Potassium in PDB 8x4r: Pyruvate Kinase M2 (PKM2) Mutant in Complex with Phenylalanine

The structure of Pyruvate Kinase M2 (PKM2) Mutant in Complex with Phenylalanine, PDB code: 8x4r was solved by W.C.Wang, T.H.Su, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	27.11 / 2.18
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	98.142, 69.399, 168.818, 90, 106.54, 90
R / Rfree (%)	19.8 / 24.1

The binding sites of Potassium atom in the Pyruvate Kinase M2 (PKM2) Mutant in Complex with Phenylalanine (pdb code 8x4r). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 4 binding sites of Potassium where determined in the Pyruvate Kinase M2 (PKM2) Mutant in Complex with Phenylalanine, PDB code: 8x4r:
Jump to Potassium binding site number: 1; 2; 3; 4;

Potassium binding site 1 out of 4 in the Pyruvate Kinase M2 (PKM2) Mutant in Complex with Phenylalanine


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Pyruvate Kinase M2 (PKM2) Mutant in Complex with Phenylalanine within 5.0Å range: probe atom residue distance (Å) B Occ A:K601 b:35.2 occ:1.00 O A:THR114 2.6 34.5 1.0 OD1 A:ASN75 2.7 35.8 1.0 OD2 A:ASP113 2.7 37.5 1.0 O A:HOH736 2.7 28.5 1.0 OG A:SER77 2.8 40.2 1.0 C A:THR114 3.7 34.4 1.0 OG A:SER243 3.7 37.9 1.0 CG A:ASN75 3.7 38.7 1.0 CG A:ASP113 3.8 35.4 1.0 CB A:SER77 3.8 39.7 1.0 O A:ASP113 3.9 35.1 1.0 O A:HOH774 4.0 48.8 1.0 OE2 A:GLU118 4.1 51.1 1.0 ND2 A:ASN75 4.2 36.7 1.0 N A:SER77 4.2 37.6 1.0 C A:ASP113 4.2 30.7 1.0 CA A:LYS115 4.2 34.8 1.0 N A:LYS115 4.3 34.7 1.0 NH1 A:ARG73 4.3 40.1 1.0 NZ A:LYS270 4.3 48.5 1.0 O A:LYS115 4.4 31.2 1.0 N A:THR114 4.5 31.9 1.0 CB A:ASP113 4.5 30.1 1.0 CA A:SER77 4.5 41.0 1.0 OD1 A:ASP113 4.6 37.5 1.0 O A:HOH821 4.7 55.1 1.0 CA A:THR114 4.7 30.9 1.0 CB A:SER243 4.8 38.3 1.0 C A:LYS115 4.8 31.6 1.0 N A:PHE76 4.9 36.3 1.0 CB A:ASN75 4.9 37.4 1.0 CA A:ASN75 5.0 34.9 1.0

Potassium binding site 2 out of 4 in the Pyruvate Kinase M2 (PKM2) Mutant in Complex with Phenylalanine


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Pyruvate Kinase M2 (PKM2) Mutant in Complex with Phenylalanine within 5.0Å range: probe atom residue distance (Å) B Occ B:K601 b:44.7 occ:1.00 O B:THR114 2.7 32.1 1.0 OD1 B:ASN75 2.7 30.1 1.0 O B:HOH722 2.7 37.3 1.0 OD2 B:ASP113 2.9 33.5 1.0 OG B:SER77 2.9 41.0 1.0 C B:THR114 3.6 31.2 1.0 O B:ASP113 3.7 28.5 1.0 CG B:ASN75 3.8 31.2 1.0 CG B:ASP113 3.8 31.4 1.0 OG B:SER243 3.9 38.8 1.0 C B:ASP113 4.0 29.8 1.0 CB B:SER77 4.1 39.7 1.0 CA B:LYS115 4.1 38.7 1.0 N B:LYS115 4.2 33.8 1.0 N B:SER77 4.2 35.3 1.0 O B:LYS115 4.3 40.1 1.0 N B:THR114 4.3 30.3 1.0 NZ B:LYS270 4.4 52.1 1.0 ND2 B:ASN75 4.4 32.8 1.0 CB B:ASP113 4.5 28.4 1.0 NH1 B:ARG73 4.5 39.1 1.0 CA B:THR114 4.6 31.2 1.0 CA B:SER77 4.6 40.1 1.0 C B:LYS115 4.6 37.0 1.0 N B:PHE76 4.7 32.9 1.0 OD1 B:ASP113 4.7 35.3 1.0 CA B:ASP113 4.8 28.0 1.0 CA B:ASN75 4.9 27.6 1.0 CB B:ASN75 4.9 30.0 1.0

