Potassium in PDB 8ti2: Cryo-Em Structure of A SUR1/KIR6.2-Q52R Atp-Sensitive Potassium Channel in the Presence of PIP2 in the Open Conformation

Potassium Binding Sites:

The binding sites of Potassium atom in the Cryo-Em Structure of A SUR1/KIR6.2-Q52R Atp-Sensitive Potassium Channel in the Presence of PIP2 in the Open Conformation (pdb code 8ti2). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 4 binding sites of Potassium where determined in the Cryo-Em Structure of A SUR1/KIR6.2-Q52R Atp-Sensitive Potassium Channel in the Presence of PIP2 in the Open Conformation, PDB code: 8ti2:
Jump to Potassium binding site number: 1; 2; 3; 4;

Potassium binding site 1 out of 4 in 8ti2

Go back to

Potassium Binding Sites List in 8ti2

Potassium binding site 1 out of 4 in the Cryo-Em Structure of A SUR1/KIR6.2-Q52R Atp-Sensitive Potassium Channel in the Presence of PIP2 in the Open Conformation

Mono view

Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Cryo-Em Structure of A SUR1/KIR6.2-Q52R Atp-Sensitive Potassium Channel in the Presence of PIP2 in the Open Conformation within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:K402 b:124.0 occ:1.00	OG1	C:THR130	3.2	89.9	1.0
	OG1	B:THR130	3.2	93.3	1.0
	OG1	D:THR130	3.2	94.8	1.0
	OG1	A:THR130	3.2	97.6	1.0
	CB	B:THR130	4.3	92.8	1.0
	CB	C:THR130	4.3	90.3	1.0
	CB	D:THR130	4.3	95.1	1.0
	CB	A:THR130	4.3	97.4	1.0
	O	A:THR130	4.6	111.8	1.0
	O	B:THR130	4.6	108.0	1.0
	O	D:THR130	4.6	110.2	1.0
	O	C:THR130	4.6	105.5	1.0
	O	C:VAL129	4.9	90.4	1.0
	O	B:VAL129	4.9	88.8	1.0
	O	D:VAL129	4.9	90.6	1.0
	O	A:VAL129	4.9	95.5	1.0

Potassium binding site 2 out of 4 in 8ti2

Go back to

Potassium Binding Sites List in 8ti2

Potassium binding site 2 out of 4 in the Cryo-Em Structure of A SUR1/KIR6.2-Q52R Atp-Sensitive Potassium Channel in the Presence of PIP2 in the Open Conformation

Mono view

Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Cryo-Em Structure of A SUR1/KIR6.2-Q52R Atp-Sensitive Potassium Channel in the Presence of PIP2 in the Open Conformation within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:K403 b:88.0 occ:1.00	O	D:GLY132	2.7	112.5	1.0
	O	A:GLY132	2.7	106.4	1.0
	O	B:GLY132	2.7	107.5	1.0
	O	C:GLY132	2.7	110.6	1.0
	O	A:PHE133	2.9	85.8	1.0
	O	C:PHE133	2.9	93.9	1.0
	O	D:PHE133	2.9	92.5	1.0
	O	B:PHE133	2.9	88.3	1.0
	C	A:PHE133	3.5	74.9	1.0
	C	D:PHE133	3.5	82.3	1.0
	C	C:PHE133	3.5	85.4	1.0
	C	B:PHE133	3.5	78.1	1.0
	C	D:GLY132	3.9	108.5	1.0
	C	A:GLY132	3.9	101.8	1.0
	C	B:GLY132	3.9	102.5	1.0
	C	C:GLY132	3.9	106.0	1.0
	CA	A:PHE133	4.0	74.1	1.0
	CA	D:PHE133	4.0	81.9	1.0
	CA	C:PHE133	4.0	84.6	1.0
	CA	B:PHE133	4.0	76.8	1.0
	N	D:GLY134	4.2	84.0	1.0
	N	C:GLY134	4.2	84.3	1.0
	N	A:GLY134	4.3	83.0	1.0
	N	B:GLY134	4.3	85.2	1.0
	N	D:PHE133	4.4	82.0	1.0
	N	A:PHE133	4.5	73.2	1.0
	N	B:PHE133	4.5	76.7	1.0
	N	C:PHE133	4.5	84.0	1.0
	CA	D:GLY134	4.5	92.0	1.0
	CA	C:GLY134	4.5	91.8	1.0
	CA	B:GLY134	4.5	93.0	1.0
	CA	A:GLY134	4.5	91.3	1.0

