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Potassium in PDB 2g6p: Crystal Structure of Truncated (Delta 1-89) Human Methionine Aminopeptidase Type 1 in Complex with Pyridyl Pyrimidine Derivative

Enzymatic activity of Crystal Structure of Truncated (Delta 1-89) Human Methionine Aminopeptidase Type 1 in Complex with Pyridyl Pyrimidine Derivative

All present enzymatic activity of Crystal Structure of Truncated (Delta 1-89) Human Methionine Aminopeptidase Type 1 in Complex with Pyridyl Pyrimidine Derivative:
3.4.11.18;

Protein crystallography data

The structure of Crystal Structure of Truncated (Delta 1-89) Human Methionine Aminopeptidase Type 1 in Complex with Pyridyl Pyrimidine Derivative, PDB code: 2g6p was solved by A.Addlagatta, X.Hu, J.O.Liu, B.W.Matthews, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 1.90
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 47.386, 77.522, 47.720, 90.00, 90.82, 90.00
R / Rfree (%) 19.3 / 24.1

Other elements in 2g6p:

The structure of Crystal Structure of Truncated (Delta 1-89) Human Methionine Aminopeptidase Type 1 in Complex with Pyridyl Pyrimidine Derivative also contains other interesting chemical elements:

Cobalt (Co) 3 atoms
Chlorine (Cl) 1 atom

Potassium Binding Sites:

The binding sites of Potassium atom in the Crystal Structure of Truncated (Delta 1-89) Human Methionine Aminopeptidase Type 1 in Complex with Pyridyl Pyrimidine Derivative (pdb code 2g6p). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Crystal Structure of Truncated (Delta 1-89) Human Methionine Aminopeptidase Type 1 in Complex with Pyridyl Pyrimidine Derivative, PDB code: 2g6p:

Potassium binding site 1 out of 1 in 2g6p

Go back to Potassium Binding Sites List in 2g6p
Potassium binding site 1 out of 1 in the Crystal Structure of Truncated (Delta 1-89) Human Methionine Aminopeptidase Type 1 in Complex with Pyridyl Pyrimidine Derivative


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of Truncated (Delta 1-89) Human Methionine Aminopeptidase Type 1 in Complex with Pyridyl Pyrimidine Derivative within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K404

b:26.9
occ:1.00
 O A:VAL209 2.7 17.8 1.0
O A:SER363 2.7 21.6 1.0
O A:HOH531 2.8 22.1 1.0
O A:ASN207 2.9 25.4 1.0
O A:SER205 3.0 23.1 1.0
N A:ASN207 3.5 24.9 1.0
C A:ASN207 3.7 20.4 1.0
C A:VAL206 3.7 22.5 1.0
C A:SER363 3.7 23.7 1.0
C A:SER205 3.7 20.3 1.0
C A:VAL209 3.8 22.0 1.0
CA A:ASN207 3.9 26.7 1.0
O A:VAL206 4.0 23.3 1.0
N A:VAL209 4.2 19.8 1.0
CA A:VAL206 4.2 22.6 1.0
N A:VAL206 4.3 20.2 1.0
CB A:SER205 4.3 18.3 1.0
CA A:SER363 4.5 22.1 1.0
O A:HOH515 4.5 18.2 1.0
CB A:SER363 4.5 21.1 1.0
N A:SER363 4.5 23.9 1.0
CA A:VAL209 4.5 17.6 1.0
N A:ALA364 4.6 21.7 1.0
CG1 A:ILE225 4.6 19.9 1.0
O A:ILE225 4.6 29.3 1.0
CA A:ALA364 4.6 18.9 1.0
CA A:SER205 4.7 24.8 1.0
N A:GLU208 4.8 22.1 1.0
CD1 A:ILE225 4.8 22.5 1.0
CB A:VAL209 4.8 19.9 1.0
N A:ILE210 4.8 17.2 1.0
C A:GLU208 4.9 22.7 1.0
N A:ASN227 4.9 19.5 1.0
O A:HOH505 5.0 17.1 1.0
CB A:ASN227 5.0 17.4 1.0

Reference:

X.Hu, A.Addlagatta, B.W.Matthews, J.O.Liu. Identification of Pyridinylpyrimidines As Inhibitors of Human Methionine Aminopeptidases. Angew.Chem.Int.Ed.Engl. V. 45 3772 2006.
ISSN: ISSN 1433-7851
PubMed: 16724298
DOI: 10.1002/ANIE.200600757
Page generated: Mon Aug 12 06:27:23 2024

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