Potassium in PDB 7xnl: Human KCNQ1-Cam-ML277-PIP2 Complex in State A
Potassium Binding Sites:
The binding sites of Potassium atom in the Human KCNQ1-Cam-ML277-PIP2 Complex in State A
(pdb code 7xnl). This binding sites where shown within
5.0 Angstroms radius around Potassium atom.
In total 4 binding sites of Potassium where determined in the
Human KCNQ1-Cam-ML277-PIP2 Complex in State A, PDB code: 7xnl:
Jump to Potassium binding site number:
1;
2;
3;
4;
Potassium binding site 1 out
of 4 in 7xnl
Go back to
Potassium Binding Sites List in 7xnl
Potassium binding site 1 out
of 4 in the Human KCNQ1-Cam-ML277-PIP2 Complex in State A
 Mono view
 Stereo pair view
|
|
A full contact list of Potassium with other atoms in the K binding
site number 1 of Human KCNQ1-Cam-ML277-PIP2 Complex in State A within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K701
b:43.3
occ:1.00
|
O
|
G:GLY314
|
2.8
|
33.4
|
1.0
|
|
O
|
A:GLY314
|
2.8
|
33.4
|
1.0
|
|
O
|
E:GLY314
|
2.8
|
33.6
|
1.0
|
|
O
|
C:GLY314
|
2.8
|
33.9
|
1.0
|
|
K
|
A:K702
|
3.0
|
38.7
|
1.0
|
|
O
|
E:TYR315
|
3.1
|
35.5
|
1.0
|
|
O
|
C:TYR315
|
3.1
|
35.8
|
1.0
|
|
O
|
G:TYR315
|
3.1
|
35.4
|
1.0
|
|
O
|
A:TYR315
|
3.2
|
35.3
|
1.0
|
|
HA
|
E:TYR315
|
3.5
|
35.5
|
1.0
|
|
HA
|
C:TYR315
|
3.5
|
35.8
|
1.0
|
|
HA
|
G:TYR315
|
3.5
|
35.4
|
1.0
|
|
HA
|
A:TYR315
|
3.6
|
35.3
|
1.0
|
|
C
|
E:TYR315
|
3.6
|
35.5
|
1.0
|
|
C
|
C:TYR315
|
3.6
|
35.8
|
1.0
|
|
C
|
G:TYR315
|
3.6
|
35.4
|
1.0
|
|
C
|
A:TYR315
|
3.6
|
35.3
|
1.0
|
|
C
|
E:GLY314
|
3.9
|
33.6
|
1.0
|
|
C
|
G:GLY314
|
3.9
|
33.4
|
1.0
|
|
C
|
C:GLY314
|
3.9
|
33.9
|
1.0
|
|
C
|
A:GLY314
|
3.9
|
33.4
|
1.0
|
|
CA
|
E:TYR315
|
4.0
|
35.5
|
1.0
|
|
CA
|
C:TYR315
|
4.0
|
35.8
|
1.0
|
|
CA
|
G:TYR315
|
4.0
|
35.4
|
1.0
|
|
CA
|
A:TYR315
|
4.1
|
35.3
|
1.0
|
|
HA3
|
C:GLY316
|
4.2
|
38.6
|
1.0
|
|
HA3
|
A:GLY316
|
4.2
|
38.9
|
1.0
|
|
HA3
|
G:GLY316
|
4.2
|
38.8
|
1.0
|
|
HA3
|
E:GLY316
|
4.2
|
38.4
|
1.0
|
|
N
|
C:GLY316
|
4.4
|
38.6
|
1.0
|
|
N
|