Potassium binding site 3 out of 4 in 8ti2

Go back to

Potassium Binding Sites List in 8ti2

Potassium binding site 3 out of 4 in the Cryo-Em Structure of A SUR1/KIR6.2-Q52R Atp-Sensitive Potassium Channel in the Presence of PIP2 in the Open Conformation

Mono view

Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Cryo-Em Structure of A SUR1/KIR6.2-Q52R Atp-Sensitive Potassium Channel in the Presence of PIP2 in the Open Conformation within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:K404 b:312.0 occ:1.00	O	B:ILE131	2.8	173.6	1.0
	O	A:ILE131	2.8	179.0	1.0
	O	D:ILE131	2.8	181.5	1.0
	O	C:ILE131	2.8	167.1	1.0
	O	C:THR130	2.8	105.5	1.0
	O	B:THR130	2.8	108.0	1.0
	O	D:THR130	2.8	110.2	1.0
	O	A:THR130	2.8	111.8	1.0
	C	D:ILE131	3.6	178.6	1.0
	C	B:ILE131	3.6	170.4	1.0
	C	A:ILE131	3.6	176.0	1.0
	C	C:ILE131	3.6	163.6	1.0
	C	C:THR130	3.9	93.1	1.0
	C	B:THR130	3.9	96.2	1.0
	C	A:THR130	3.9	100.7	1.0
	C	D:THR130	3.9	98.8	1.0
	CA	B:ILE131	4.0	169.1	1.0
	CA	D:ILE131	4.0	177.0	1.0
	CA	A:ILE131	4.0	174.6	1.0
	CA	C:ILE131	4.0	161.7	1.0
	N	B:ILE131	4.4	167.0	1.0
	N	D:ILE131	4.4	175.1	1.0
	N	A:ILE131	4.4	172.7	1.0
	N	C:ILE131	4.4	159.5	1.0
	N	D:GLY132	4.6	108.9	1.0
	N	B:GLY132	4.6	101.2	1.0
	N	C:GLY132	4.6	105.4	1.0
	N	A:GLY132	4.6	101.7	1.0
	CA	D:GLY132	5.0	112.0	1.0

Potassium binding site 4 out of 4 in 8ti2

Go back to

Potassium Binding Sites List in 8ti2

Potassium binding site 4 out of 4 in the Cryo-Em Structure of A SUR1/KIR6.2-Q52R Atp-Sensitive Potassium Channel in the Presence of PIP2 in the Open Conformation

Mono view

Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Cryo-Em Structure of A SUR1/KIR6.2-Q52R Atp-Sensitive Potassium Channel in the Presence of PIP2 in the Open Conformation within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:K405 b:177.8 occ:1.00	O	A:PHE133	4.3	85.8	1.0
	O	B:PHE133	4.3	88.3	1.0
	O	D:PHE133	4.3	92.5	1.0
	O	C:PHE133	4.3	93.9	1.0
	CA	B:GLY134	5.0	93.0	1.0
	CA	C:GLY134	5.0	91.8	1.0
	CA	D:GLY134	5.0	92.0	1.0
	CA	A:GLY134	5.0	91.3	1.0

Reference:

C.M.Driggers, Y.Y.Kuo, P.Zhu, A.Elsheikh, S.L.Shyng. Structure of An Open K Atp Channel Reveals Tandem Pip 2 Binding Sites Mediating the KIR6.2 and SUR1 Regulatory Interface. Nat Commun V. 15 2502 2024.
ISSN: ESSN 2041-1723
PubMed: 38509107
DOI: 10.1038/S41467-024-46751-5

Page generated: Tue Aug 13 00:59:39 2024

Last articles

Mg in 4Y52
Mg in 4Y30
Mg in 4Y2V
Mg in 4Y2X
Mg in 4Y2Y
Mg in 4Y2U
Mg in 4Y2T
Mg in 4Y2Q
Mg in 4Y2R
Mg in 4Y2S

	© Copyright 2008-2020 by atomistry.com
Home \| Site Map \| Copyright \| Contact us \| Privacy