Potassium in PDB 8de9: Cryo-Em Structure of the Zebrafish Two Pore Domain K+ Channel TREK1 (K2P2.1) in Ddm/Pope Mixed Micelles

The binding sites of Potassium atom in the Cryo-Em Structure of the Zebrafish Two Pore Domain K+ Channel TREK1 (K2P2.1) in Ddm/Pope Mixed Micelles (pdb code 8de9). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 3 binding sites of Potassium where determined in the Cryo-Em Structure of the Zebrafish Two Pore Domain K+ Channel TREK1 (K2P2.1) in Ddm/Pope Mixed Micelles, PDB code: 8de9:
Jump to Potassium binding site number: 1; 2; 3;

Potassium binding site 1 out of 3 in the Cryo-Em Structure of the Zebrafish Two Pore Domain K+ Channel TREK1 (K2P2.1) in Ddm/Pope Mixed Micelles


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Cryo-Em Structure of the Zebrafish Two Pore Domain K+ Channel TREK1 (K2P2.1) in Ddm/Pope Mixed Micelles within 5.0Å range: probe atom residue distance (Å) B Occ A:K402 b:31.5 occ:1.00 O B:THR142 2.9 41.7 1.0 O A:THR142 3.0 41.8 1.0 O A:THR251 3.1 42.0 1.0 K A:K403 3.1 54.7 1.0 O B:THR251 3.1 43.8 1.0 OG1 A:THR251 3.1 42.0 1.0 OG1 B:THR142 3.3 41.7 1.0 OG1 A:THR142 3.4 41.8 1.0 OG1 B:THR251 3.6 43.8 1.0 CB A:THR251 3.6 42.0 1.0 CB B:THR142 3.8 41.7 1.0 CB A:THR142 3.9 41.8 1.0 CB B:THR251 4.0 43.8 1.0 C B:THR142 4.0 41.7 1.0 C A:THR251 4.1 42.0 1.0 C A:THR142 4.1 41.8 1.0 C B:THR251 4.2 43.8 1.0 CA A:THR251 4.5 42.0 1.0 CA B:THR142 4.6 41.7 1.0 CA A:THR142 4.7 41.8 1.0 CA B:THR251 4.7 43.8 1.0 CG2 A:THR251 4.8 42.0 1.0 C33 A:PEV401 5.0 63.2 1.0

Potassium binding site 2 out of 3 in the Cryo-Em Structure of the Zebrafish Two Pore Domain K+ Channel TREK1 (K2P2.1) in Ddm/Pope Mixed Micelles


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Cryo-Em Structure of the Zebrafish Two Pore Domain K+ Channel TREK1 (K2P2.1) in Ddm/Pope Mixed Micelles within 5.0Å range: probe atom residue distance (Å) B Occ A:K403 b:54.7 occ:1.00 O A:ILE143 2.9 37.7 1.0 O A:THR142 2.9 41.8 1.0 O B:ILE252 3.0 41.6 1.0 O A:THR251 3.0 42.0 1.0 O B:THR142 3.0 41.7 1.0 O B:ILE143 3.0 41.6 1.0 K A:K402 3.1 31.5 1.0 O A:ILE252 3.1 37.7 1.0 K A:K404 3.1 44.7 1.0 O B:THR251 3.2 43.8 1.0 C B:ILE252 3.8 41.6 1.0 C A:ILE143 3.8 37.7 1.0 C B:ILE143 3.9 41.6 1.0 C A:ILE252 3.9 37.7 1.0 C A:THR142 4.0 41.8 1.0 C B:THR142 4.1 41.7 1.0 C B:THR251 4.1 43.8 1.0 C A:THR251 4.1 42.0 1.0 CA A:ILE143 4.2 37.7 1.0 CA B:ILE143 4.3 41.6 1.0 CA B:ILE252 4.3 41.6 1.0 CA A:ILE252 4.4 37.7 1.0 N A:ILE143 4.6 37.7 1.0 N B:ILE252 4.6 41.6 1.0 N B:ILE143 4.7 41.6 1.0 N B:GLY253 4.7 43.8 1.0 N A:ILE252 4.8 37.7 1.0 N A:GLY144 4.8 42.4 1.0 N A:GLY253 4.8 40.1 1.0 N B:GLY144 4.9 45.4 1.0

Potassium binding site 3 out of 3 in the Cryo-Em Structure of the Zebrafish Two Pore Domain K+ Channel TREK1 (K2P2.1) in Ddm/Pope Mixed Micelles


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Cryo-Em Structure of the Zebrafish Two Pore Domain K+ Channel TREK1 (K2P2.1) in Ddm/Pope Mixed Micelles within 5.0Å range: probe atom residue distance (Å) B Occ A:K404 b:44.7 occ:1.00 O B:ILE143 2.7 41.6 1.0 O A:ILE143 2.7 37.7 1.0 O A:GLY253 2.7 40.1 1.0 O B:ILE252 2.8 41.6 1.0 O A:GLY144 2.8 42.4 1.0 O A:ILE252 2.8 37.7 1.0 O B:GLY144 2.8 45.4 1.0 O B:GLY253 2.8 43.8 1.0 K A:K403 3.1 54.7 1.0 C A:GLY253 3.6 40.1 1.0 C B:GLY253 3.6 43.8 1.0 C A:GLY144 3.7 42.4 1.0 C B:GLY144 3.7 45.4 1.0 CA A:GLY253 3.8 40.1 1.0 CA B:GLY253 3.8 43.8 1.0 C B:ILE252 3.9 41.6 1.0 C B:ILE143 3.9 41.6 1.0 C A:ILE252 3.9 37.7 1.0 C A:ILE143 3.9 37.7 1.0 CA B:GLY144 4.0 45.4 1.0 CA A:GLY144 4.1 42.4 1.0 N B:GLY253 4.3 43.8 1.0 N A:GLY253 4.3 40.1 1.0 N B:GLY144 4.4 45.4 1.0 N A:GLY144 4.5 42.4 1.0 N A:PHE254 4.8 45.6 1.0 N B:PHE254 4.8 47.1 1.0 N A:PHE145 4.8 45.5 1.0 N B:PHE145 4.8 50.2 1.0

P.A.M.Schmidpeter, J.T.Petroff 2Nd, L.Khajoueinejad, A.Wague, C.Frankfater, W.W.L.Cheng, C.M.Nimigean, P.M.Riegelhaupt. Membrane Phospholipids Control Gating of the Mechanosensitive Potassium Leak Channel TREK1. Nat Commun V. 14 1077 2023.
ISSN: ESSN 2041-1723
PubMed: 36841877
DOI: 10.1038/S41467-023-36765-W