E:GLY316
|
4.4
|
38.4
|
1.0
|
|
N
|
G:GLY316
|
4.4
|
38.8
|
1.0
|
|
N
|
A:GLY316
|
4.4
|
38.9
|
1.0
|
|
N
|
E:TYR315
|
4.5
|
35.5
|
1.0
|
|
N
|
C:TYR315
|
4.5
|
35.8
|
1.0
|
|
N
|
G:TYR315
|
4.5
|
35.4
|
1.0
|
|
N
|
A:TYR315
|
4.5
|
35.3
|
1.0
|
|
CA
|
C:GLY316
|
4.8
|
38.6
|
1.0
|
|
CA
|
A:GLY316
|
4.8
|
38.9
|
1.0
|
|
CA
|
G:GLY316
|
4.8
|
38.8
|
1.0
|
|
CA
|
E:GLY316
|
4.8
|
38.4
|
1.0
|
|
H
|
C:GLY316
|
5.0
|
38.6
|
1.0
|
|
H
|
E:GLY316
|
5.0
|
38.4
|
1.0
|
|
H
|
G:GLY316
|
5.0
|
38.8
|
1.0
|
|
HA3
|
A:GLY314
|
5.0
|
33.4
|
1.0
|
|
H
|
A:GLY316
|
5.0
|
38.9
|
1.0
|
|
HA3
|
G:GLY314
|
5.0
|
33.4
|
1.0
|
|
HA3
|
C:GLY314
|
5.0
|
33.9
|
1.0
|
|
HA3
|
E:GLY314
|
5.0
|
33.6
|
1.0
|
|
Potassium binding site 2 out
of 4 in 7xnl
Go back to
Potassium Binding Sites List in 7xnl
Potassium binding site 2 out
of 4 in the Human KCNQ1-Cam-ML277-PIP2 Complex in State A
 Mono view
 Stereo pair view
|
|
A full contact list of Potassium with other atoms in the K binding
site number 2 of Human KCNQ1-Cam-ML277-PIP2 Complex in State A within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K702
b:38.7
occ:1.00
|
O
|
C:GLY314
|
2.6
|
33.9
|
1.0
|
|
O
|
A:GLY314
|
2.6
|
33.4
|
1.0
|
|
O
|
G:GLY314
|
2.7
|
33.4
|
1.0
|
|
O
|
E:GLY314
|
2.7
|
33.6
|
1.0
|
|
O
|
A:ILE313
|
2.7
|
33.4
|
1.0
|
|
O
|
E:ILE313
|
2.7
|
32.1
|
1.0
|
|
O
|
G:ILE313
|
2.7
|
32.9
|
1.0
|
|
O
|
C:ILE313
|
2.7
|
32.3
|
1.0
|
|
K
|
A:K701
|
3.0
|
43.3
|
1.0
|
|
C
|
C:GLY314
|
3.5
|
33.9
|
1.0
|
|
C
|
A:GLY314
|
3.5
|
33.4
|
1.0
|
|
C
|
E:GLY314
|
3.5
|
33.6
|
1.0
|
|
C
|
G:GLY314
|
3.5
|
33.4
|
1.0
|
|
HA3
|
A:GLY314
|
3.6
|
33.4
|
1.0
|
|
HA3
|
G:GLY314
|
3.6
|
33.4
|
1.0
|
|
HA3
|
C:GLY314
|
3.6
|
33.9
|
1.0
|
|
HA3
|
E:GLY314
|
3.6
|
33.6
|
1.0
|
|
K
|
A:K703
|
3.6
|
80.4
|
1.0
|
|
C
|
A:ILE313
|
3.8
|
33.4
|
1.0
|
|
C
|
G:ILE313
|
3.8
|
32.9
|
1.0
|
|
C
|
E:ILE313
|
3.8
|
32.1
|
1.0
|
|
C
|
C:ILE313
|
3.8
|
32.3
|
1.0
|
|
CA
|
A:GLY314
|
4.0
|
33.4
|
1.0
|
|
CA
|
G:GLY314
|
4.0
|
33.4
|
1.0
|
|
