Potassium in PDB 4qbt: Crystal Structure of Tyrosine Bound at the Active Site of Human Tyrosyl Trna Synthetase

All present enzymatic activity of Crystal Structure of Tyrosine Bound at the Active Site of Human Tyrosyl Trna Synthetase:
6.1.1.1;

The structure of Crystal Structure of Tyrosine Bound at the Active Site of Human Tyrosyl Trna Synthetase, PDB code: 4qbt was solved by S.Mathew, P.Schimmel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	34.63 / 2.10
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	75.251, 162.641, 35.422, 90.00, 90.00, 90.00
R / Rfree (%)	21.3 / 26.8

The binding sites of Potassium atom in the Crystal Structure of Tyrosine Bound at the Active Site of Human Tyrosyl Trna Synthetase (pdb code 4qbt). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Crystal Structure of Tyrosine Bound at the Active Site of Human Tyrosyl Trna Synthetase, PDB code: 4qbt:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the Crystal Structure of Tyrosine Bound at the Active Site of Human Tyrosyl Trna Synthetase


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of Tyrosine Bound at the Active Site of Human Tyrosyl Trna Synthetase within 5.0Å range: probe atom residue distance (Å) B Occ A:K502 b:53.1 occ:1.00 O A:HOH601 2.7 24.0 1.0 OH A:TYR52 2.7 45.2 1.0 O A:ALA43 2.7 28.0 1.0 OG1 A:THR42 3.0 28.1 1.0 OH A:TYR97 3.1 33.8 1.0 O A:HOH693 3.3 39.3 1.0 CG2 A:THR45 3.5 39.5 1.0 C A:ALA43 3.9 33.0 1.0 K A:K509 3.9 51.6 1.0 N A:ALA43 4.0 32.2 1.0 CZ A:TYR52 4.0 44.1 1.0 CE2 A:TYR97 4.0 32.4 1.0 CZ A:TYR97 4.0 35.8 1.0 CB A:THR45 4.2 35.4 1.0 CB A:THR42 4.3 31.1 1.0 CA A:ALA43 4.4 33.3 1.0 CE2 A:TYR52 4.5 36.3 1.0 C A:THR42 4.5 28.9 1.0 N A:THR45 4.6 37.3 1.0 CA A:THR42 4.6 28.5 1.0 CB A:ALA43 4.7 38.2 1.0 O A:HOH622 5.0 25.2 1.0 N A:THR44 5.0 34.0 1.0

Potassium binding site 2 out of 2 in the Crystal Structure of Tyrosine Bound at the Active Site of Human Tyrosyl Trna Synthetase


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of Tyrosine Bound at the Active Site of Human Tyrosyl Trna Synthetase within 5.0Å range: probe atom residue distance (Å) B Occ A:K509 b:51.6 occ:1.00 CG2 A:THR45 3.4 39.5 1.0 O A:HOH601 3.5 24.0 1.0 O A:HOH654 3.7 36.8 1.0 NZ A:LYS84 3.9 82.8 1.0 K A:K502 3.9 53.1 1.0 CB A:THR45 4.2 35.4 1.0 OG1 A:THR45 4.3 35.0 1.0 CD A:LYS84 4.6 83.1 1.0 CE A:LYS84 4.7 84.3 1.0 CB A:ALA43 4.9 38.2 1.0 OD2 A:ASP81 5.0 49.9 1.0

M.Sajish, P.Schimmel. A Human Trna Synthetase Is A Potent PARP1-Activating Effector Target For Resveratrol Nature 2014.
ISSN: ESSN 1476-4687
DOI: 10.1038/NATURE14028