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Potassium in PDB 4iu6: Human Methionine Aminopeptidase in Complex with FZ1: Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1

Enzymatic activity of Human Methionine Aminopeptidase in Complex with FZ1: Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1

All present enzymatic activity of Human Methionine Aminopeptidase in Complex with FZ1: Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1:
3.4.11.18;

Protein crystallography data

The structure of Human Methionine Aminopeptidase in Complex with FZ1: Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1, PDB code: 4iu6 was solved by S.B.Gabelli, F.Zhang, M.Miller, J.Liu, L.M.Amzel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.80 / 1.90
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 47.303, 77.344, 47.821, 90.00, 91.49, 90.00
R / Rfree (%) 17.3 / 22.3

Other elements in 4iu6:

The structure of Human Methionine Aminopeptidase in Complex with FZ1: Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1 also contains other interesting chemical elements:

Cobalt (Co) 3 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the Human Methionine Aminopeptidase in Complex with FZ1: Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1 (pdb code 4iu6). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Human Methionine Aminopeptidase in Complex with FZ1: Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1, PDB code: 4iu6:

Potassium binding site 1 out of 1 in 4iu6

Go back to Potassium Binding Sites List in 4iu6
Potassium binding site 1 out of 1 in the Human Methionine Aminopeptidase in Complex with FZ1: Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Human Methionine Aminopeptidase in Complex with FZ1: Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K404

b:21.9
occ:1.00
 O A:VAL209 2.5 19.8 1.0
O A:SER363 2.7 21.3 1.0
O A:HOH514 2.8 20.0 1.0
O A:SER205 2.9 19.6 1.0
O A:ASN207 3.0 21.2 1.0
N A:ASN207 3.6 22.2 1.0
C A:SER205 3.6 20.1 1.0
C A:VAL209 3.7 19.7 1.0
C A:SER363 3.7 21.2 1.0
C A:VAL206 3.8 21.8 1.0
C A:ASN207 3.8 21.0 1.0
O A:VAL206 4.1 22.8 1.0
CA A:ASN207 4.1 21.7 1.0
CB A:SER205 4.2 18.6 1.0
N A:VAL206 4.2 21.0 1.0
CA A:VAL206 4.3 22.5 1.0
O A:HOH541 4.3 20.4 1.0
N A:VAL209 4.3 19.8 1.0
N A:SER363 4.5 22.4 1.0
CA A:VAL209 4.5 19.0 1.0
CA A:SER363 4.5 21.7 1.0
CB A:SER363 4.5 21.3 1.0
CA A:SER205 4.6 19.6 1.0
N A:ALA364 4.6 20.2 1.0
CA A:ALA364 4.7 19.6 1.0
N A:ILE210 4.7 19.8 1.0
CG1 A:ILE225 4.7 23.2 1.0
CD1 A:ILE225 4.8 23.0 1.0
CB A:VAL209 4.8 19.3 1.0
O A:ILE225 4.8 22.0 1.0
N A:GLU208 4.8 20.4 1.0
O A:HOH540 4.9 15.7 1.0
N A:ASN227 4.9 19.6 1.0
CA A:ILE210 4.9 20.9 1.0
C A:GLU208 4.9 19.4 1.0
CB A:ASN227 4.9 18.5 1.0
O A:ILE210 4.9 18.1 1.0

Reference:

F.Zhang, S.Bhat, S.B.Gabelli, X.Chen, M.S.Miller, B.A.Nacev, Y.L.Cheng, D.J.Meyers, K.Tenney, J.S.Shim, P.Crews, L.M.Amzel, D.Ma, J.O.Liu. Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1 in Cells. J.Med.Chem. V. 56 3996 2013.
ISSN: ISSN 0022-2623
PubMed: 23634668
DOI: 10.1021/JM400227Z
Page generated: Mon Aug 12 11:02:19 2024

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