CA
|
C:GLY314
|
4.0
|
33.9
|
1.0
|
|
CA
|
E:GLY314
|
4.0
|
33.6
|
1.0
|
|
N
|
A:GLY314
|
4.4
|
33.4
|
1.0
|
|
N
|
G:GLY314
|
4.4
|
33.4
|
1.0
|
|
N
|
E:GLY314
|
4.4
|
33.6
|
1.0
|
|
N
|
C:GLY314
|
4.4
|
33.9
|
1.0
|
|
HA
|
E:TYR315
|
4.4
|
35.5
|
1.0
|
|
HA
|
C:TYR315
|
4.4
|
35.8
|
1.0
|
|
HA
|
G:TYR315
|
4.4
|
35.4
|
1.0
|
|
HA
|
A:TYR315
|
4.4
|
35.3
|
1.0
|
|
N
|
E:TYR315
|
4.5
|
35.5
|
1.0
|
|
N
|
C:TYR315
|
4.5
|
35.8
|
1.0
|
|
N
|
G:TYR315
|
4.5
|
35.4
|
1.0
|
|
N
|
A:TYR315
|
4.5
|
35.3
|
1.0
|
|
HA2
|
A:GLY314
|
4.9
|
33.4
|
1.0
|
|
HA2
|
G:GLY314
|
4.9
|
33.4
|
1.0
|
|
HA2
|
C:GLY314
|
4.9
|
33.9
|
1.0
|
|
HA2
|
E:GLY314
|
4.9
|
33.6
|
1.0
|
|
CA
|
C:TYR315
|
4.9
|
35.8
|
1.0
|
|
CA
|
E:TYR315
|
4.9
|
35.5
|
1.0
|
|
HA
|
E:ILE313
|
4.9
|
32.1
|
1.0
|
|
HA
|
C:ILE313
|
4.9
|
32.3
|
1.0
|
|
HA
|
A:ILE313
|
4.9
|
33.4
|
1.0
|
|
HA
|
G:ILE313
|
4.9
|
32.9
|
1.0
|
|
CA
|
G:TYR315
|
4.9
|
35.4
|
1.0
|
|
CA
|
A:TYR315
|
4.9
|
35.3
|
1.0
|
|
Potassium binding site 3 out
of 4 in 7xnl
Go back to
Potassium Binding Sites List in 7xnl
Potassium binding site 3 out
of 4 in the Human KCNQ1-Cam-ML277-PIP2 Complex in State A
 Mono view
 Stereo pair view
|
|
A full contact list of Potassium with other atoms in the K binding
site number 3 of Human KCNQ1-Cam-ML277-PIP2 Complex in State A within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K703
b:80.4
occ:1.00
|
O
|
A:THR312
|
2.7
|
35.5
|
1.0
|
|
O
|
G:THR312
|
2.7
|
35.3
|
1.0
|
|
O
|
E:THR312
|
2.7
|
35.5
|
1.0
|
|
O
|
C:THR312
|
2.8
|
36.1
|
1.0
|
|
O
|
E:ILE313
|
2.8
|
32.1
|
1.0
|
|
O
|
C:ILE313
|
2.8
|
32.3
|
1.0
|
|
O
|
G:ILE313
|
2.9
|
32.9
|
1.0
|
|
O
|
A:ILE313
|
2.9
|
33.4
|
1.0
|
|
HA
|
E:ILE313
|
3.3
|
32.1
|
1.0
|
|
HA
|
C:ILE313
|
3.3
|
32.3
|
1.0
|
|
HA
|
G:ILE313
|
3.3
|
32.9
|
1.0
|
|
HA
|
A:ILE313
|
3.3
|
33.4
|
1.0
|
|
K
|
A:K704
|
3.4
|
43.6
|
1.0
|
|
C
|
E:ILE313
|
3.6
|
32.1
|
1.0
|
|
C
|
C:ILE313
|
3.6
|
32.3
|
1.0
|
|
C
|
G:ILE313
|
3.6
|
32.9
|
1.0
|
|
C
|
A:ILE313
|
3.6
|
33.4
