Potassium in PDB 9ft7: Structure of the Human Two Pore Domain Potassium Ion Channel Thik-1 (K2P13.1) in A Closed Conformation

The binding sites of Potassium atom in the Structure of the Human Two Pore Domain Potassium Ion Channel Thik-1 (K2P13.1) in A Closed Conformation (pdb code 9ft7). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Structure of the Human Two Pore Domain Potassium Ion Channel Thik-1 (K2P13.1) in A Closed Conformation, PDB code: 9ft7:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the Structure of the Human Two Pore Domain Potassium Ion Channel Thik-1 (K2P13.1) in A Closed Conformation


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Structure of the Human Two Pore Domain Potassium Ion Channel Thik-1 (K2P13.1) in A Closed Conformation within 5.0Å range: probe atom residue distance (Å) B Occ A:K402 b:20.6 occ:1.00 O A:PHE240 2.8 47.5 1.0 O B:PHE240 2.8 47.8 1.0 O A:GLY239 3.0 38.9 1.0 O B:GLY239 3.0 39.1 1.0 O B:GLY112 3.0 30.8 1.0 O A:GLY112 3.0 30.9 1.0 O B:PHE113 3.2 44.9 1.0 O A:PHE113 3.2 44.5 1.0 C A:PHE240 3.5 40.7 1.0 C B:PHE240 3.5 40.9 1.0 C B:PHE113 3.7 30.7 1.0 C A:PHE113 3.7 30.5 1.0 CA A:PHE240 3.9 23.0 1.0 CA B:PHE240 3.9 22.4 1.0 C A:GLY239 4.1 25.3 1.0 C B:GLY239 4.1 25.0 1.0 C B:GLY112 4.2 24.3 1.0 C A:GLY112 4.2 24.0 1.0 CA B:PHE113 4.2 28.1 1.0 CA A:PHE113 4.2 28.3 1.0 N A:GLY241 4.5 46.0 1.0 N B:GLY241 4.5 46.4 1.0 N B:GLY114 4.5 36.1 1.0 N A:GLY114 4.5 35.9 1.0 N A:PHE240 4.6 19.4 1.0 N B:PHE240 4.6 19.2 1.0 N B:PHE113 4.7 32.2 1.0 N A:PHE113 4.7 31.8 1.0 CA B:GLY114 4.8 34.3 1.0 CA A:GLY114 4.8 34.8 1.0 CA B:GLY241 4.9 39.3 1.0 CA A:GLY241 4.9 39.4 1.0

Potassium binding site 2 out of 2 in the Structure of the Human Two Pore Domain Potassium Ion Channel Thik-1 (K2P13.1) in A Closed Conformation


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Structure of the Human Two Pore Domain Potassium Ion Channel Thik-1 (K2P13.1) in A Closed Conformation within 5.0Å range: probe atom residue distance (Å) B Occ A:K403 b:26.7 occ:1.00 O B:THR237 2.8 38.4 1.0 O A:THR237 2.8 38.4 1.0 O A:THR110 2.8 30.2 1.0 O B:THR110 2.8 30.5 1.0 O B:ILE238 2.9 40.6 1.0 O A:ILE238 2.9 40.6 1.0 O A:ILE111 3.0 37.1 1.0 O B:ILE111 3.0 36.9 1.0 C B:ILE238 3.8 21.5 1.0 C A:ILE238 3.8 22.4 1.0 C B:ILE111 3.8 21.2 1.0 C A:ILE111 3.8 22.0 1.0 C A:THR237 4.0 21.7 1.0 C B:THR237 4.0 21.6 1.0 C A:THR110 4.0 22.1 1.0 C B:THR110 4.0 22.2 1.0 CA A:ILE238 4.2 19.8 1.0 CA B:ILE238 4.2 19.0 1.0 CA A:ILE111 4.2 15.0 1.0 CA B:ILE111 4.2 14.2 1.0 N A:ILE238 4.6 21.2 1.0 N B:ILE238 4.6 20.9 1.0 N B:ILE111 4.7 26.2 1.0 N A:ILE111 4.7 25.7 1.0 N A:GLY112 4.7 29.3 1.0 N B:GLY112 4.7 29.2 1.0 N B:GLY239 4.8 14.3 1.0 N A:GLY239 4.8 16.2 1.0 O B:GLY239 5.0 39.1 1.0 O A:GLY239 5.0 38.9 1.0 CA A:GLY112 5.0 25.6 1.0 CA B:GLY112 5.0 25.3 1.0

K.E.J.Rodstrom, B.Eymsh, P.Proks, M.S.Hayre, S.Cordeiro, E.Mendez-Otalvaro, C.Madry, A.Rowland, W.Kopec, S.Newstead, T.Baukrowitz, M.Schewe, S.J.Tucker. Cryo-Em Structure of the Human Thik-1 K2P K + Channel Reveals A Lower Y Gate Regulated By Lipids and Anesthetics. Nat.Struct.Mol.Biol. 2025.
ISSN: ESSN 1545-9985
PubMed: 40011745
DOI: 10.1038/S41594-025-01497-6