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Potassium in PDB 4jta: Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin

Protein crystallography data

The structure of Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin, PDB code: 4jta was solved by R.Mackinnon, A.Banerjee, A.Lee, E.Campbell, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.50
Space group P 4 21 2
Cell size a, b, c (Å), α, β, γ (°) 144.400, 144.400, 284.103, 90.00, 90.00, 90.00
R / Rfree (%) 21 / 23.6

Potassium Binding Sites:

The binding sites of Potassium atom in the Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin (pdb code 4jta). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 6 binding sites of Potassium where determined in the Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin, PDB code: 4jta:
Jump to Potassium binding site number: 1; 2; 3; 4; 5; 6;

Potassium binding site 1 out of 6 in 4jta

Go back to Potassium Binding Sites List in 4jta
Potassium binding site 1 out of 6 in the Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K501

b:23.4
occ:0.50
 O B:GLY372 3.1 41.6 1.0
O B:VAL371 3.5 38.7 1.0
K B:K502 3.6 27.5 0.5
C B:GLY372 3.7 41.2 1.0
CA B:GLY372 4.4 39.3 1.0
N B:TYR373 4.5 40.1 1.0
C B:VAL371 4.5 39.5 1.0
CA B:TYR373 4.6 40.0 1.0
O B:TYR373 4.8 40.5 1.0
C B:TYR373 4.8 40.2 1.0
N B:GLY372 4.9 40.2 1.0

Potassium binding site 2 out of 6 in 4jta

Go back to Potassium Binding Sites List in 4jta
Potassium binding site 2 out of 6 in the Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K502

b:27.5
occ:0.50
 O B:THR370 3.2 38.1 1.0
O B:VAL371 3.2 38.7 1.0
K B:K501 3.6 23.4 0.5
K B:K503 3.6 27.9 0.5
C B:VAL371 3.8 39.5 1.0
CA B:VAL371 4.2 38.1 1.0
C B:THR370 4.3 38.7 1.0
N B:GLY372 4.6 40.2 1.0
N B:VAL371 4.8 39.6 1.0
CA B:GLY372 5.0 39.3 1.0

Potassium binding site 3 out of 6 in 4jta

Go back to Potassium Binding Sites List in 4jta
Potassium binding site 3 out of 6 in the Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K503

b:27.9
occ:0.50
 O B:THR370 3.3 38.1 1.0
OG1 B:THR370 3.3 39.3 1.0
K B:K502 3.6 27.5 0.5
CB B:THR370 3.9 39.5 1.0
C B:THR370 4.2 38.7 1.0
CA B:THR370 4.8 39.0 1.0

Potassium binding site 4 out of 6 in 4jta

Go back to Potassium Binding Sites List in 4jta
Potassium binding site 4 out of 6 in the Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin within 5.0Å range:
probe atom residue distance (Å) B Occ
Q:K501

b:50.5
occ:0.50
 O Q:GLY372 3.2 69.7 1.0
O Q:VAL371 3.5 67.4 1.0
C Q:GLY372 3.8 69.8 1.0
K Q:K502 4.2 62.1 0.5
N Q:TYR373 4.4 69.3 1.0
CA Q:GLY372 4.5 69.3 1.0
CA Q:TYR373 4.5 69.6 1.0
C Q:VAL371 4.6 67.6 1.0
O Q:TYR373 4.6 70.8 1.0
NZ Y:LYS27 4.6 82.4 0.2
C Q:TYR373 4.6 71.3 1.0

Potassium binding site 5 out of 6 in 4jta

Go back to Potassium Binding Sites List in 4jta
Potassium binding site 5 out of 6 in the Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin within 5.0Å range:
probe atom residue distance (Å) B Occ
Q:K502

b:62.1
occ:0.50
 O Q:THR370 3.1 63.9 1.0
K Q:K503 3.4 38.4 0.5
O Q:VAL371 3.4 67.4 1.0
C Q:VAL371 3.9 67.6 1.0
CA Q:VAL371 4.1 66.8 1.0
K Q:K501 4.2 50.5 0.5
C Q:THR370 4.2 64.7 1.0
N Q:VAL371 4.7 65.6 1.0
N Q:GLY372 4.8 68.5 1.0

Potassium binding site 6 out of 6 in 4jta

Go back to Potassium Binding Sites List in 4jta
Potassium binding site 6 out of 6 in the Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 6 of Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin within 5.0Å range:
probe atom residue distance (Å) B Occ
Q:K503

b:38.4
occ:0.50
 O Q:THR370 3.4 63.9 1.0
K Q:K502 3.4 62.1 0.5
OG1 Q:THR370 3.4 63.3 1.0
CB Q:THR370 4.0 65.3 1.0
C Q:THR370 4.4 64.7 1.0
CA Q:THR370 4.9 64.8 1.0

Reference:

A.Banerjee, A.Lee, E.Campbell, R.Mackinnon. Structure of A Pore-Blocking Toxin in Complex with A Eukaryotic Voltage-Dependent K(+) Channel. Elife V. 2 00594 2013.
ISSN: ESSN 2050-084X
PubMed: 23705070
DOI: 10.7554/ELIFE.00594
Page generated: Mon Aug 12 11:07:16 2024

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