Potassium in PDB 8de9: Cryo-Em Structure of the Zebrafish Two Pore Domain K+ Channel TREK1 (K2P2.1) in Ddm/Pope Mixed Micelles
Potassium Binding Sites:
The binding sites of Potassium atom in the Cryo-Em Structure of the Zebrafish Two Pore Domain K+ Channel TREK1 (K2P2.1) in Ddm/Pope Mixed Micelles
(pdb code 8de9). This binding sites where shown within
5.0 Angstroms radius around Potassium atom.
In total 3 binding sites of Potassium where determined in the
Cryo-Em Structure of the Zebrafish Two Pore Domain K+ Channel TREK1 (K2P2.1) in Ddm/Pope Mixed Micelles, PDB code: 8de9:
Jump to Potassium binding site number:
1;
2;
3;
Potassium binding site 1 out
of 3 in 8de9
Go back to
Potassium Binding Sites List in 8de9
Potassium binding site 1 out
of 3 in the Cryo-Em Structure of the Zebrafish Two Pore Domain K+ Channel TREK1 (K2P2.1) in Ddm/Pope Mixed Micelles
Mono view
Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 1 of Cryo-Em Structure of the Zebrafish Two Pore Domain K+ Channel TREK1 (K2P2.1) in Ddm/Pope Mixed Micelles within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K402
b:31.5
occ:1.00
|
O
|
B:THR142
|
2.9
|
41.7
|
1.0
|
O
|
A:THR142
|
3.0
|
41.8
|
1.0
|
O
|
A:THR251
|
3.1
|
42.0
|
1.0
|
K
|
A:K403
|
3.1
|
54.7
|
1.0
|
O
|
B:THR251
|
3.1
|
43.8
|
1.0
|
OG1
|
A:THR251
|
3.1
|
42.0
|
1.0
|
OG1
|
B:THR142
|
3.3
|
41.7
|
1.0
|
OG1
|
A:THR142
|
3.4
|
41.8
|
1.0
|
OG1
|
B:THR251
|
3.6
|
43.8
|
1.0
|
CB
|
A:THR251
|
3.6
|
42.0
|
1.0
|
CB
|
B:THR142
|
3.8
|
41.7
|
1.0
|
CB
|
A:THR142
|
3.9
|
41.8
|
1.0
|
CB
|
B:THR251
|
4.0
|
43.8
|
1.0
|
C
|
B:THR142
|
4.0
|
41.7
|
1.0
|
C
|
A:THR251
|
4.1
|
42.0
|
1.0
|
C
|
A:THR142
|
4.1
|
41.8
|
1.0
|
C
|
B:THR251
|
4.2
|
43.8
|
1.0
|
CA
|
A:THR251
|
4.5
|
42.0
|
1.0
|
CA
|
B:THR142
|
4.6
|
41.7
|
1.0
|
CA
|
A:THR142
|
4.7
|
41.8
|
1.0
|
CA
|
B:THR251
|
4.7
|
43.8
|
1.0
|
CG2
|
A:THR251
|
4.8
|
42.0
|
1.0
|
C33
|
A:PEV401
|
5.0
|
63.2
|
1.0
|
|
Potassium binding site 2 out
of 3 in 8de9
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Potassium Binding Sites List in 8de9
Potassium binding site 2 out
of 3 in the Cryo-Em Structure of the Zebrafish Two Pore Domain K+ Channel TREK1 (K2P2.1) in Ddm/Pope Mixed Micelles
Mono view
Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 2 of Cryo-Em Structure of the Zebrafish Two Pore Domain K+ Channel TREK1 (K2P2.1) in Ddm/Pope Mixed Micelles within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K403
b:54.7
occ:1.00
|
O
|
A:ILE143
|
2.9
|
37.7
|
1.0
|
O
|
A:THR142
|
2.9
|
41.8
|
1.0
|
O
|
B:ILE252
|
3.0
|
41.6
|
1.0
|
O
|
A:THR251
|
3.0
|
42.0
|
1.0
|
O
|
B:THR142
|
3.0
|
41.7
|
1.0
|
O
|
B:ILE143
|
3.0
|
41.6
|
1.0
|
K
