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Potassium in PDB 4ix2: Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, Complexed with Imp

Enzymatic activity of Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, Complexed with Imp

All present enzymatic activity of Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, Complexed with Imp:
1.1.1.205;

Protein crystallography data

The structure of Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, Complexed with Imp, PDB code: 4ix2 was solved by J.Osipiuk, N.Maltseva, M.Makowska-Grzyska, M.Gu, W.F.Anderson, A.Joachimiak, Center For Structural Genomics Of Infectious Diseases(Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 38.10 / 2.15
Space group C 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 167.180, 167.158, 93.082, 90.00, 90.00, 90.00
R / Rfree (%) 20.8 / 25.8

Potassium Binding Sites:

The binding sites of Potassium atom in the Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, Complexed with Imp (pdb code 4ix2). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 4 binding sites of Potassium where determined in the Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, Complexed with Imp, PDB code: 4ix2:
Jump to Potassium binding site number: 1; 2; 3; 4;

Potassium binding site 1 out of 4 in 4ix2

Go back to Potassium Binding Sites List in 4ix2
Potassium binding site 1 out of 4 in the Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, Complexed with Imp


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, Complexed with Imp within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K501

b:16.2
occ:1.00
O B:CYS307 2.7 13.8 1.0
O C:GLU471 2.7 15.8 1.0
O B:GLY304 2.7 14.8 1.0
O C:HIS473 2.9 15.6 1.0
O C:SER472 2.9 16.3 1.0
O B:GLY302 2.9 32.2 1.0
C C:SER472 3.4 18.2 1.0
C C:HIS473 3.7 14.3 1.0
C B:CYS307 3.7 13.2 1.0
C C:GLU471 3.8 18.2 1.0
C B:GLY304 3.8 7.3 1.0
CE1 C:HIS475 3.9 16.7 1.0
ND1 C:HIS475 4.0 19.5 1.0
C B:PRO303 4.0 15.7 1.0
CA C:SER472 4.0 8.6 1.0
N C:HIS473 4.1 16.5 1.0
N B:GLY304 4.1 10.5 1.0
C B:GLY302 4.1 20.3 1.0
O B:PRO303 4.2 14.7 1.0
CB B:CYS307 4.2 25.7 1.0
CA B:CYS307 4.3 23.1 1.0
N C:SER472 4.3 7.0 1.0
N B:CYS307 4.3 4.8 1.0
CA B:PRO303 4.3 14.4 1.0
CA C:HIS473 4.4 20.4 1.0
N C:VAL474 4.5 18.1 1.0
CA B:GLY304 4.5 7.2 1.0
CA C:VAL474 4.7 13.7 1.0
N B:THR308 4.7 10.6 1.0
N B:SER305 4.8 13.1 1.0
N B:PRO303 4.8 17.2 1.0
O B:SER305 4.9 22.2 1.0
C B:SER305 4.9 18.3 1.0
CA C:GLU471 4.9 15.4 1.0
CA B:SER305 4.9 9.7 1.0

Potassium binding site 2 out of 4 in 4ix2

Go back to Potassium Binding Sites List in 4ix2
Potassium binding site 2 out of 4 in the Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, Complexed with Imp


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, Complexed with Imp within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K503

b:26.0
occ:1.00
O C:GLY304 2.7 36.0 1.0
O C:CYS307 2.7 8.9 1.0
O C:GLY302 2.8 27.2 1.0
O C:HOH625 3.2 4.9 1.0
C C:CYS307 3.6 7.7 1.0
CB C:CYS307 3.7 7.6 1.0
C C:GLY304 3.8 35.1 1.0
C C:PRO303 3.8 38.7 1.0
C C:GLY302 3.9 15.6 1.0
N C:GLY304 3.9 31.7 1.0
CA C:CYS307 4.0 12.0 1.0
O C:PRO303 4.0 33.5 1.0
N C:CYS307 4.1 27.5 1.0
CA C:PRO303 4.1 35.4 1.0
CA C:GLY304 4.5 31.9 1.0
N C:PRO303 4.5 25.9 1.0
SG C:CYS307 4.6 30.4 1.0
N C:THR308 4.7 4.7 1.0
N C:SER305 4.8 23.9 1.0
O C:SER305 4.9 8.4 1.0
C C:SER305 4.9 9.4 1.0
CA C:GLY302 4.9 14.9 1.0

