Potassium in PDB 8de8: Cryo-Em Structure of the Zebrafish Two Pore Domain K+ Channel TREK1 (K2P2.1) in Ddm/Popa Mixed Micelles

Potassium Binding Sites:

The binding sites of Potassium atom in the Cryo-Em Structure of the Zebrafish Two Pore Domain K+ Channel TREK1 (K2P2.1) in Ddm/Popa Mixed Micelles (pdb code 8de8). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 4 binding sites of Potassium where determined in the Cryo-Em Structure of the Zebrafish Two Pore Domain K+ Channel TREK1 (K2P2.1) in Ddm/Popa Mixed Micelles, PDB code: 8de8:
Jump to Potassium binding site number: 1; 2; 3; 4;

Potassium binding site 1 out of 4 in 8de8

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Potassium binding site 1 out of 4 in the Cryo-Em Structure of the Zebrafish Two Pore Domain K+ Channel TREK1 (K2P2.1) in Ddm/Popa Mixed Micelles


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Cryo-Em Structure of the Zebrafish Two Pore Domain K+ Channel TREK1 (K2P2.1) in Ddm/Popa Mixed Micelles within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K403

b:34.8
occ:1.00
 O A:THR142 3.2 37.8 1.0
O B:THR142 3.2 37.8 1.0
OG1 A:THR142 3.2 37.8 1.0
OG1 B:THR142 3.2 37.8 1.0
OG1 A:THR251 3.3 37.8 1.0
OG1 B:THR251 3.3 37.8 1.0
O A:THR251 3.4 37.8 1.0
O B:THR251 3.4 37.8 1.0
CB A:THR251 3.7 37.8 1.0
K A:K404 3.7 37.8 1.0
CB B:THR251 3.7 37.8 1.0
CB A:THR142 3.8 37.8 1.0
CB B:THR142 3.8 37.8 1.0
C A:THR142 4.1 37.8 1.0
C B:THR142 4.1 37.8 1.0
C A:THR251 4.2 37.8 1.0
C B:THR251 4.2 37.8 1.0
CA A:THR251 4.6 37.8 1.0
CA B:THR251 4.7 37.8 1.0
CA A:THR142 4.7 37.8 1.0
CA B:THR142 4.7 37.8 1.0
CG2 A:THR251 4.8 37.8 1.0
CG2 B:THR251 4.8 37.8 1.0
CG2 A:THR142 5.0 37.8 1.0
CG2 B:THR142 5.0 37.8 1.0

Potassium binding site 2 out of 4 in 8de8

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Potassium binding site 2 out of 4 in the Cryo-Em Structure of the Zebrafish Two Pore Domain K+ Channel TREK1 (K2P2.1) in Ddm/Popa Mixed Micelles


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Cryo-Em Structure of the Zebrafish Two Pore Domain K+ Channel TREK1 (K2P2.1) in Ddm/Popa Mixed Micelles within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K404

b:37.8
occ:1.00
 O A:THR251 2.8 37.8 1.0
O B:THR251 2.8 37.8 1.0
O A:THR142 2.9 37.8 1.0
O B:THR142 2.9 37.8 1.0
K A:K405 2.9 33.3 1.0
O A:ILE143 2.9 37.8 1.0
O B:ILE143 2.9 37.8 1.0
O A:ILE252 3.0 37.8 1.0
O B:ILE252 3.1 37.8 1.0
C A:ILE143 3.7 37.8 1.0
C B:ILE143 3.7 37.8 1.0
K A:K403 3.7 34.8 1.0
C A:ILE252 3.7 37.8 1.0
C B:ILE252 3.7 37.8 1.0
C A:THR142 4.0 37.8 1.0
C B:THR142 4.0 37.8 1.0
C A:THR251 4.0 37.8 1.0
C B:THR251 4.0 37.8 1.0
CA A:ILE143 4.1 37.8 1.0
CA B:ILE143 4.1 37.8 1.0
CA A:ILE252 4.2 37.8 1.0
CA B:ILE252 4.2 37.8 1.0
N A:ILE143 4.5 37.8 1.0
N B:ILE143 4.5 37.8 1.0
N A:GLY144 4.6 37.8 1.0
N B:GLY144 4.6 37.8 1.0
N A:ILE252 4.6 37.8 1.0
N B:ILE252 4.6 37.8 1.0
N A:GLY253 4.6 37.8 1.0
N B:GLY253 4.6 37.8 1.0
O A:GLY144 5.0 37.8 1.0
O B:GLY144 5.0 37.8 1.0
CA A:GLY144 5.0 37.8 1.0
CA B:GLY144 5.0 37.8 1.0
CA A:GLY253 5.0 37.8 1.0
CA B:GLY253 5.0 37.8 1.0

