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Potassium in PDB 8qz1: Crystal Structure of Human Two Pore Domain Potassium Ion Channel Trek- 2 (K2P10.1) in Complex with A Nanobody (NB58)
Protein crystallography data
The structure of Crystal Structure of Human Two Pore Domain Potassium Ion Channel Trek- 2 (K2P10.1) in Complex with A Nanobody (NB58), PDB code: 8qz1
was solved by
K.E.J.Rodstrom,
A.C.W.Pike,
A.Baronina,
J.Ang,
S.R.Bushell,
R.Chalk,
S.M.M.Mukhopadhyay,
E.Pardon,
C.H.Arrowsmith,
A.M.Edwards,
C.Bountra,
N.A.Burgess-Brown,
S.J.Tucker,
J.Steyaert,
E.P.Carpenter,
Structuralgenomics Consortium (Sgc),
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 30.84 / 3.59 |
| Space group | H 3 |
| Cell size a, b, c (Å), α, β, γ (°) | 233.663, 233.663, 67.388, 90, 90, 120 |
| R / Rfree (%) | 25.6 / 29.8 |
Potassium Binding Sites:
The binding sites of Potassium atom in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel Trek- 2 (K2P10.1) in Complex with A Nanobody (NB58)
(pdb code 8qz1). This binding sites where shown within
5.0 Angstroms radius around Potassium atom.
In total 3 binding sites of Potassium where determined in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel Trek- 2 (K2P10.1) in Complex with A Nanobody (NB58), PDB code: 8qz1:
Jump to Potassium binding site number: 1; 2; 3;
In total 3 binding sites of Potassium where determined in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel Trek- 2 (K2P10.1) in Complex with A Nanobody (NB58), PDB code: 8qz1:
Jump to Potassium binding site number: 1; 2; 3;
Potassium binding site 1 out of 3 in 8qz1
Go back to
Potassium Binding Sites List in 8qz1
Potassium binding site 1 out
of 3 in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel Trek- 2 (K2P10.1) in Complex with A Nanobody (NB58)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 1 of Crystal Structure of Human Two Pore Domain Potassium Ion Channel Trek- 2 (K2P10.1) in Complex with A Nanobody (NB58) within 5.0Å range:
|
Potassium binding site 2 out of 3 in 8qz1
Go back to
Potassium Binding Sites List in 8qz1
Potassium binding site 2 out
of 3 in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel Trek- 2 (K2P10.1) in Complex with A Nanobody (NB58)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 2 of Crystal Structure of Human Two Pore Domain Potassium Ion Channel Trek- 2 (K2P10.1) in Complex with A Nanobody (NB58) within 5.0Å range:
|
Potassium binding site 3 out of 3 in 8qz1
Go back to
Potassium Binding Sites List in 8qz1
Potassium binding site 3 out
of 3 in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel Trek- 2 (K2P10.1) in Complex with A Nanobody (NB58)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 3 of Crystal Structure of Human Two Pore Domain Potassium Ion Channel Trek- 2 (K2P10.1) in Complex with A Nanobody (NB58) within 5.0Å range:
|
Reference:
K.E.J.Rodstrom,
A.Cloake,
J.Sormann,
A.Baronina,
K.H.M.Smith,
A.C.W.Pike,
J.Ang,
P.Proks,
M.Schewe,
I.Holland-Kaye,
S.R.Bushell,
J.Elliott,
E.Pardon,
T.Baukrowitz,
R.J.Owens,
S.Newstead,
J.Steyaert,
E.P.Carpenter,
S.J.Tucker.
Extracellular Modulation of Trek-2 Activity with Nanobodies Provides Insight Into the Mechanisms of K2P Channel Regulation. Nat Commun V. 15 4173 2024.
ISSN: ESSN 2041-1723
PubMed: 38755204
DOI: 10.1038/S41467-024-48536-2
Page generated: Tue Aug 13 00:37:48 2024
ISSN: ESSN 2041-1723
PubMed: 38755204
DOI: 10.1038/S41467-024-48536-2
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