Potassium in PDB 3spj: Apo Inward Rectifier Potassium Channel KIR2.2 I223L Mutant

The structure of Apo Inward Rectifier Potassium Channel KIR2.2 I223L Mutant, PDB code: 3spj was solved by S.B.Hansen, X.Tao, R.Mackinnon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	28.36 / 3.31
Space group	I 4
Cell size a, b, c (Å), α, β, γ (°)	83.769, 83.769, 197.126, 90.00, 90.00, 90.00
R / Rfree (%)	23.5 / 26.7

The binding sites of Potassium atom in the Apo Inward Rectifier Potassium Channel KIR2.2 I223L Mutant (pdb code 3spj). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 5 binding sites of Potassium where determined in the Apo Inward Rectifier Potassium Channel KIR2.2 I223L Mutant, PDB code: 3spj:
Jump to Potassium binding site number: 1; 2; 3; 4; 5;

Potassium binding site 1 out of 5 in the Apo Inward Rectifier Potassium Channel KIR2.2 I223L Mutant


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Apo Inward Rectifier Potassium Channel KIR2.2 I223L Mutant within 5.0Å range: probe atom residue distance (Å) B Occ A:K501 b:0.3 occ:0.25 O A:GLY145 2.8 0.9 1.0 O A:TYR146 2.8 1.0 1.0 K A:K502 3.0 0.7 0.3 C A:TYR146 3.5 0.2 1.0 C A:GLY145 4.0 0.0 1.0 CA A:TYR146 4.1 0.2 1.0 N A:GLY147 4.3 0.1 1.0 CA A:GLY147 4.5 0.5 1.0 N A:TYR146 4.5 0.3 1.0

Potassium binding site 2 out of 5 in the Apo Inward Rectifier Potassium Channel KIR2.2 I223L Mutant


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Apo Inward Rectifier Potassium Channel KIR2.2 I223L Mutant within 5.0Å range: probe atom residue distance (Å) B Occ A:K502 b:0.7 occ:0.25 O A:GLY145 2.7 0.9 1.0 O A:ILE144 2.8 0.7 1.0 K A:K503 2.8 0.7 0.3 K A:K501 3.0 0.3 0.3 C A:GLY145 3.5 0.0 1.0 C A:ILE144 3.9 0.5 1.0 CA A:GLY145 4.0 0.5 1.0 N A:GLY145 4.4 0.2 1.0 N A:TYR146 4.5 0.3 1.0 O A:THR143 4.9 0.5 1.0 CA A:TYR146 4.9 0.2 1.0

Potassium binding site 3 out of 5 in the Apo Inward Rectifier Potassium Channel KIR2.2 I223L Mutant


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Apo Inward Rectifier Potassium Channel KIR2.2 I223L Mutant within 5.0Å range: probe atom residue distance (Å) B Occ A:K503 b:0.7 occ:0.25 O A:ILE144 2.7 0.7 1.0 O A:THR143 2.7 0.5 1.0 K A:K502 2.8 0.7 0.3 K A:K504 3.0 0.7 0.3 C A:ILE144 3.5 0.5 1.0 C A:THR143 3.8 0.4 1.0 CA A:ILE144 4.0 0.9 1.0 N A:ILE144 4.4 0.1 1.0 N A:GLY145 4.5 0.2 1.0 OG1 A:THR143 4.7 0.2 1.0 CA A:GLY145 4.8 0.5 1.0 O A:GLY145 4.9 0.9 1.0

Potassium binding site 4 out of 5 in the Apo Inward Rectifier Potassium Channel KIR2.2 I223L Mutant


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Apo Inward Rectifier Potassium Channel KIR2.2 I223L Mutant within 5.0Å range: probe atom residue distance (Å) B Occ A:K504 b:0.7 occ:0.25 OG1 A:THR143 2.7 0.2 1.0 O A:THR143 2.7 0.5 1.0 K A:K503 3.0 0.7 0.3 C A:THR143 3.7 0.4 1.0 CB A:THR143 3.8 0.8 1.0 CA A:THR143 4.4 0.1 1.0 N A:ILE144 4.6 0.1 1.0 O A:THR142 4.7 0.5 1.0 CA A:ILE144 4.8 0.9 1.0 O A:ILE144 4.9 0.7 1.0

Potassium binding site 5 out of 5 in the Apo Inward Rectifier Potassium Channel KIR2.2 I223L Mutant


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of Apo Inward Rectifier Potassium Channel KIR2.2 I223L Mutant within 5.0Å range: probe atom residue distance (Å) B Occ A:K505 b:0.5 occ:0.25 O A:ASP256 4.6 0.0 1.0 OD1 A:ASP256 4.8 0.4 1.0

S.B.Hansen, X.Tao, R.Mackinnon. Structural Basis of Pip(2) Activation of the Classical Inward Rectifier K(+) Channel KIR2.2. Nature V. 477 495 2011.
ISSN: ISSN 0028-0836
PubMed: 21874019
DOI: 10.1038/NATURE10370