Potassium in PDB 8ti2: Cryo-Em Structure of A SUR1/KIR6.2-Q52R Atp-Sensitive Potassium Channel in the Presence of PIP2 in the Open Conformation

Potassium Binding Sites:

The binding sites of Potassium atom in the Cryo-Em Structure of A SUR1/KIR6.2-Q52R Atp-Sensitive Potassium Channel in the Presence of PIP2 in the Open Conformation (pdb code 8ti2). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 4 binding sites of Potassium where determined in the Cryo-Em Structure of A SUR1/KIR6.2-Q52R Atp-Sensitive Potassium Channel in the Presence of PIP2 in the Open Conformation, PDB code: 8ti2:
Jump to Potassium binding site number: 1; 2; 3; 4;

Potassium binding site 1 out of 4 in 8ti2

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Potassium Binding Sites List in 8ti2

Potassium binding site 1 out of 4 in the Cryo-Em Structure of A SUR1/KIR6.2-Q52R Atp-Sensitive Potassium Channel in the Presence of PIP2 in the Open Conformation

Mono view

Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Cryo-Em Structure of A SUR1/KIR6.2-Q52R Atp-Sensitive Potassium Channel in the Presence of PIP2 in the Open Conformation within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:K402 b:124.0 occ:1.00	OG1	C:THR130	3.2	89.9	1.0
	OG1	B:THR130	3.2	93.3	1.0
	OG1	D:THR130	3.2	94.8	1.0
	OG1	A:THR130	3.2	97.6	1.0
	CB	B:THR130	4.3	92.8	1.0
	CB	C:THR130	4.3	90.3	1.0
	CB	D:THR130	4.3	95.1	1.0
	CB	A:THR130	4.3	97.4	1.0
	O	A:THR130	4.6	111.8	1.0
	O	B:THR130	4.6	108.0	1.0
	O	D:THR130	4.6	110.2	1.0
	O	C:THR130	4.6	105.5	1.0
	O	C:VAL129	4.9	90.4	1.0
	O	B:VAL129	4.9	88.8	1.0
	O	D:VAL129	4.9	90.6	1.0
	O	A:VAL129	4.9	95.5	1.0

Potassium binding site 2 out of 4 in 8ti2

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Potassium Binding Sites List in 8ti2

Potassium binding site 2 out of 4 in the Cryo-Em Structure of A SUR1/KIR6.2-Q52R Atp-Sensitive Potassium Channel in the Presence of PIP2 in the Open Conformation

Mono view

Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Cryo-Em Structure of A SUR1/KIR6.2-Q52R Atp-Sensitive Potassium Channel in the Presence of PIP2 in the Open Conformation within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:K403 b:88.0 occ:1.00	O	D:GLY132	2.7	112.5	1.0
	O	A:GLY132	2.7	106.4	1.0
	O	B:GLY132	2.7	107.5	1.0
	O	C:GLY132	2.7	110.6	1.0
	O	A:PHE133	2.9	85.8	1.0
	O	C:PHE133	2.9	93.9	1.0
	O	D:PHE133	2.9	92.5	1.0
	O	B:PHE133	2.9	88.3	1.0
	C	A:PHE133	3.5	74.9	1.0
	C	D:PHE133	3.5	82.3	1.0
	C	C:PHE133	3.5	85.4	1.0
	C	B:PHE133	3.5	78.1	1.0
	C	D:GLY132	3.9	108.5	1.0
	C	A:GLY132	3.9	101.8	1.0
	C	B:GLY132	3.9	102.5	1.0
	C	C:GLY132	3.9	106.0	1.0
	CA	A:PHE133	4.0	74.1	1.0
	CA	D:PHE133	4.0	81.9	1.0
	CA	C:PHE133	4.0	84.6	1.0
	CA	B:PHE133	4.0	76.8	1.0
	N	D:GLY134	4.2	84.0	1.0
	N	C:GLY134	4.2	84.3	1.0
	N	A:GLY134	4.3	83.0	1.0
	N	B:GLY134	4.3	85.2	1.0
	N	D:PHE133	4.4	82.0	1.0
	N	A:PHE133	4.5	73.2	1.0
	N	B:PHE133	4.5	76.7	1.0
	N	C:PHE133	4.5	84.0	1.0
	CA	D:GLY134	4.5	92.0	1.0
	CA	C:GLY134	4.5	91.8	1.0
	CA	B:GLY134	4.5	93.0	1.0
	CA	A:GLY134	4.5	91.3	1.0

