out of 6 in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with Norfluoxetine


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 6 of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with Norfluoxetine within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K603

b:0.7
occ:1.00
 OG1 C:THR172 2.8 0.3 1.0
OG1 C:THR281 2.9 0.5 1.0
OG1 D:THR172 2.9 0.9 1.0
O C:THR172 2.9 1.0 1.0
O C:THR281 3.0 1.0 1.0
OG1 D:THR281 3.0 1.0 1.0
O D:THR172 3.1 0.0 1.0
O D:THR281 3.1 0.1 1.0
K C:K602 3.4 0.4 1.0
CB C:THR172 3.5 0.3 1.0
CB C:THR281 3.5 0.6 1.0
CB D:THR172 3.6 0.1 1.0
CB D:THR281 3.7 0.1 1.0
C C:THR172 3.7 0.6 1.0
C C:THR281 3.8 0.9 1.0
C D:THR172 3.9 0.1 1.0
C D:THR281 4.0 0.1 1.0
CA C:THR172 4.3 0.0 1.0
CA C:THR281 4.3 0.0 1.0
CA D:THR172 4.4 0.1 1.0
CA D:THR281 4.5 0.5 1.0
N C:ILE173 4.7 0.6 1.0
CG2 C:THR172 4.7 0.9 1.0
CG2 C:THR281 4.7 0.9 1.0
CG2 D:THR172 4.8 0.5 1.0
N C:VAL282 4.9 0.9 1.0
O C:THR171 4.9 0.3 1.0
N D:ILE173 4.9 0.3 1.0
CG2 D:THR281 4.9 0.8 1.0
N D:VAL282 4.9 0.9 1.0
O D:THR280 5.0 0.5 1.0
O C:THR280 5.0 0.5 1.0

Reference:

A.C.W.Pike, A.Mackenzie, C.Mcclenaghan, P.Aryal, L.Dong, A.Quigley, M.Grieben, S.Goubin, S.Mukhopadhyay, G.F.Ruda, M.V.Clausen, L.Cao, P.E.Brennan, N.A.Burgess-Brown, M.S.P.Sansom, S.J.Tucker, E.P.Carpenter. K2P Channel Gating Mechanisms Revealed By Structures of Trek-2 and A Complex with Prozac Science V. 347 2015.
ISSN: ESSN 1095-9203
DOI: 10.1126/SCIENCE.1261512
Page generated: Sat Aug 9 08:16:45 2025

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