Potassium in PDB 1x7x: Crystal Structure of the Human Mitochondrial Branched-Chain Alpha- Ketoacid Dehydrogenase

All present enzymatic activity of Crystal Structure of the Human Mitochondrial Branched-Chain Alpha- Ketoacid Dehydrogenase:
1.2.4.4;

The structure of Crystal Structure of the Human Mitochondrial Branched-Chain Alpha- Ketoacid Dehydrogenase, PDB code: 1x7x was solved by R.M.Wynn, M.Kato, M.Machius, J.L.Chuang, J.Li, D.R.Tomchick, D.T.Chuang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 2.10
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	145.672, 145.672, 69.236, 90.00, 90.00, 120.00
R / Rfree (%)	14.8 / 19

The structure of Crystal Structure of the Human Mitochondrial Branched-Chain Alpha- Ketoacid Dehydrogenase also contains other interesting chemical elements:

Manganese	(Mn)	1 atom
Chlorine	(Cl)	1 atom

The binding sites of Potassium atom in the Crystal Structure of the Human Mitochondrial Branched-Chain Alpha- Ketoacid Dehydrogenase (pdb code 1x7x). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Crystal Structure of the Human Mitochondrial Branched-Chain Alpha- Ketoacid Dehydrogenase, PDB code: 1x7x:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the Crystal Structure of the Human Mitochondrial Branched-Chain Alpha- Ketoacid Dehydrogenase


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of the Human Mitochondrial Branched-Chain Alpha- Ketoacid Dehydrogenase within 5.0Å range: probe atom residue distance (Å) B Occ A:K701 b:15.9 occ:1.00 O A:PRO163 2.6 20.9 1.0 O A:HOH805 2.8 11.9 1.0 OE1 A:GLN167 2.8 20.7 1.0 OE1 A:GLN112 2.9 29.2 1.0 O A:SER161 2.9 19.1 1.0 OG A:SER161 2.9 18.9 1.0 OG1 A:THR166 3.0 21.4 1.0 CD A:GLN112 3.6 31.3 1.0 C A:SER161 3.7 19.5 1.0 C A:PRO163 3.7 19.7 1.0 CD A:GLN167 3.9 22.0 1.0 CB A:SER161 4.1 20.2 1.0 N A:SER161 4.2 20.3 1.0 O A:HOH809 4.2 13.6 1.0 CA A:SER161 4.2 20.3 1.0 N A:THR166 4.2 20.4 1.0 N A:GLN167 4.3 20.3 1.0 NE2 A:GLN112 4.4 33.2 1.0 CB A:THR166 4.4 22.0 1.0 N A:PRO163 4.4 18.8 1.0 CG A:GLN112 4.4 28.3 1.0 N A:ALA165 4.4 19.3 1.0 C A:SER162 4.5 19.4 1.0 CA A:LEU164 4.5 19.9 1.0 CB A:GLN167 4.5 21.7 1.0 N A:LEU164 4.6 19.1 1.0 C A:LEU164 4.6 20.0 1.0 CA A:PRO163 4.6 19.9 1.0 O A:GLY111 4.6 24.9 1.0 N A:SER162 4.6 20.1 1.0 O A:HOH833 4.7 17.9 1.0 OE2 B:GLU113 4.7 22.5 1.0 CD A:PRO163 4.7 19.3 1.0 O A:HOH818 4.7 15.8 1.0 CA A:THR166 4.7 20.5 1.0 CG A:GLN167 4.7 20.1 1.0 NE2 A:GLN167 4.8 20.4 1.0 O A:SER162 4.9 18.9 1.0 CB A:GLN112 4.9 28.4 1.0 C A:THR166 4.9 21.2 1.0 CG2 A:THR166 5.0 19.5 1.0 CA A:SER162 5.0 19.3 1.0

Potassium binding site 2 out of 2 in the Crystal Structure of the Human Mitochondrial Branched-Chain Alpha- Ketoacid Dehydrogenase


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of the Human Mitochondrial Branched-Chain Alpha- Ketoacid Dehydrogenase within 5.0Å range: probe atom residue distance (Å) B Occ B:K702 b:15.7 occ:1.00 O B:ASN183 2.6 21.3 1.0 O B:CYS178 2.7 18.7 1.0 O B:GLY128 2.7 20.7 1.0 O B:ASP181 2.8 20.6 1.0 O B:LEU130 2.9 18.9 1.0 O B:HOH929 3.0 15.3 1.0 OG1 B:THR131 3.4 22.9 1.0 C B:LEU130 3.7 20.1 1.0 C B:ASN183 3.8 21.5 1.0 C B:ASP181 3.9 21.9 1.0 C B:CYS178 3.9 21.0 1.0 C B:GLY128 3.9 20.9 1.0 O B:ILE179 4.0 20.9 1.0 SG B:CYS185 4.0 24.7 1.0 N B:LEU130 4.1 18.2 1.0 O B:HOH1036 4.2 34.0 1.0 C B:SER129 4.2 19.1 1.0 N B:CYS185 4.2 21.1 1.0 N B:ASN183 4.3 22.2 1.0 CB B:ASP181 4.3 22.9 1.0 CB B:CYS185 4.3 19.6 1.0 N B:ASP181 4.3 21.8 1.0 C B:ILE179 4.3 22.1 1.0 CA B:SER129 4.4 19.4 1.0 CA B:ASP181 4.4 22.3 1.0 CA B:PRO184 4.4 20.2 1.0 N B:THR131 4.4 20.9 1.0 N B:PRO184 4.5 21.2 1.0 CA B:ILE179 4.5 21.6 1.0 CA B:LEU130 4.6 19.7 1.0 CB B:THR131 4.6 20.5 1.0 N B:SER129 4.6 20.8 1.0 C B:PRO184 4.7 21.1 1.0 N B:ILE179 4.7 21.0 1.0 CA B:THR131 4.7 20.2 1.0 O B:SER129 4.7 18.4 1.0 CA B:ASN183 4.7 21.4 1.0 N B:LYS182 4.9 21.1 1.0 CA B:CYS178 4.9 20.1 1.0 CA B:CYS185 4.9 20.8 1.0 CA B:GLY128 5.0 20.0 1.0

R.M.Wynn, M.Kato, M.Machius, J.L.Chuang, J.Li, D.R.Tomchick, D.T.Chuang. Molecular Mechanism For Regulation of the Human Mitochondrial Branched-Chain Alpha-Ketoacid Dehydrogenase Complex By Phosphorylation Structure V. 12 2185 2004.
ISSN: ISSN 0969-2126
PubMed: 15576032
DOI: 10.1016/J.STR.2004.09.013