Potassium binding site 3 out of 4 in 8ti2

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Potassium Binding Sites List in 8ti2

Potassium binding site 3 out of 4 in the Cryo-Em Structure of A SUR1/KIR6.2-Q52R Atp-Sensitive Potassium Channel in the Presence of PIP2 in the Open Conformation

Mono view

Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Cryo-Em Structure of A SUR1/KIR6.2-Q52R Atp-Sensitive Potassium Channel in the Presence of PIP2 in the Open Conformation within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:K404 b:312.0 occ:1.00	O	B:ILE131	2.8	173.6	1.0
	O	A:ILE131	2.8	179.0	1.0
	O	D:ILE131	2.8	181.5	1.0
	O	C:ILE131	2.8	167.1	1.0
	O	C:THR130	2.8	105.5	1.0
	O	B:THR130	2.8	108.0	1.0
	O	D:THR130	2.8	110.2	1.0
	O	A:THR130	2.8	111.8	1.0
	C	D:ILE131	3.6	178.6	1.0
	C	B:ILE131	3.6	170.4	1.0
	C	A:ILE131	3.6	176.0	1.0
	C	C:ILE131	3.6	163.6	1.0
	C	C:THR130	3.9	93.1	1.0
	C	B:THR130	3.9	96.2	1.0
	C	A:THR130	3.9	100.7	1.0
	C	D:THR130	3.9	98.8	1.0
	CA	B:ILE131	4.0	169.1	1.0
	CA	D:ILE131	4.0	177.0	1.0
	CA	A:ILE131	4.0	174.6	1.0
	CA	C:ILE131	4.0	161.7	1.0
	N	B:ILE131	4.4	167.0	1.0
	N	D:ILE131	4.4	175.1	1.0
	N	A:ILE131	4.4	172.7	1.0
	N	C:ILE131	4.4	159.5	1.0
	N	D:GLY132	4.6	108.9	1.0
	N	B:GLY132	4.6	101.2	1.0
	N	C:GLY132	4.6	105.4	1.0
	N	A:GLY132	4.6	101.7	1.0
	CA	D:GLY132	5.0	112.0	1.0

Potassium binding site 4 out of 4 in 8ti2

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Potassium Binding Sites List in 8ti2

Potassium binding site 4 out of 4 in the Cryo-Em Structure of A SUR1/KIR6.2-Q52R Atp-Sensitive Potassium Channel in the Presence of PIP2 in the Open Conformation

Mono view

Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Cryo-Em Structure of A SUR1/KIR6.2-Q52R Atp-Sensitive Potassium Channel in the Presence of PIP2 in the Open Conformation within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:K405 b:177.8 occ:1.00	O	A:PHE133	4.3	85.8	1.0
	O	B:PHE133	4.3	88.3	1.0
	O	D:PHE133	4.3	92.5	1.0
	O	C:PHE133	4.3	93.9	1.0
	CA	B:GLY134	5.0	93.0	1.0
	CA	C:GLY134	5.0	91.8	1.0
	CA	D:GLY134	5.0	92.0	1.0
	CA	A:GLY134	5.0	91.3	1.0

Reference:

C.M.Driggers, Y.Y.Kuo, P.Zhu, A.Elsheikh, S.L.Shyng. Structure of An Open K Atp Channel Reveals Tandem Pip 2 Binding Sites Mediating the KIR6.2 and SUR1 Regulatory Interface. Nat Commun V. 15 2502 2024.
ISSN: ESSN 2041-1723
PubMed: 38509107
DOI: 10.1038/S41467-024-46751-5

Page generated: Tue Aug 13 00:59:39 2024

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