Potassium in PDB 3ccq: Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488U

The structure of Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488U, PDB code: 3ccq was solved by G.Blaha, G.Gurel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 2.90
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	212.330, 299.618, 575.237, 90.00, 90.00, 90.00
R / Rfree (%)	18.6 / 23.3

The structure of Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488U also contains other interesting chemical elements:

Strontium	(Sr)	108 atoms
Magnesium	(Mg)	93 atoms
Cadmium	(Cd)	5 atoms
Chlorine	(Cl)	22 atoms
Sodium	(Na)	75 atoms

The binding sites of Potassium atom in the Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488U (pdb code 3ccq). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488U, PDB code: 3ccq:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488U


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488U within 5.0Å range: probe atom residue distance (Å) B Occ 0:K8401 b:0.4 occ:1.00 O6 0:G2102 2.7 90.0 1.0 O2 0:U2535 3.0 49.0 1.0 O6 0:G2482 3.3 48.2 1.0 N7 0:G2482 3.5 46.4 1.0 C6 0:G2102 3.7 89.9 1.0 C2 0:U2535 3.7 47.0 1.0 N7 0:G2102 3.8 88.4 1.0 OP1 0:U2539 3.9 66.5 1.0 O4' 0:C2536 3.9 49.1 1.0 O 0:HOH4807 4.0 53.8 1.0 C6 0:G2482 4.1 46.9 1.0 C5 0:G2102 4.1 89.6 1.0 C5 0:G2482 4.1 46.3 1.0 N3 0:U2535 4.2 45.3 1.0 C2' 0:U2535 4.2 48.9 1.0 O2 0:C2536 4.3 41.6 1.0 C4' 0:C2536 4.3 50.3 1.0 O2' 0:U2535 4.5 47.4 1.0 C1' 0:C2536 4.5 47.8 1.0 N1 0:U2535 4.6 47.0 1.0 C5' 0:C2536 4.6 50.0 1.0 N6 0:A2486 4.6 70.0 1.0 C8 0:G2482 4.6 46.9 1.0 C1' 0:U2535 4.8 48.2 1.0 C2 0:C2536 4.9 43.0 1.0 N1 0:G2102 4.9 89.8 1.0

Potassium binding site 2 out of 2 in the Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488U


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation A2488U within 5.0Å range: probe atom residue distance (Å) B Occ 0:K8402 b:76.9 occ:1.00 O4 0:U172 2.9 47.3 1.0 O4 0:U163 3.0 47.0 1.0 O 0:HOH9023 3.0 39.9 1.0 O 0:HOH4969 3.1 76.3 1.0 O 0:HOH9159 3.1 37.5 1.0 O 0:HOH9124 3.1 46.0 1.0 OP2 0:C162 3.3 33.5 1.0 CD M:ARG82 3.6 52.8 1.0 O 0:HOH7870 3.6 42.2 1.0 O 0:HOH9339 3.7 42.6 1.0 C4 0:U172 3.8 45.8 1.0 N3 0:U172 3.9 45.7 1.0 C4 0:U163 4.0 44.7 1.0 NE M:ARG82 4.2 53.5 1.0 N4 0:C171 4.4 40.5 1.0 O 0:HOH7869 4.4 84.0 1.0 C5 0:U163 4.6 43.2 1.0 N3 0:C173 4.6 39.3 1.0 P 0:C162 4.6 35.6 1.0 CG M:ARG82 4.6 50.7 1.0 N4 0:C173 4.7 38.1 1.0 O6 0:G164 4.8 36.9 1.0 OP2 0:A169 4.8 36.2 1.0 CB M:ARG82 4.9 47.8 1.0

G.Blaha, G.Gurel, S.J.Schroeder, P.B.Moore, T.A.Steitz. Mutations Outside the Anisomycin-Binding Site Can Make Ribosomes Drug-Resistant. J.Mol.Biol. V. 379 505 2008.
ISSN: ISSN 0022-2836
PubMed: 18455733
DOI: 10.1016/J.JMB.2008.03.075