Potassium binding site 3 out of 4 in 8de8

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Potassium binding site 3 out of 4 in the Cryo-Em Structure of the Zebrafish Two Pore Domain K+ Channel TREK1 (K2P2.1) in Ddm/Popa Mixed Micelles


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Cryo-Em Structure of the Zebrafish Two Pore Domain K+ Channel TREK1 (K2P2.1) in Ddm/Popa Mixed Micelles within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K405

b:33.3
occ:1.00
 O A:GLY144 2.8 37.8 1.0
O B:GLY144 2.8 37.8 1.0
O A:ILE143 2.8 37.8 1.0
O B:ILE143 2.8 37.8 1.0
O A:GLY253 2.8 37.8 1.0
O B:GLY253 2.8 37.8 1.0
O A:ILE252 2.8 37.8 1.0
O B:ILE252 2.8 37.8 1.0
K A:K404 2.9 37.8 1.0
K A:K406 3.3 34.5 1.0
C A:GLY144 3.7 37.8 1.0
C B:GLY144 3.7 37.8 1.0
C A:GLY253 3.7 37.8 1.0
C B:GLY253 3.7 37.8 1.0
C A:ILE143 3.9 37.8 1.0
C B:ILE143 3.9 37.8 1.0
C A:ILE252 3.9 37.8 1.0
C B:ILE252 3.9 37.8 1.0
CA A:GLY144 4.1 37.8 1.0
CA B:GLY144 4.1 37.8 1.0
CA A:GLY253 4.1 37.8 1.0
CA B:GLY253 4.1 37.8 1.0
N A:GLY144 4.5 37.8 1.0
N B:GLY144 4.5 37.8 1.0
N A:GLY253 4.5 37.8 1.0
N B:GLY253 4.5 37.8 1.0
N A:PHE145 4.7 37.8 1.0
N A:PHE254 4.7 37.8 1.0
N B:PHE145 4.7 37.8 1.0
N B:PHE254 4.7 37.8 1.0
O A:THR251 5.0 37.8 1.0
O B:THR251 5.0 37.8 1.0

Potassium binding site 4 out of 4 in 8de8

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Potassium binding site 4 out of 4 in the Cryo-Em Structure of the Zebrafish Two Pore Domain K+ Channel TREK1 (K2P2.1) in Ddm/Popa Mixed Micelles


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Cryo-Em Structure of the Zebrafish Two Pore Domain K+ Channel TREK1 (K2P2.1) in Ddm/Popa Mixed Micelles within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K406

b:34.5
occ:1.00
 O A:PHE145 2.9 37.8 1.0
O B:PHE145 2.9 37.8 1.0
O B:GLY253 3.0 37.8 1.0
O B:PHE254 3.0 37.8 1.0
O A:GLY253 3.0 37.8 1.0
O A:PHE254 3.0 37.8 1.0
O A:GLY144 3.0 37.8 1.0
O B:GLY144 3.0 37.8 1.0
K A:K405 3.3 33.3 1.0
C A:PHE145 3.5 37.8 1.0
C B:PHE145 3.5 37.8 1.0
C B:PHE254 3.6 37.8 1.0
C A:PHE254 3.6 37.8 1.0
C B:GLY253 4.1 37.8 1.0
CA B:PHE254 4.1 37.8 1.0
C A:GLY253 4.1 37.8 1.0
CA A:PHE254 4.1 37.8 1.0
C A:GLY144 4.1 37.8 1.0
C B:GLY144 4.1 37.8 1.0
CA A:PHE145 4.2 37.8 1.0
CA B:PHE145 4.2 37.8 1.0
N A:GLY146 4.2 33.9 1.0
N B:GLY146 4.2 33.9 1.0
CA A:GLY146 4.4 33.9 1.0
CA B:GLY146 4.4 33.9 1.0
N B:GLY255 4.5 32.3 1.0
N A:GLY255 4.5 32.3 1.0
N B:PHE254 4.6 37.8 1.0
N A:PHE254 4.6 37.8 1.0
N A:PHE145 4.6 37.8 1.0
N B:PHE145 4.6 37.8 1.0
CA B:GLY255 4.8 32.3 1.0
CA A:GLY255 4.8 32.3 1.0

Reference:

P.A.M.Schmidpeter, J.T.Petroff 2Nd, L.Khajoueinejad, A.Wague, C.Frankfater, W.W.L.Cheng, C.M.Nimigean, P.M.Riegelhaupt. Membrane Phospholipids Control Gating of the Mechanosensitive Potassium Leak Channel TREK1. Nat Commun V. 14 1077 2023.
ISSN: ESSN 2041-1723
PubMed: 36841877
DOI: 10.1038/S41467-023-36765-W
Page generated: Wed Apr 5 10:42:51 2023

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