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Potassium in PDB 4qbb: Structure of the Foot-and-Mouth Disease Virus Leader Proteinase in Complex with Inhibitor (N~2~-[(3S)-4-({(2R)-1-[(4- Carbamimidamidobutyl)Amino]-4-Methyl-1-Oxopentan-2-Yl}Amino)-3- Hydroxy-4-Oxobutanoyl]-L-Arginyl-L-Prolinamide)

Enzymatic activity of Structure of the Foot-and-Mouth Disease Virus Leader Proteinase in Complex with Inhibitor (N~2~-[(3S)-4-({(2R)-1-[(4- Carbamimidamidobutyl)Amino]-4-Methyl-1-Oxopentan-2-Yl}Amino)-3- Hydroxy-4-Oxobutanoyl]-L-Arginyl-L-Prolinamide)

All present enzymatic activity of Structure of the Foot-and-Mouth Disease Virus Leader Proteinase in Complex with Inhibitor (N~2~-[(3S)-4-({(2R)-1-[(4- Carbamimidamidobutyl)Amino]-4-Methyl-1-Oxopentan-2-Yl}Amino)-3- Hydroxy-4-Oxobutanoyl]-L-Arginyl-L-Prolinamide):
3.4.22.46;

Protein crystallography data

The structure of Structure of the Foot-and-Mouth Disease Virus Leader Proteinase in Complex with Inhibitor (N~2~-[(3S)-4-({(2R)-1-[(4- Carbamimidamidobutyl)Amino]-4-Methyl-1-Oxopentan-2-Yl}Amino)-3- Hydroxy-4-Oxobutanoyl]-L-Arginyl-L-Prolinamide), PDB code: 4qbb was solved by I.Grishkovskaya, J.Steinberger, R.Cencic, M.A.Juliano, L.Juliano, T.Skern, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 45.35 / 1.60
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 45.808, 110.682, 56.774, 90.00, 98.12, 90.00
R / Rfree (%) 17 / 20.1

Potassium Binding Sites:

The binding sites of Potassium atom in the Structure of the Foot-and-Mouth Disease Virus Leader Proteinase in Complex with Inhibitor (N~2~-[(3S)-4-({(2R)-1-[(4- Carbamimidamidobutyl)Amino]-4-Methyl-1-Oxopentan-2-Yl}Amino)-3- Hydroxy-4-Oxobutanoyl]-L-Arginyl-L-Prolinamide) (pdb code 4qbb). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Structure of the Foot-and-Mouth Disease Virus Leader Proteinase in Complex with Inhibitor (N~2~-[(3S)-4-({(2R)-1-[(4- Carbamimidamidobutyl)Amino]-4-Methyl-1-Oxopentan-2-Yl}Amino)-3- Hydroxy-4-Oxobutanoyl]-L-Arginyl-L-Prolinamide), PDB code: 4qbb:

Potassium binding site 1 out of 1 in 4qbb

Go back to Potassium Binding Sites List in 4qbb
Potassium binding site 1 out of 1 in the Structure of the Foot-and-Mouth Disease Virus Leader Proteinase in Complex with Inhibitor (N~2~-[(3S)-4-({(2R)-1-[(4- Carbamimidamidobutyl)Amino]-4-Methyl-1-Oxopentan-2-Yl}Amino)-3- Hydroxy-4-Oxobutanoyl]-L-Arginyl-L-Prolinamide)


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Structure of the Foot-and-Mouth Disease Virus Leader Proteinase in Complex with Inhibitor (N~2~-[(3S)-4-({(2R)-1-[(4- Carbamimidamidobutyl)Amino]-4-Methyl-1-Oxopentan-2-Yl}Amino)-3- Hydroxy-4-Oxobutanoyl]-L-Arginyl-L-Prolinamide) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K201

b:18.0
occ:0.79
 O A:LYS108 2.7 15.4 1.0
O A:HOH413 2.7 39.4 1.0
O A:THR113 2.8 19.8 1.0
O A:LEU111 2.8 18.0 1.0
O A:HOH339 2.8 31.2 1.0
O A:HOH340 2.9 24.7 1.0
C A:THR113 3.7 15.9 1.0
C A:LEU111 3.7 15.9 1.0
C A:LYS108 3.8 16.5 1.0
O B:HOH379 4.0 35.6 1.0
O A:HOH422 4.2 39.0 1.0
CB A:LEU111 4.2 13.4 1.0
CA A:GLY114 4.2 17.4 1.0
N A:GLY114 4.3 16.8 1.0
CA A:LEU111 4.3 14.9 1.0
N A:LEU111 4.3 14.8 1.0
O A:HIS112 4.4 19.7 1.0
C A:HIS112 4.4 15.9 1.0
N A:ILE115 4.4 17.4 1.0
CA A:HIS109 4.5 18.5 1.0
N A:HIS109 4.6 14.7 1.0
N A:THR113 4.6 15.7 1.0
CG1 A:ILE115 4.7 15.6 1.0
C A:HIS109 4.7 16.9 1.0
C A:GLY114 4.7 18.6 1.0
CA A:LYS108 4.8 15.1 1.0
N A:HIS112 4.8 14.8 1.0
CA A:THR113 4.8 15.4 1.0
O A:HIS109 4.9 21.9 1.0
CB A:LYS108 5.0 15.5 1.0
CA A:HIS112 5.0 16.1 1.0

Reference:

J.Steinberger, I.Grishkovskaya, R.Cencic, L.Juliano, M.A.Juliano, T.Skern. Foot-and-Mouth Disease Virus Leader Proteinase: Structural Insights Into the Mechanism of Intermolecular Cleavage. Virology V.470C 397 2014.
ISSN: ISSN 0042-6822
PubMed: 25240326
DOI: 10.1016/J.VIROL.2014.08.023
Page generated: Mon Aug 12 11:52:34 2024

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