|
1.0
|
|
K
|
A:K702
|
3.6
|
38.7
|
1.0
|
|
C
|
A:THR312
|
3.7
|
35.5
|
1.0
|
|
C
|
E:THR312
|
3.7
|
35.5
|
1.0
|
|
C
|
G:THR312
|
3.7
|
35.3
|
1.0
|
|
C
|
C:THR312
|
3.7
|
36.1
|
1.0
|
|
CA
|
E:ILE313
|
3.8
|
32.1
|
1.0
|
|
CA
|
C:ILE313
|
3.8
|
32.3
|
1.0
|
|
CA
|
G:ILE313
|
3.8
|
32.9
|
1.0
|
|
CA
|
A:ILE313
|
3.8
|
33.4
|
1.0
|
|
N
|
E:ILE313
|
4.2
|
32.1
|
1.0
|
|
N
|
A:ILE313
|
4.2
|
33.4
|
1.0
|
|
N
|
G:ILE313
|
4.2
|
32.9
|
1.0
|
|
N
|
C:ILE313
|
4.2
|
32.3
|
1.0
|
|
HB
|
A:THR312
|
4.4
|
35.5
|
1.0
|
|
HB
|
G:THR312
|
4.4
|
35.3
|
1.0
|
|
HB
|
E:THR312
|
4.5
|
35.5
|
1.0
|
|
HB
|
C:THR312
|
4.5
|
36.1
|
1.0
|
|
N
|
E:GLY314
|
4.7
|
33.6
|
1.0
|
|
N
|
C:GLY314
|
4.7
|
33.9
|
1.0
|
|
N
|
G:GLY314
|
4.7
|
33.4
|
1.0
|
|
N
|
A:GLY314
|
4.7
|
33.4
|
1.0
|
|
HA3
|
A:GLY314
|
4.8
|
33.4
|
1.0
|
|
HA3
|
E:GLY314
|
4.8
|
33.6
|
1.0
|
|
HA3
|
G:GLY314
|
4.8
|
33.4
|
1.0
|
|
HA3
|
C:GLY314
|
4.8
|
33.9
|
1.0
|
|
CA
|
A:THR312
|
4.8
|
35.5
|
1.0
|
|
CA
|
G:THR312
|
4.9
|
35.3
|
1.0
|
|
CA
|
E:THR312
|
4.9
|
35.5
|
1.0
|
|
CA
|
C:THR312
|
4.9
|
36.1
|
1.0
|
|
HA
|
A:THR312
|
4.9
|
35.5
|
1.0
|
|
HA
|
G:THR312
|
4.9
|
35.3
|
1.0
|
|
HA
|
E:THR312
|
4.9
|
35.5
|
1.0
|
|
HA
|
C:THR312
|
4.9
|
36.1
|
1.0
|
|
H
|
E:ILE313
|
5.0
|
32.1
|
1.0
|
|
Potassium binding site 4 out
of 4 in 7xnl
Go back to
Potassium Binding Sites List in 7xnl
Potassium binding site 4 out
of 4 in the Human KCNQ1-Cam-ML277-PIP2 Complex in State A
 Mono view
 Stereo pair view
|
|
A full contact list of Potassium with other atoms in the K binding
site number 4 of Human KCNQ1-Cam-ML277-PIP2 Complex in State A within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K704
b:43.6
occ:1.00
|
O
|
E:THR312
|
2.8
|
35.5
|
1.0
|
|
HB
|
A:THR312
|
2.8
|
35.5
|
1.0
|
|
HB
|
G:THR312
|
2.8
|
35.3
|
1.0
|
|
O
|
A:THR312
|
2.8
|
35.5
|
1.0
|
|
O
|
G:THR312
|
2.8
|
35.3
|
1.0
|
|
O
|
C:THR312
|
2.8
|
36.1
|
1.0
|
|
HB
|
E:THR312
|
2.8
|
35.5
|
1.0
|
|
HB
|
C:THR312
|
2.8
|
36.1
|
1.0
|
|
OG1
|
