Potassium in PDB 9goy: Crystal Structure of Fab E2-Reca in Complex with CD38

All present enzymatic activity of Crystal Structure of Fab E2-Reca in Complex with CD38:
2.4.99.20; 3.2.2.6;

The structure of Crystal Structure of Fab E2-Reca in Complex with CD38, PDB code: 9goy was solved by C.Dreyfus, G.Fritz, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.22 / 2.70
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	131.29, 61.07, 124.12, 90, 108.6, 90
R / Rfree (%)	24.3 / 27.9

The structure of Crystal Structure of Fab E2-Reca in Complex with CD38 also contains other interesting chemical elements:

Chlorine

(Cl)

2 atoms

The binding sites of Potassium atom in the Crystal Structure of Fab E2-Reca in Complex with CD38 (pdb code 9goy). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Crystal Structure of Fab E2-Reca in Complex with CD38, PDB code: 9goy:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the Crystal Structure of Fab E2-Reca in Complex with CD38


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of Fab E2-Reca in Complex with CD38 within 5.0Å range: probe atom residue distance (Å) B Occ A:K401 b:62.5 occ:1.00 OG A:SER126 3.8 91.2 1.0 N A:THR221 4.1 87.9 1.0 OG1 A:THR221 4.1 85.9 1.0 NH1 A:ARG127 4.2 108.5 1.0 CB A:THR221 4.2 84.2 1.0 N A:ARG127 4.2 94.6 1.0 CB A:SER220 4.2 91.3 1.0 CA A:SER126 4.2 89.5 1.0 N A:PHE222 4.3 83.0 1.0 CZ3 A:TRP125 4.4 82.8 1.0 CB A:SER126 4.5 90.2 1.0 OG A:SER220 4.6 89.7 1.0 CA A:THR221 4.6 85.4 1.0 C A:SER126 4.7 92.6 1.0 O A:TRP125 4.7 84.1 1.0 CB A:PHE222 4.8 81.4 1.0 CE3 A:TRP125 4.9 82.8 1.0 CG A:ARG127 4.9 105.4 1.0 C A:THR221 4.9 84.0 1.0 C A:SER220 4.9 89.5 1.0 CA A:SER220 5.0 91.6 1.0

Potassium binding site 2 out of 2 in the Crystal Structure of Fab E2-Reca in Complex with CD38


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of Fab E2-Reca in Complex with CD38 within 5.0Å range: probe atom residue distance (Å) B Occ A:K402 b:91.4 occ:1.00 OD1 A:ASP100 3.3 82.2 1.0 ND2 A:ASN182 3.6 74.2 1.0 CG A:ASN182 3.9 72.3 1.0 O A:ILE101 4.0 79.0 1.0 CB A:ASN182 4.3 71.1 1.0 OD1 A:ASN182 4.5 71.1 1.0 CG A:ASP100 4.5 82.1 1.0 CA A:ASP100 4.6 80.2 1.0 C A:ASP100 4.7 79.7 1.0 CG2 A:THR102 4.8 82.2 1.0 C A:ILE101 4.9 78.6 1.0 N A:ILE101 4.9 79.3 1.0

J.Loyau, T.Monney, M.Montefiori, F.Bokhovchuk, J.Streuli, M.Blackburn, A.Goepfert, L.N.Caro, S.Chakraborti, S.De Angelis, C.Grandclement, S.Blein, M.L.Mbow, A.Srivastava, M.Perro, S.Sammicheli, E.A.Zhukovsky, M.Dyson, C.Dreyfus. Biparatopic Binding of Isb 1442 to CD38 in Trans Enables Increased Cell Antibody Density and Increased Avidity. Mabs V. 17 57471 2025.
ISSN: ESSN 1942-0870
PubMed: 39882744
DOI: 10.1080/19420862.2025.2457471