Potassium in PDB 1jr1: Crystal Structure of Inosine Monophosphate Dehydrogenase in Complex with Mycophenolic Acid

All present enzymatic activity of Crystal Structure of Inosine Monophosphate Dehydrogenase in Complex with Mycophenolic Acid:
1.1.1.205;

The structure of Crystal Structure of Inosine Monophosphate Dehydrogenase in Complex with Mycophenolic Acid, PDB code: 1jr1 was solved by M.D.Sintchak, M.A.Fleming, O.Futer, S.A.Raybuck, S.P.Chambers, P.R.Caron, M.A.Murcko, K.P.Wilson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	8.00 / 2.60
Space group	P 4
Cell size a, b, c (Å), α, β, γ (°)	110.600, 110.600, 111.000, 90.00, 90.00, 90.00
R / Rfree (%)	21.7 / 28.5

The binding sites of Potassium atom in the Crystal Structure of Inosine Monophosphate Dehydrogenase in Complex with Mycophenolic Acid (pdb code 1jr1). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Crystal Structure of Inosine Monophosphate Dehydrogenase in Complex with Mycophenolic Acid, PDB code: 1jr1:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the Crystal Structure of Inosine Monophosphate Dehydrogenase in Complex with Mycophenolic Acid


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of Inosine Monophosphate Dehydrogenase in Complex with Mycophenolic Acid within 5.0Å range: probe atom residue distance (Å) B Occ A:K601 b:41.5 occ:1.00 O A:GLY328 2.8 23.2 1.0 O A:CYS331 2.9 22.6 1.0 O A:GLY326 3.0 18.8 1.0 CB A:CYS331 3.3 19.3 1.0 C A:CYS331 3.6 21.4 1.0 O A:HOH663 3.6 24.1 1.0 CA A:CYS331 3.6 20.3 1.0 N A:CYS331 3.7 19.3 1.0 C A:CYS327 3.7 24.9 1.0 C A:GLY328 3.7 23.1 1.0 C A:GLY326 3.8 18.2 1.0 N A:GLY328 3.9 23.6 1.0 CA A:CYS327 3.9 22.3 1.0 O A:CYS327 4.0 26.6 1.0 N A:CYS327 4.2 20.6 1.0 O A:SER329 4.4 25.7 1.0 CA A:GLY328 4.4 23.9 1.0 C A:SER329 4.6 23.3 1.0 N A:SER329 4.6 23.7 1.0 CA A:SER329 4.8 22.2 1.0 N A:ILE332 4.8 19.0 1.0 CA A:GLY326 4.8 17.1 1.0 SG A:CYS331 4.9 16.8 1.0 C A:ILE330 4.9 20.6 1.0 OE1 A:GLU335 5.0 35.5 1.0

Potassium binding site 2 out of 2 in the Crystal Structure of Inosine Monophosphate Dehydrogenase in Complex with Mycophenolic Acid


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of Inosine Monophosphate Dehydrogenase in Complex with Mycophenolic Acid within 5.0Å range: probe atom residue distance (Å) B Occ B:K602 b:37.5 occ:1.00 O B:GLY328 2.7 22.3 1.0 O B:CYS331 2.9 29.0 1.0 O B:GLY326 3.1 23.3 1.0 C B:GLY328 3.7 23.3 1.0 C B:CYS331 3.7 29.1 1.0 CB B:CYS331 3.8 27.7 1.0 N B:CYS331 3.9 28.6 1.0 O B:HOH700 3.9 28.6 1.0 CA B:CYS331 4.0 28.9 1.0 C B:CYS327 4.2 24.8 1.0 O B:CYS327 4.3 26.1 1.0 O B:SER329 4.3 21.3 1.0 C B:GLY326 4.3 21.6 1.0 N B:GLY328 4.3 24.5 1.0 C B:SER329 4.4 21.2 1.0 N B:SER329 4.5 23.7 1.0 CA B:SER329 4.5 21.7 1.0 CA B:CYS327 4.6 23.2 1.0 CA B:GLY328 4.6 23.4 1.0 O B:HOH703 4.8 45.3 1.0 N B:ILE330 4.9 21.9 1.0 N B:ILE332 4.9 29.3 1.0 N B:CYS327 4.9 23.2 1.0 C B:ILE330 5.0 26.5 1.0

M.D.Sintchak, M.A.Fleming, O.Futer, S.A.Raybuck, S.P.Chambers, P.R.Caron, M.A.Murcko, K.P.Wilson. Structure and Mechanism of Inosine Monophosphate Dehydrogenase in Complex with the Immunosuppressant Mycophenolic Acid. Cell(Cambridge,Mass.) V. 85 921 1996.
ISSN: ISSN 0092-8674
PubMed: 8681386
DOI: 10.1016/S0092-8674(00)81275-1