Potassium in PDB 7x21: Cryo-Em Structure of Non Gastric H,K-Atpase ALPHA2 K794A in (K+)E2-Alf State

All present enzymatic activity of Cryo-Em Structure of Non Gastric H,K-Atpase ALPHA2 K794A in (K+)E2-Alf State:
7.2.2.13; 7.2.2.19;

The structure of Cryo-Em Structure of Non Gastric H,K-Atpase ALPHA2 K794A in (K+)E2-Alf State also contains other interesting chemical elements:

Fluorine	(F)	4 atoms
Magnesium	(Mg)	1 atom
Aluminium	(Al)	1 atom

The binding sites of Potassium atom in the Cryo-Em Structure of Non Gastric H,K-Atpase ALPHA2 K794A in (K+)E2-Alf State (pdb code 7x21). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Cryo-Em Structure of Non Gastric H,K-Atpase ALPHA2 K794A in (K+)E2-Alf State, PDB code: 7x21:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the Cryo-Em Structure of Non Gastric H,K-Atpase ALPHA2 K794A in (K+)E2-Alf State


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Cryo-Em Structure of Non Gastric H,K-Atpase ALPHA2 K794A in (K+)E2-Alf State within 5.0Å range: probe atom residue distance (Å) B Occ A:K1101 b:19.3 occ:1.00 OD2 A:ASP823 2.7 31.0 1.0 O A:VAL344 2.7 21.5 1.0 O A:ALA342 2.8 20.4 1.0 OD1 A:ASN795 2.9 17.5 1.0 O A:HOH1201 3.0 32.0 1.0 O A:VAL341 3.0 25.1 1.0 OD1 A:ASP823 3.2 31.0 1.0 CG A:ASP823 3.3 31.0 1.0 OE2 A:GLU798 3.3 17.0 1.0 OE1 A:GLU346 3.4 26.2 1.0 C A:ALA342 3.5 20.4 1.0 O A:HOH1202 3.6 28.4 1.0 C A:VAL344 3.7 21.5 1.0 CG A:ASN795 3.8 17.5 1.0 CA A:ALA342 3.8 20.4 1.0 CD A:GLU798 4.0 17.0 1.0 OE1 A:GLU798 4.1 17.0 1.0 C A:VAL341 4.1 25.1 1.0 N A:VAL344 4.2 21.5 1.0 CD A:GLU346 4.3 26.2 1.0 N A:PRO345 4.4 23.3 1.0 CA A:PRO345 4.4 23.3 1.0 N A:ALA342 4.5 20.4 1.0 ND2 A:ASN795 4.5 17.5 1.0 OE2 A:GLU346 4.5 26.2 1.0 N A:ASN343 4.5 24.3 1.0 CA A:ASN795 4.5 17.5 1.0 CB A:ASN795 4.6 17.5 1.0 CA A:VAL344 4.6 21.5 1.0 C A:ASN343 4.7 24.3 1.0 CB A:ASP823 4.7 31.0 1.0 N A:GLU346 4.9 26.2 1.0

Potassium binding site 2 out of 2 in the Cryo-Em Structure of Non Gastric H,K-Atpase ALPHA2 K794A in (K+)E2-Alf State


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Cryo-Em Structure of Non Gastric H,K-Atpase ALPHA2 K794A in (K+)E2-Alf State within 5.0Å range: probe atom residue distance (Å) B Occ A:K1102 b:30.4 occ:1.00 O A:ALA740 2.8 21.4 1.0 O A:HOH1205 2.9 27.6 1.0 OD2 A:ASP759 2.9 21.4 1.0 O A:LEU737 2.9 18.9 1.0 O A:LYS738 3.4 28.1 1.0 CG A:ASP759 3.6 21.4 1.0 C A:LYS738 3.7 28.1 1.0 OD1 A:ASP759 3.8 21.4 1.0 CA A:LYS738 3.8 28.1 1.0 C A:ALA740 3.9 21.4 1.0 C A:LEU737 4.0 18.9 1.0 N A:GLY743 4.1 15.9 1.0 O A:ASP741 4.2 21.8 1.0 N A:ALA740 4.3 21.4 1.0 C A:ASP741 4.4 21.8 1.0 N A:LYS738 4.4 28.1 1.0 C A:ILE742 4.5 15.2 1.0 CA A:ILE742 4.5 15.2 1.0 CA A:ALA740 4.6 21.4 1.0 O A:ALA757 4.6 24.2 1.0 N A:ILE742 4.6 15.2 1.0 N A:LYS739 4.7 26.5 1.0 CA A:GLY743 4.7 15.9 1.0 C A:LYS739 4.7 26.5 1.0 O A:HOH1204 4.8 27.9 1.0 CD A:LYS738 4.9 28.1 1.0 N A:ASP741 4.9 21.8 1.0 CB A:ALA740 4.9 21.4 1.0 CB A:ASP759 4.9 21.4 1.0

V.C.Young, H.Nakanishi, D.J.Meyer, T.Nishizawa, A.Oshima, P.Artigas, K.Abe. Structure and Function of H + /K + Pump Mutants Reveal Na + /K + Pump Mechanisms. Nat Commun V. 13 5270 2022.
ISSN: ESSN 2041-1723
PubMed: 36085139
DOI: 10.1038/S41467-022-32793-0