A:THR312
|
3.4
|
35.5
|
1.0
|
|
OG1
|
G:THR312
|
3.4
|
35.3
|
1.0
|
|
OG1
|
E:THR312
|
3.4
|
35.5
|
1.0
|
|
K
|
A:K703
|
3.4
|
80.4
|
1.0
|
|
OG1
|
C:THR312
|
3.4
|
36.1
|
1.0
|
|
CB
|
A:THR312
|
3.5
|
35.5
|
1.0
|
|
CB
|
G:THR312
|
3.5
|
35.3
|
1.0
|
|
CB
|
E:THR312
|
3.5
|
35.5
|
1.0
|
|
CB
|
C:THR312
|
3.5
|
36.1
|
1.0
|
|
HG1
|
A:THR312
|
3.6
|
35.5
|
1.0
|
|
HG1
|
G:THR312
|
3.6
|
35.3
|
1.0
|
|
HG1
|
E:THR312
|
3.6
|
35.5
|
1.0
|
|
HG1
|
C:THR312
|
3.6
|
36.1
|
1.0
|
|
C
|
E:THR312
|
3.8
|
35.5
|
1.0
|
|
C
|
A:THR312
|
3.8
|
35.5
|
1.0
|
|
C
|
G:THR312
|
3.8
|
35.3
|
1.0
|
|
C
|
C:THR312
|
3.8
|
36.1
|
1.0
|
|
CA
|
A:THR312
|
4.3
|
35.5
|
1.0
|
|
CA
|
G:THR312
|
4.3
|
35.3
|
1.0
|
|
CA
|
E:THR312
|
4.3
|
35.5
|
1.0
|
|
CA
|
C:THR312
|
4.3
|
36.1
|
1.0
|
|
HG21
|
A:THR312
|
4.4
|
35.5
|
1.0
|
|
HG21
|
G:THR312
|
4.4
|
35.3
|
1.0
|
|
HG21
|
E:THR312
|
4.5
|
35.5
|
1.0
|
|
HG21
|
C:THR312
|
4.5
|
36.1
|
1.0
|
|
CG2
|
A:THR312
|
4.6
|
35.5
|
1.0
|
|
CG2
|
G:THR312
|
4.6
|
35.3
|
1.0
|
|
CG2
|
E:THR312
|
4.6
|
35.5
|
1.0
|
|
CG2
|
C:THR312
|
4.6
|
36.1
|
1.0
|
|
HA
|
A:THR312
|
4.7
|
35.5
|
1.0
|
|
HA
|
G:THR312
|
4.7
|
35.3
|
1.0
|
|
HA
|
E:THR312
|
4.7
|
35.5
|
1.0
|
|
HA
|
C:THR312
|
4.7
|
36.1
|
1.0
|
|
HA
|
C:ILE313
|
4.7
|
32.3
|
1.0
|
|
HA
|
E:ILE313
|
4.7
|
32.1
|
1.0
|
|
HA
|
A:ILE313
|
4.7
|
33.4
|
1.0
|
|
HA
|
G:ILE313
|
4.7
|
32.9
|
1.0
|
|
N
|
E:ILE313
|
5.0
|
32.1
|
1.0
|
|
N
|
A:ILE313
|
5.0
|
33.4
|
1.0
|
|
N
|
G:ILE313
|
5.0
|
32.9
|
1.0
|
|
N
|
C:ILE313
|
5.0
|
32.3
|
1.0
|
|
HG22
|
A:THR312
|
5.0
|
35.5
|
1.0
|
|
HG22
|
G:THR312
|
5.0
|
35.3
|
1.0
|
|
Reference:
D.Ma,
L.Zhong,
Z.Yan,
J.Yao,
Y.Zhang,
F.Ye,
Y.Huang,
D.Lai,
W.Yang,
P.Hou,
J.Guo.
Structural Mechanisms For the Activation of Human Cardiac KCNQ1 Channel By Electro-Mechanical Coupling Enhancers Proc.Natl.Acad.Sci.Usa V. 119 2022.
ISSN: ESSN 1091-6490
DOI: 10.1073/PNAS.2207067119
Page generated: Mon Aug 12 21:35:44 2024
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