Potassium in PDB 8dhm: Human TMEM175 in Complex with 4-Aminopyridine

The binding sites of Potassium atom in the Human TMEM175 in Complex with 4-Aminopyridine (pdb code 8dhm). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 4 binding sites of Potassium where determined in the Human TMEM175 in Complex with 4-Aminopyridine, PDB code: 8dhm:
Jump to Potassium binding site number: 1; 2; 3; 4;

Potassium binding site 1 out of 4 in the Human TMEM175 in Complex with 4-Aminopyridine


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Human TMEM175 in Complex with 4-Aminopyridine within 5.0Å range: probe atom residue distance (Å) B Occ B:K701 b:40.3 occ:1.00 K A:K701 2.8 39.9 1.0 HB3 B:SER38 3.0 12.1 1.0 HB2 B:ALA263 3.1 11.7 1.0 O B:HOH816 3.3 11.3 1.0 OG B:SER38 3.3 12.1 1.0 HB1 B:ALA263 3.3 11.7 1.0 HG B:SER38 3.4 12.1 1.0 CB B:SER38 3.6 12.1 1.0 CB B:ALA263 3.6 11.7 1.0 HA B:SER38 4.0 12.1 1.0 HA B:ALA263 4.1 11.7 1.0 O B:HOH841 4.1 10.2 1.0 HB3 A:SER38 4.2 12.1 1.0 CA B:SER38 4.4 12.1 1.0 HB2 B:SER38 4.4 12.1 1.0 HB3 B:ALA263 4.4 11.7 1.0 O B:HOH837 4.5 15.9 1.0 CA B:ALA263 4.5 11.7 1.0 O A:HOH840 4.5 10.0 1.0 HG A:SER38 4.5 12.1 1.0 O B:HOH817 4.5 9.1 1.0 O A:HOH816 4.8 11.2 1.0 OG A:SER38 4.8 12.1 1.0 CB A:SER38 4.9 12.1 1.0

Potassium binding site 2 out of 4 in the Human TMEM175 in Complex with 4-Aminopyridine


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Human TMEM175 in Complex with 4-Aminopyridine within 5.0Å range: probe atom residue distance (Å) B Occ B:K702 b:43.1 occ:1.00 K A:K702 2.9 42.9 1.0 HD11 B:LEU53 3.0 20.8 1.0 O B:HOH843 3.0 22.1 1.0 HD21 B:LEU53 3.0 20.8 1.0 HD13 A:LEU278 3.2 17.0 1.0 O B:HOH845 3.2 13.5 1.0 HD13 B:LEU53 3.5 20.8 1.0 O B:HOH846 3.5 14.0 1.0 CD1 B:LEU53 3.6 20.8 1.0 HD11 A:LEU278 3.7 17.0 1.0 HD13 B:LEU278 3.8 17.0 1.0 CD2 B:LEU53 3.9 20.8 1.0 CD1 A:LEU278 3.9 17.0 1.0 O B:HOH821 4.1 10.0 1.0 HD22 B:LEU53 4.1 20.8 1.0 HD12 B:LEU278 4.2 17.0 1.0 CG B:LEU53 4.2 20.8 1.0 CD1 B:LEU278 4.3 17.0 1.0 O A:HOH845 4.3 13.9 1.0 HD11 B:LEU278 4.3 17.0 1.0 HG B:LEU53 4.4 20.8 1.0 HD12 B:LEU275 4.4 15.5 1.0 HD12 A:LEU278 4.4 17.0 1.0 O A:HOH842 4.4 22.0 1.0 HD12 B:LEU53 4.4 20.8 1.0 HD22 A:LEU278 4.6 17.0 1.0 HD23 B:LEU53 4.6 20.8 1.0 HD11 B:LEU275 4.7 15.5 1.0 HG23 B:ILE271 4.7 10.6 1.0 O A:HOH844 4.8 13.7 1.0 HD21 A:LEU278 4.9 17.0 1.0 HB3 A:LEU278 5.0 17.0 1.0

