Potassium in PDB 8egf: Branched Chain Ketoacid Dehydrogenase Kinase in Complex with Inhibitor

All present enzymatic activity of Branched Chain Ketoacid Dehydrogenase Kinase in Complex with Inhibitor:
2.7.11.4;

The structure of Branched Chain Ketoacid Dehydrogenase Kinase in Complex with Inhibitor, PDB code: 8egf was solved by S.Liu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.49 / 1.85
Space group	P 64 2 2
Cell size a, b, c (Å), α, β, γ (°)	111.401, 111.401, 140.547, 90, 90, 120
R / Rfree (%)	22.1 / 25

The binding sites of Potassium atom in the Branched Chain Ketoacid Dehydrogenase Kinase in Complex with Inhibitor (pdb code 8egf). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Branched Chain Ketoacid Dehydrogenase Kinase in Complex with Inhibitor, PDB code: 8egf:

Potassium binding site 1 out of 1 in the Branched Chain Ketoacid Dehydrogenase Kinase in Complex with Inhibitor


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Branched Chain Ketoacid Dehydrogenase Kinase in Complex with Inhibitor within 5.0Å range: probe atom residue distance (Å) B Occ A:K402 b:65.1 occ:1.00 O A:PHE303 2.7 44.4 1.0 O2A A:ADP401 2.7 34.7 1.0 O A:VAL298 2.7 39.5 1.0 O A:ASP300 2.9 38.7 1.0 O A:GLY337 2.9 39.5 1.0 C5' A:ADP401 3.5 38.5 1.0 C A:GLY337 3.5 41.1 1.0 CD A:PRO341 3.6 32.9 1.0 CA A:GLY337 3.7 40.0 1.0 C A:VAL298 3.8 39.9 1.0 C A:PHE303 3.8 45.6 1.0 PA A:ADP401 3.9 36.9 1.0 C A:ASP300 4.0 40.4 1.0 N A:PHE303 4.0 44.2 1.0 O5' A:ADP401 4.1 35.7 1.0 CA A:PHE303 4.2 42.4 1.0 CG A:PRO341 4.2 37.0 1.0 O3A A:ADP401 4.2 38.5 1.0 CB A:PHE303 4.2 43.0 1.0 CA A:VAL298 4.4 38.8 1.0 N A:ASP300 4.4 39.2 1.0 N A:PHE338 4.6 39.4 1.0 CB A:LEU340 4.7 30.7 1.0 O A:ARG297 4.7 44.4 1.0 N A:MET299 4.7 36.1 1.0 N A:HIS302 4.8 44.2 1.0 C A:MET299 4.8 41.2 1.0 CD1 A:PHE303 4.8 46.4 1.0 C4' A:ADP401 4.8 39.7 1.0 CA A:ASP300 4.9 39.2 1.0 N A:TYR301 4.9 37.8 1.0 N A:LEU340 4.9 31.1 1.0 CA A:TYR301 4.9 38.0 1.0 N A:PRO341 4.9 31.8 1.0 C A:HIS302 5.0 50.0 1.0 N A:THR304 5.0 42.3 1.0 CA A:MET299 5.0 36.1 1.0

S.Liu, B.L.Kormos, J.D.Knafels, P.V.Sahasrabudhe, A.Rosado, R.F.Sommese, A.R.Reyes, J.Ward, R.J.Roth Flach, X.Wang, L.M.Buzon, M.R.Reese, S.K.Bhattacharya, K.Omoto, K.J.Filipski. Structural Studies Identify Angiotensin II Receptor Blocker-Like Compounds As Branched-Chain Ketoacid Dehydrogenase Kinase Inhibitors. J.Biol.Chem. V. 299 02959 2023.
ISSN: ESSN 1083-351X
PubMed: 36717078
DOI: 10.1016/J.JBC.2023.102959