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Potassium in PDB 2fze: Crystal Structure of the Binary Complex of Human Glutathione-Dependent Formaldehyde Dehydrogenase with Adp-Ribose

Enzymatic activity of Crystal Structure of the Binary Complex of Human Glutathione-Dependent Formaldehyde Dehydrogenase with Adp-Ribose

All present enzymatic activity of Crystal Structure of the Binary Complex of Human Glutathione-Dependent Formaldehyde Dehydrogenase with Adp-Ribose:
1.1.1.1; 1.1.1.284;

Protein crystallography data

The structure of Crystal Structure of the Binary Complex of Human Glutathione-Dependent Formaldehyde Dehydrogenase with Adp-Ribose, PDB code: 2fze was solved by P.C.Sanghani, H.Robinson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.60 / 1.90
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 79.234, 79.234, 310.964, 90.00, 90.00, 90.00
R / Rfree (%) 18.3 / 20.9

Other elements in 2fze:

The structure of Crystal Structure of the Binary Complex of Human Glutathione-Dependent Formaldehyde Dehydrogenase with Adp-Ribose also contains other interesting chemical elements:

Zinc (Zn) 6 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the Crystal Structure of the Binary Complex of Human Glutathione-Dependent Formaldehyde Dehydrogenase with Adp-Ribose (pdb code 2fze). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Crystal Structure of the Binary Complex of Human Glutathione-Dependent Formaldehyde Dehydrogenase with Adp-Ribose, PDB code: 2fze:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in 2fze

Go back to Potassium Binding Sites List in 2fze
Potassium binding site 1 out of 2 in the Crystal Structure of the Binary Complex of Human Glutathione-Dependent Formaldehyde Dehydrogenase with Adp-Ribose


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of the Binary Complex of Human Glutathione-Dependent Formaldehyde Dehydrogenase with Adp-Ribose within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K3001

b:16.3
occ:1.00
 OH A:TYR263 3.0 14.7 1.0
O A:ALA186 3.0 17.8 1.0
O A:LYS187 3.1 15.3 1.0
OE2 A:GLU189 3.1 19.7 1.0
O A:HOH4280 3.2 26.0 1.0
O A:HOH4292 3.2 43.2 1.0
O B:HOH4360 3.2 38.5 1.0
O A:HOH4376 3.3 45.0 1.0
C A:LYS187 3.7 17.8 1.0
CD A:GLU189 3.8 20.1 1.0
CZ A:TYR263 4.0 12.5 1.0
O A:HOH4048 4.0 16.9 1.0
CB A:LYS187 4.0 22.1 1.0
OE1 A:GLU189 4.0 17.7 1.0
C A:ALA186 4.1 18.6 1.0
CE2 A:TYR263 4.3 13.9 1.0
NZ B:LYS106 4.3 15.2 1.0
CA A:LYS187 4.4 19.5 1.0
O B:HOH4039 4.4 17.9 1.0
N A:LEU188 4.4 16.8 1.0
O3 A:PO44001 4.5 55.2 1.0
O A:HOH4141 4.6 26.4 1.0
CA A:LEU188 4.6 17.2 1.0
O A:HOH4125 4.7 27.4 1.0
N A:LYS187 4.7 18.5 1.0
CG A:GLU189 4.9 18.9 1.0
O A:HOH4394 4.9 49.2 1.0

Potassium binding site 2 out of 2 in 2fze

Go back to Potassium Binding Sites List in 2fze
Potassium binding site 2 out of 2 in the Crystal Structure of the Binary Complex of Human Glutathione-Dependent Formaldehyde Dehydrogenase with Adp-Ribose


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of the Binary Complex of Human Glutathione-Dependent Formaldehyde Dehydrogenase with Adp-Ribose within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K3002

b:18.5
occ:1.00
 O B:ALA186 3.0 16.8 1.0
OH B:TYR263 3.0 16.3 1.0
O B:LYS187 3.1 20.4 1.0
O A:HOH4287 3.2 24.8 1.0
OE2 B:GLU189 3.2 20.9 1.0
O A:HOH4439 3.2 41.5 1.0
O A:HOH4191 3.2 39.9 1.0
O B:HOH4369 3.4 46.5 1.0
C B:LYS187 3.7 20.6 1.0
CD B:GLU189 3.8 22.1 1.0
CB B:LYS187 3.9 21.0 1.0
CZ B:TYR263 4.0 16.3 1.0
O B:HOH4022 4.0 17.6 1.0
OE1 B:GLU189 4.1 20.3 1.0
C B:ALA186 4.1 17.7 1.0
CE2 B:TYR263 4.3 17.1 1.0
NZ A:LYS106 4.3 17.4 1.0
O A:HOH4351 4.3 45.8 1.0
CA B:LYS187 4.3 20.4 1.0
O B:HOH4501 4.3 46.2 1.0
O B:HOH4406 4.3 35.8 1.0
O A:HOH4098 4.4 19.8 1.0
O B:HOH4089 4.4 29.2 1.0
N B:LEU188 4.5 20.9 1.0
CA B:LEU188 4.7 19.6 1.0
N B:LYS187 4.7 17.7 1.0
CG B:GLU189 4.9 21.7 1.0

Reference:

P.C.Sanghani, W.I.Davis, L.Zhai, H.Robinson. Structure-Function Relationships in Human Glutathione-Dependent Formaldehyde Dehydrogenase. Role of Glu-67 and Arg-368 in the Catalytic Mechanism. Biochemistry V. 45 4819 2006.
ISSN: ISSN 0006-2960
PubMed: 16605250
DOI: 10.1021/BI052554Q
Page generated: Sat Aug 9 03:27:32 2025

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