|
A:K402
|
3.1
|
31.5
|
1.0
|
O
|
A:ILE252
|
3.1
|
37.7
|
1.0
|
K
|
A:K404
|
3.1
|
44.7
|
1.0
|
O
|
B:THR251
|
3.2
|
43.8
|
1.0
|
C
|
B:ILE252
|
3.8
|
41.6
|
1.0
|
C
|
A:ILE143
|
3.8
|
37.7
|
1.0
|
C
|
B:ILE143
|
3.9
|
41.6
|
1.0
|
C
|
A:ILE252
|
3.9
|
37.7
|
1.0
|
C
|
A:THR142
|
4.0
|
41.8
|
1.0
|
C
|
B:THR142
|
4.1
|
41.7
|
1.0
|
C
|
B:THR251
|
4.1
|
43.8
|
1.0
|
C
|
A:THR251
|
4.1
|
42.0
|
1.0
|
CA
|
A:ILE143
|
4.2
|
37.7
|
1.0
|
CA
|
B:ILE143
|
4.3
|
41.6
|
1.0
|
CA
|
B:ILE252
|
4.3
|
41.6
|
1.0
|
CA
|
A:ILE252
|
4.4
|
37.7
|
1.0
|
N
|
A:ILE143
|
4.6
|
37.7
|
1.0
|
N
|
B:ILE252
|
4.6
|
41.6
|
1.0
|
N
|
B:ILE143
|
4.7
|
41.6
|
1.0
|
N
|
B:GLY253
|
4.7
|
43.8
|
1.0
|
N
|
A:ILE252
|
4.8
|
37.7
|
1.0
|
N
|
A:GLY144
|
4.8
|
42.4
|
1.0
|
N
|
A:GLY253
|
4.8
|
40.1
|
1.0
|
N
|
B:GLY144
|
4.9
|
45.4
|
1.0
|
|
Potassium binding site 3 out
of 3 in 8de9
Go back to
Potassium Binding Sites List in 8de9
Potassium binding site 3 out
of 3 in the Cryo-Em Structure of the Zebrafish Two Pore Domain K+ Channel TREK1 (K2P2.1) in Ddm/Pope Mixed Micelles
Mono view
Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 3 of Cryo-Em Structure of the Zebrafish Two Pore Domain K+ Channel TREK1 (K2P2.1) in Ddm/Pope Mixed Micelles within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K404
b:44.7
occ:1.00
|
O
|
B:ILE143
|
2.7
|
41.6
|
1.0
|
O
|
A:ILE143
|
2.7
|
37.7
|
1.0
|
O
|
A:GLY253
|
2.7
|
40.1
|
1.0
|
O
|
B:ILE252
|
2.8
|
41.6
|
1.0
|
O
|
A:GLY144
|
2.8
|
42.4
|
1.0
|
O
|
A:ILE252
|
2.8
|
37.7
|
1.0
|
O
|
B:GLY144
|
2.8
|
45.4
|
1.0
|
O
|
B:GLY253
|
2.8
|
43.8
|
1.0
|
K
|
A:K403
|
3.1
|
54.7
|
1.0
|
C
|
A:GLY253
|
3.6
|
40.1
|
1.0
|
C
|
B:GLY253
|
3.6
|
43.8
|
1.0
|
C
|
A:GLY144
|
3.7
|
42.4
|
1.0
|
C
|
B:GLY144
|
3.7
|
45.4
|
1.0
|
CA
|
A:GLY253
|
3.8
|
40.1
|
1.0
|
CA
|
B:GLY253
|
3.8
|
43.8
|
1.0
|
C
|
B:ILE252
|
3.9
|
41.6
|
1.0
|
C
|
B:ILE143
|
3.9
|
41.6
|
1.0
|
C
|
A:ILE252
|
3.9
|
37.7
|
1.0
|
C
|
A:ILE143
|
3.9
|
37.7
|
1.0
|
CA
|
B:GLY144
|
4.0
|
45.4
|
1.0
|
CA
|
A:GLY144
|
4.1
|
42.4
|
1.0
|
N
|
B:GLY253
|
4.3
|
43.8
|
1.0
|
N
|
A:GLY253
|
4.3
|
40.1
|
1.0
|
N
|
B:GLY144
|
4.4
|
45.4
|
1.0
|
N
|
A:GLY144
|
4.5
|
42.4
|
1.0
|
N
|
A:PHE254
|
4.8
|
45.6
|
1.0
|
N
|
B:PHE254
|
4.8
|
47.1
|
1.0
|
N
|
A:PHE145
|
4.8
|
45.5
|
1.0
|
N
|
B:PHE145
|
4.8
|
50.2
|
1.0
|
|
Reference:
P.A.M.Schmidpeter,
J.T.Petroff 2Nd,
L.Khajoueinejad,
A.Wague,
C.Frankfater,
W.W.L.Cheng,
C.M.Nimigean,
P.M.Riegelhaupt.
Membrane Phospholipids Control Gating of the Mechanosensitive Potassium Leak Channel TREK1. Nat Commun V. 14 1077 2023.
ISSN: ESSN 2041-1723
PubMed: 36841877
DOI: 10.1038/S41467-023-36765-W
Page generated: Wed Apr 5 10:43:01 2023
|