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Potassium in PDB 7zkl: X-Ray Structure of the Complex Between Human Alpha Thrombin and A Pseudo-Cyclic Thrombin Binding Aptamer (Tba-Nnp/Ddp) - Crystal Form Alpha

Enzymatic activity of X-Ray Structure of the Complex Between Human Alpha Thrombin and A Pseudo-Cyclic Thrombin Binding Aptamer (Tba-Nnp/Ddp) - Crystal Form Alpha

All present enzymatic activity of X-Ray Structure of the Complex Between Human Alpha Thrombin and A Pseudo-Cyclic Thrombin Binding Aptamer (Tba-Nnp/Ddp) - Crystal Form Alpha:
3.4.21.5;

Protein crystallography data

The structure of X-Ray Structure of the Complex Between Human Alpha Thrombin and A Pseudo-Cyclic Thrombin Binding Aptamer (Tba-Nnp/Ddp) - Crystal Form Alpha, PDB code: 7zkl was solved by R.Troisi, F.Sica, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 76.57 / 3.18
Space group P 64
Cell size a, b, c (Å), α, β, γ (°) 152.91, 152.91, 79.49, 90, 90, 120
R / Rfree (%) 19.1 / 23.1

Other elements in 7zkl:

The structure of X-Ray Structure of the Complex Between Human Alpha Thrombin and A Pseudo-Cyclic Thrombin Binding Aptamer (Tba-Nnp/Ddp) - Crystal Form Alpha also contains other interesting chemical elements:

Sodium (Na) 1 atom

Potassium Binding Sites:

The binding sites of Potassium atom in the X-Ray Structure of the Complex Between Human Alpha Thrombin and A Pseudo-Cyclic Thrombin Binding Aptamer (Tba-Nnp/Ddp) - Crystal Form Alpha (pdb code 7zkl). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the X-Ray Structure of the Complex Between Human Alpha Thrombin and A Pseudo-Cyclic Thrombin Binding Aptamer (Tba-Nnp/Ddp) - Crystal Form Alpha, PDB code: 7zkl:

Potassium binding site 1 out of 1 in 7zkl

Go back to Potassium Binding Sites List in 7zkl
Potassium binding site 1 out of 1 in the X-Ray Structure of the Complex Between Human Alpha Thrombin and A Pseudo-Cyclic Thrombin Binding Aptamer (Tba-Nnp/Ddp) - Crystal Form Alpha


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of X-Ray Structure of the Complex Between Human Alpha Thrombin and A Pseudo-Cyclic Thrombin Binding Aptamer (Tba-Nnp/Ddp) - Crystal Form Alpha within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K103

b:103.7
occ:1.00
O6 A:DG15 2.6 102.9 1.0
O6 A:DG10 2.7 92.5 1.0
O6 A:DG5 2.7 106.3 1.0
O6 A:DG1 2.8 99.2 1.0
O6 A:DG6 2.9 109.5 1.0
O6 A:DG11 3.0 101.0 1.0
O6 A:DG2 3.2 89.5 1.0
O6 A:DG14 3.2 94.7 1.0
N1 A:DG6 3.4 101.8 1.0
C6 A:DG10 3.5 91.3 1.0
C6 A:DG5 3.5 104.1 1.0
C6 A:DG6 3.6 110.9 1.0
C6 A:DG15 3.6 104.2 1.0
N1 A:DG10 3.7 88.8 1.0
C6 A:DG1 3.8 97.1 1.0
C6 A:DG14 3.8 99.3 1.0
C6 A:DG11 3.9 98.8 1.0
N1 A:DG15 3.9 101.6 1.0
N1 A:DG14 3.9 100.8 1.0
N1 A:DG5 4.0 105.3 1.0
N1 A:DG1 4.1 94.8 1.0
N1 A:DG11 4.1 95.8 1.0
C6 A:DG2 4.2 90.1 1.0
O A:HOH201 4.3 121.6 1.0
C36 A:JL0101 4.5 105.5 1.0
N1 A:DG2 4.5 91.4 1.0
C37 A:JL0101 4.6 104.2 1.0
C5 A:DG5 4.6 104.6 1.0
C2 A:DG6 4.7 105.1 1.0
C5 A:DG10 4.8 91.5 1.0
C35 A:JL0101 4.9 108.1 1.0
C38 A:JL0101 4.9 107.1 1.0
C5 A:DG15 4.9 107.2 1.0
N2 A:DG6 5.0 105.8 1.0
C5 A:DG6 5.0 114.0 1.0

Reference:

R.Troisi, C.Riccardi, K.Perez De Carvasal, M.Smietana, F.Morvan, P.Del Vecchio, D.Montesarchio, F.Sica. A Terminal Functionalization Strategy Reveals Unusual Binding Abilities of Anti-Thrombin Anticoagulant Aptamers. Mol Ther Nucleic Acids V. 30 585 2022.
ISSN: ISSN 2162-2531
PubMed: 36457701
DOI: 10.1016/J.OMTN.2022.11.007
Page generated: Mon Aug 12 21:49:37 2024

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