Potassium binding site 3 out of 4 in the Pyruvate Kinase M2 (PKM2) Mutant in Complex with Phenylalanine


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Pyruvate Kinase M2 (PKM2) Mutant in Complex with Phenylalanine within 5.0Å range: probe atom residue distance (Å) B Occ C:K601 b:36.7 occ:1.00 OD1 C:ASN75 2.7 37.5 1.0 O C:HOH742 2.7 33.8 1.0 OG C:SER77 2.7 41.4 1.0 O C:THR114 2.8 34.9 1.0 OD2 C:ASP113 2.9 39.1 1.0 OG C:SER243 3.6 34.0 1.0 CG C:ASN75 3.6 34.6 1.0 C C:THR114 3.6 32.3 1.0 CG C:ASP113 3.8 36.4 1.0 CB C:SER77 3.9 41.3 1.0 O C:ASP113 4.0 28.6 1.0 O C:HOH774 4.0 54.0 1.0 ND2 C:ASN75 4.1 32.2 1.0 NZ C:LYS270 4.2 48.3 1.0 N C:SER77 4.2 42.4 1.0 C C:ASP113 4.2 31.4 1.0 N C:LYS115 4.2 36.5 1.0 CA C:LYS115 4.2 40.2 1.0 NH2 C:ARG73 4.3 34.6 1.0 CB C:ASP113 4.5 34.8 1.0 N C:THR114 4.5 28.8 1.0 CA C:SER77 4.5 40.2 1.0 O C:LYS115 4.5 38.2 1.0 OE2 C:GLU118 4.6 55.7 1.0 OD1 C:ASP113 4.7 36.5 1.0 CA C:THR114 4.7 31.1 1.0 C C:LYS115 4.8 38.8 1.0 CB C:SER243 4.8 31.2 1.0 N C:PHE76 4.8 39.1 1.0 CB C:ASN75 4.8 35.5 1.0 CA C:ASP113 4.9 31.7 1.0 CA C:ASN75 4.9 36.5 1.0

Potassium binding site 4 out of 4 in the Pyruvate Kinase M2 (PKM2) Mutant in Complex with Phenylalanine


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Pyruvate Kinase M2 (PKM2) Mutant in Complex with Phenylalanine within 5.0Å range: probe atom residue distance (Å) B Occ D:K601 b:44.9 occ:1.00 O D:HOH782 2.5 44.2 1.0 O D:THR114 2.7 38.4 1.0 OD1 D:ASN75 2.7 36.6 1.0 OD2 D:ASP113 2.7 36.7 1.0 OG D:SER77 2.9 62.9 1.0 C D:THR114 3.6 40.6 1.0 CG D:ASN75 3.7 37.9 1.0 O D:ASP113 3.7 37.4 1.0 CG D:ASP113 3.8 39.4 1.0 OG D:SER243 3.9 40.5 1.0 CB D:SER77 4.0 59.1 1.0 NZ D:LYS270 4.0 41.6 1.0 C D:ASP113 4.1 37.3 1.0 N D:LYS115 4.2 43.5 1.0 CA D:LYS115 4.2 45.4 1.0 ND2 D:ASN75 4.2 40.6 1.0 N D:SER77 4.3 49.8 1.0 CB D:ASP113 4.4 36.5 1.0 N D:THR114 4.4 36.6 1.0 NH1 D:ARG73 4.5 40.8 1.0 O D:LYS115 4.6 41.5 1.0 O D:HOH708 4.6 54.4 1.0 CA D:THR114 4.6 37.3 1.0 OD1 D:ASP113 4.7 36.1 1.0 CA D:SER77 4.7 54.2 1.0 C D:LYS115 4.7 40.4 1.0 N D:PHE76 4.8 40.6 1.0 CB D:ASN75 4.8 34.6 1.0 CA D:ASP113 4.9 36.7 1.0 CA D:ASN75 4.9 34.4 1.0

W.C.Wang, T.H.Su. Pyruvate Kinase M2 (PKM2) Mutant in Complex with Phenylalanine To Be Published.