Potassium binding site 3 out of 4 in 4ix2

Go back to Potassium Binding Sites List in 4ix2
Potassium binding site 3 out of 4 in the Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, Complexed with Imp


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, Complexed with Imp within 5.0Å range:
probe atom residue distance (Å) B Occ
D:K501

b:18.4
occ:1.00
O A:CYS307 2.7 21.8 1.0
O D:GLU471 2.7 19.9 1.0
O A:GLY304 2.7 34.6 1.0
O D:HIS473 2.9 24.7 1.0
O D:SER472 2.9 10.4 1.0
O A:GLY302 3.0 20.3 1.0
C D:SER472 3.4 14.4 1.0
O A:HOH608 3.5 25.4 1.0
C A:CYS307 3.6 14.0 1.0
CE1 D:HIS475 3.6 12.2 1.0
C D:HIS473 3.6 24.8 1.0
C D:GLU471 3.8 23.3 1.0
ND1 D:HIS475 3.8 12.3 1.0
C A:GLY304 3.9 22.9 1.0
CA D:SER472 4.0 6.1 1.0
CB A:CYS307 4.1 16.7 1.0
C A:PRO303 4.1 10.4 1.0
N D:HIS473 4.1 13.4 1.0
C A:GLY302 4.2 17.7 1.0
CA A:CYS307 4.2 7.5 1.0
N A:GLY304 4.2 18.1 1.0
N A:CYS307 4.3 12.5 1.0
O A:PRO303 4.3 14.6 1.0
N D:SER472 4.3 4.9 1.0
N D:VAL474 4.4 17.0 1.0
CA D:HIS473 4.4 19.4 1.0
CA A:PRO303 4.5 14.0 1.0
CA A:GLY304 4.6 20.9 1.0
CA D:VAL474 4.6 10.3 1.0
N A:THR308 4.6 13.5 1.0
O A:SER305 4.7 20.9 1.0
N A:SER305 4.8 26.7 1.0
C A:SER305 4.9 9.7 1.0
NE2 D:HIS475 4.9 11.8 1.0
N A:PRO303 4.9 19.4 1.0
CA A:SER305 4.9 22.1 1.0
CA A:THR308 4.9 4.5 1.0
CA D:GLU471 5.0 20.5 1.0

Potassium binding site 4 out of 4 in 4ix2

Go back to Potassium Binding Sites List in 4ix2
Potassium binding site 4 out of 4 in the Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, Complexed with Imp


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, Complexed with Imp within 5.0Å range:
probe atom residue distance (Å) B Occ
D:K503

b:19.2
occ:1.00
O D:GLY304 2.7 35.8 1.0
O D:CYS307 2.8 9.0 1.0
O D:HOH626 3.1 19.1 1.0
O D:GLY302 3.2 20.2 1.0
C D:CYS307 3.6 7.8 1.0
CB D:CYS307 3.7 18.9 1.0
C D:PRO303 3.8 32.7 1.0
C D:GLY304 3.8 32.5 1.0
O D:PRO303 4.0 33.5 1.0
N D:GLY304 4.0 36.6 1.0
C D:GLY302 4.0 22.5 1.0
CA D:CYS307 4.0 22.3 1.0
N D:CYS307 4.1 27.0 1.0
CA D:PRO303 4.1 22.4 1.0
CA D:GLY304 4.5 26.7 1.0
N D:PRO303 4.5 17.9 1.0
SG D:CYS307 4.7 29.8 1.0
N D:THR308 4.7 8.9 1.0
N D:SER305 4.9 28.9 1.0
O D:SER305 4.9 6.6 1.0
C D:SER305 4.9 8.7 1.0

Reference:

J.Osipiuk, N.Maltseva, M.Makowska-Grzyska, M.Gu, W.F.Anderson, A.Joachimiak. Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, Complexed with Imp. To Be Published.
Page generated: Mon Aug 12 11:02:35 2024

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