Potassium binding site 3 out of 4 in the Human TMEM175 in Complex with 4-Aminopyridine


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Human TMEM175 in Complex with 4-Aminopyridine within 5.0Å range: probe atom residue distance (Å) B Occ A:K701 b:39.9 occ:1.00 K B:K701 2.8 40.3 1.0 HB3 A:SER38 3.0 12.1 1.0 HB2 A:ALA263 3.1 11.7 1.0 O A:HOH816 3.3 11.2 1.0 OG A:SER38 3.3 12.1 1.0 HB1 A:ALA263 3.3 11.7 1.0 HG A:SER38 3.4 12.1 1.0 CB A:SER38 3.6 12.1 1.0 CB A:ALA263 3.6 11.7 1.0 HA A:SER38 4.0 12.1 1.0 HA A:ALA263 4.1 11.7 1.0 O A:HOH840 4.2 10.0 1.0 HB3 B:SER38 4.2 12.1 1.0 CA A:SER38 4.4 12.1 1.0 HB2 A:SER38 4.4 12.1 1.0 HB3 A:ALA263 4.4 11.7 1.0 O A:HOH836 4.5 15.9 1.0 CA A:ALA263 4.5 11.7 1.0 O B:HOH841 4.5 10.2 1.0 O A:HOH817 4.5 9.0 1.0 HG B:SER38 4.5 12.1 1.0 OG B:SER38 4.8 12.1 1.0 O B:HOH816 4.8 11.3 1.0 CB B:SER38 4.9 12.1 1.0

Potassium binding site 4 out of 4 in the Human TMEM175 in Complex with 4-Aminopyridine


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Human TMEM175 in Complex with 4-Aminopyridine within 5.0Å range: probe atom residue distance (Å) B Occ A:K702 b:42.9 occ:1.00 K B:K702 2.9 43.1 1.0 HD11 A:LEU53 2.9 20.9 1.0 O A:HOH842 3.0 22.0 1.0 HD21 A:LEU53 3.0 20.9 1.0 HD13 B:LEU278 3.2 17.0 1.0 O A:HOH844 3.2 13.7 1.0 HD13 A:LEU53 3.5 20.9 1.0 O A:HOH845 3.5 13.9 1.0 CD1 A:LEU53 3.6 20.9 1.0 HD11 B:LEU278 3.7 17.0 1.0 HD13 A:LEU278 3.8 17.0 1.0 CD2 A:LEU53 3.9 20.9 1.0 CD1 B:LEU278 3.9 17.0 1.0 O A:HOH821 4.1 10.0 1.0 HD22 A:LEU53 4.1 20.9 1.0 HD12 A:LEU278 4.2 17.0 1.0 CG A:LEU53 4.2 20.9 1.0 CD1 A:LEU278 4.3 17.0 1.0 O B:HOH846 4.3 14.0 1.0 HD11 A:LEU278 4.3 17.0 1.0 HG A:LEU53 4.4 20.9 1.0 HD12 A:LEU275 4.4 15.5 1.0 HD12 B:LEU278 4.4 17.0 1.0 O B:HOH843 4.4 22.1 1.0 HD12 A:LEU53 4.4 20.9 1.0 HD22 B:LEU278 4.6 17.0 1.0 HD23 A:LEU53 4.6 20.9 1.0 HD11 A:LEU275 4.7 15.5 1.0 HG23 A:ILE271 4.7 10.6 1.0 O B:HOH845 4.8 13.5 1.0 HD21 B:LEU278 4.9 17.0 1.0 CD1 A:LEU275 5.0 15.5 1.0

S.Oh, R.Stix, W.Zhou, J.D.Faraldo-Gomez, R.K.Hite. Mechanism of 4-Aminopyridine Inhibition of the Lysosomal Channel TMEM175. Proc.Natl.Acad.Sci.Usa V. 119 82119 2022.
ISSN: ESSN 1091-6490
PubMed: 36279431
DOI: 10.1073/PNAS.2208882119